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Transfer Learning enables Convolutional Neural Networks (CNN) to acquire knowledge from a source domain and transfer it to a target domain, where collecting large-scale annotated examples is time-consuming and expensive. Conventionally,…

计算机视觉与模式识别 · 计算机科学 2024-01-25 S. H. Shabbeer Basha , Debapriya Tula , Sravan Kumar Vinakota , Shiv Ram Dubey

T cell receptor (TCR) recognition of peptide-MHC (pMHC) complexes is a central component of adaptive immunity, with implications for vaccine design, cancer immunotherapy, and autoimmune disease. While recent advances in machine learning…

定量方法 · 定量生物学 2026-03-09 Jiarui Li , Zixiang Yin , Zhengming Ding , Samuel J. Landry , Ramgopal R. Mettu

Domain adaptive semantic segmentation aims to transfer knowledge from a labeled source domain to an unlabeled target domain. However, existing methods primarily focus on directly learning qualified target features, making it challenging to…

计算机视觉与模式识别 · 计算机科学 2024-10-24 Haochen Wang , Yujun Shen , Jingjing Fei , Wei Li , Liwei Wu , Yuxi Wang , Zhaoxiang Zhang

The scarcity of labelled data is specifically an urgent challenge in the field of quantum machine learning (QML). Two transfer fusion frameworks are proposed in this paper to predict the labels of a target domain data by aligning its…

计算机视觉与模式识别 · 计算机科学 2024-11-05 Xi He , Feiyu Du , Xiaohan Yu , Yang Zhao , Tao Lei

The recent success of deep neural networks relies on massive amounts of labeled data. For a target task where labeled data is unavailable, domain adaptation can transfer a learner from a different source domain. In this paper, we propose a…

机器学习 · 计算机科学 2017-02-17 Mingsheng Long , Han Zhu , Jianmin Wang , Michael I. Jordan

Semantic segmentation relies on many dense pixel-wise annotations to achieve the best performance, but owing to the difficulty of obtaining accurate annotations for real world data, practitioners train on large-scale synthetic datasets.…

计算机视觉与模式识别 · 计算机科学 2025-07-14 Cristina Mata , Michael S. Ryoo , Henrik Turbell

Non-coding RNA are functional molecules that are not translated into proteins. Their function comes as important regulators of biological function. Because they are not translated, they need not be as stable as other types of RNA. The TKF91…

其他定量生物学 · 定量生物学 2024-05-27 Brandon Legried

Automated semantic segmentation of cell nuclei in microscopic images is crucial for disease diagnosis and tissue microenvironment analysis. Nonetheless, this task presents challenges due to the complexity and heterogeneity of cells. While…

图像与视频处理 · 电气工程与系统科学 2023-08-10 Zhuchen Shao , Sourya Sengupta , Hua Li , Mark A. Anastasio

Background: High-throughput techniques bring novel tools but also statistical challenges to genomic research. Identifying genes with differential expression between different species is an effective way to discover evolutionarily conserved…

统计方法学 · 统计学 2018-10-05 Yan Zhou , Jiadi Zhu , Tiejun Tong , Junhui Wang , Bingqing Lin , Jun Zhang

Understanding gene regulation is a fundamental step towards understanding of how cells function and respond to environmental cues and perturbations. An important step in this direction is to infer the transcription factor-gene regulatory…

分子网络 · 定量生物学 2017-04-25 Yijie Wang , Dong-Yeon Cho , Hangnoh Lee , Justin Fear , Brian Oliver , Teresa M Przytycka

Understanding the binding specificity between T-cell receptors (TCRs) and peptide-major histocompatibility complexes (pMHCs) is central to immunotherapy and vaccine development. However, current predictive models struggle with…

定量方法 · 定量生物学 2025-12-29 Cong Qi , Hanzhang Fang , Siqi jiang , Tianxing Hu , Zhi Wei

This paper considers the estimation and prediction of a high-dimensional linear regression in the setting of transfer learning, using samples from the target model as well as auxiliary samples from different but possibly related regression…

统计方法学 · 统计学 2020-06-19 Sai Li , T. Tony Cai , Hongzhe Li

We consider the Hypothesis Transfer Learning (HTL) problem where one incorporates a hypothesis trained on the source domain into the learning procedure of the target domain. Existing theoretical analysis either only studies specific…

机器学习 · 统计学 2017-11-07 Simon Shaolei Du , Jayanth Koushik , Aarti Singh , Barnabas Poczos

Oracle bone script is the earliest-known Chinese writing system of the Shang dynasty and is precious to archeology and philology. However, real-world scanned oracle data are rare and few experts are available for annotation which make the…

计算机视觉与模式识别 · 计算机科学 2022-05-16 Mei Wang , Weihong Deng , Cheng-Lin Liu

The emerging field semantic communication is driving the research of end-to-end data transmission. By utilizing the powerful representation ability of deep learning models, learned data transmission schemes have exhibited superior…

信息论 · 计算机科学 2023-05-25 Jincheng Dai , Sixian Wang , Ke Yang , Kailin Tan , Xiaoqi Qin , Zhongwei Si , Kai Niu , Ping Zhang

To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6-10^9 decoy sites? Our analysis of 319 known TF binding motifs clearly…

基因组学 · 定量生物学 2009-01-21 Leonid A. Mirny , Zeba Wunderlich

This paper focuses on the problem of semi-supervised domain adaptation for time-series forecasting, which is underexplored in literatures, despite being often encountered in practice. Existing methods on time-series domain adaptation mainly…

机器学习 · 计算机科学 2023-09-07 Zijian Li , Ruichu Cai , Tom Z. J Fu , Zhifeng Hao , Kun Zhang

Modern language models define distributions over strings, but downstream tasks often require different output formats. For instance, a model that generates byte-pair strings does not directly produce word-level predictions, and a DNA model…

计算与语言 · 计算机科学 2026-03-09 Vésteinn Snæbjarnarson , Samuel Kiegeland , Tianyu Liu , Reda Boumasmoud , Ryan Cotterell , Tim Vieira

We explore semantic segmentation beyond the conventional, single-dataset homogeneous training and bring forward the problem of Heterogeneous Training of Semantic Segmentation (HTSS). HTSS involves simultaneous training on multiple…

计算机视觉与模式识别 · 计算机科学 2023-01-19 Panagiotis Meletis , Gijs Dubbelman

The Neural Tangent Kernel (NTK) characterizes how a model's state evolves over Gradient Descent. Computing the full NTK matrix is often infeasible, especially for recurrent architectures. Here, we introduce a matrix-free perspective, using…

机器学习 · 计算机科学 2025-11-17 James Hazelden