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Decoding the heterogeneity of biological neural systems is key to understanding the nervous system's complex dynamical behaviors. This study analyzes the comprehensive Drosophila brain connectome, which is the most recent data set,…

神经元与认知 · 定量生物学 2025-10-01 Xiaoyu Zhang , Pengcheng Yang , Yifei Zhang , Bowei Qin , Qiang Luo , Wei Lin , Xin Lu

How intelligence emerges from living beings has been a fundamental question in neuroscience. However, it remains largely unanswered due to the complex neuronal dynamics and intricate connections between neurons in real neural systems. To…

神经元与认知 · 定量生物学 2024-09-04 Xiaoyu Zhang , Pengcheng Yang , Jiawei Feng , Qiang Luo , Wei Lin , Xin Lu

Naturally occurring networks exhibit quantitative features revealing underlying growth mechanisms. Numerous network mechanisms have recently been proposed to reproduce specific properties such as degree distributions or clustering…

定量方法 · 定量生物学 2009-11-10 Manuel Middendorf , Etay Ziv , Chris Wiggins

The recent reconstruction of the Drosophila brain provides a neural network of unprecedented size and level of details. In this work, we study the geometrical properties of this system by applying network embedding techniques to the graph…

物理与社会 · 物理学 2026-02-19 Bendegúz Sulyok , Sámuel G. Balogh , Gergely Palla

This report investigates the modular organisation of the Central region in the Drosophila connectome. We identify groups of neurones amongst which information circulates rapidly before spreading to the rest of the network using Infomap. We…

神经元与认知 · 定量生物学 2024-12-19 Peter Grindrod , Renaud Lambiotte , Rohit Sahasrabuddhe

We demonstrate the first-ever nontrivial, biologically realistic connectome simulated on neuromorphic computing hardware. Specifically, we implement the whole-brain connectome of the adult Drosophila melanogaster (fruit fly) from the…

分布式、并行与集群计算 · 计算机科学 2025-08-26 Felix Wang , Bradley H. Theilman , Fred Rothganger , William Severa , Craig M. Vineyard , James B. Aimone

The brain is immensely complex, with diverse components and dynamic interactions building upon one another to orchestrate a wide range of functions and behaviors. Understanding patterns of these complex interactions and how they are…

神经元与认知 · 定量生物学 2024-08-06 Suman Kulkarni , Dani S. Bassett

The brain is a complex organ characterized by heterogeneous patterns of structural connections supporting unparalleled feats of cognition and a wide range of behaviors. New noninvasive imaging techniques now allow these patterns to be…

神经元与认知 · 定量生物学 2020-04-03 Christopher W. Lynn , Danielle S. Bassett

Modular structure is ubiquitous among real-world networks from related proteins to social groups. Here we analyze the modular organization of brain networks at a large-scale (voxel level) extracted from functional magnetic resonance imaging…

数据分析、统计与概率 · 物理学 2009-04-16 M. Valencia , M. A. Pastor , MA. Fernandez-Seara , J. Artieda , J. Martinerie , M. Chavez

Neurons, with their elongated, tree-like dendritic and axonal structures, enable efficient signal integration and long-range communication across brain regions. By reconstructing individual neurons' morphology, we can gain valuable insights…

计算机视觉与模式识别 · 计算机科学 2024-11-08 Rubin Zhao , Yang Liu , Shiqi Zhang , Zijian Yi , Yanyang Xiao , Fang Xu , Yi Yang , Pencheng Zhou

Neural circuit reconstruction at single synapse resolution is increasingly recognized as crucially important to decipher the function of biological nervous systems. Volume electron microscopy in serial transmission or scanning mode has been…

计算机视觉与模式识别 · 计算机科学 2018-05-09 Larissa Heinrich , Jan Funke , Constantin Pape , Juan Nunez-Iglesias , Stephan Saalfeld

Even the simplest of animals exhibit behavioral sequences with complex temporal dynamics. Prominent amongst the proposed organizing principles for these dynamics has been the idea of a hierarchy, wherein the movements an animal makes can be…

生物物理 · 物理学 2017-02-08 Gordon J. Berman , William Bialek , Joshua W. Shaevitz

The human brains are organized into hierarchically modular networks facilitating efficient and stable information processing and supporting diverse cognitive processes during the course of development. While the remarkable reconfiguration…

神经元与认知 · 定量生物学 2020-09-16 Xuyun Wen , Liming Hsu , Weili Lin , Han Zhang , Dinggang Shen

We present schema redescription as a methodology to characterize canalization in automata networks used to model biochemical regulation and signalling. In our formulation, canalization becomes synonymous with redundancy present in the logic…

分子网络 · 定量生物学 2013-02-04 Manuel Marques-Pita , Luis M. Rocha

During organogenesis, developmental programs governed by Gene Regulatory Networks (GRN) define the functionality, size and shape of the different constituents of living organisms. Robustness, thus, is an essential characteristic that GRNs…

组织与器官 · 定量生物学 2015-01-07 Daniel Aguilar-Hidalgo , M. Carmen Lemos , Antonio Córdoba

Mapping the connectivity of neurons in the brain (i.e., connectomics) is a challenging problem due to both the number of connections in even the smallest organisms and the nanometer resolution required to resolve them. Because of this,…

神经元与认知 · 定量生物学 2014-09-08 Ting Zhao , Stephen M Plaza

We introduce and analyze a class of neural network models motivated by the Drosophila central complex nervous system, designed to capture the emergence and dynamics of orientation-selective activity bumps. Starting from a biologically…

动力系统 · 数学 2026-04-22 S. Ismail , B. Ambrosio , M. A. Aziz-Alaoui , Y. Souleiman

The brain's intricate connectome, a blueprint for its function, presents immense complexity, yet it arises from a compact genetic code, hinting at underlying low-dimensional organizational principles. This work bridges connectomics and…

人工智能 · 计算机科学 2025-05-28 Yubin Li , Xingyu Liu , Guozhang Chen

We apply an information theoretic treatment of action potential time series measured with microelectrode arrays to estimate the connectivity of mammalian neuronal cell assemblies grown {\it in vitro}. We infer connectivity between two…

神经元与认知 · 定量生物学 2007-05-23 Luis M. A. Bettencourt , Greg J. Stephens , Michael I. Ham , Guenter W. Gross

Today the human brain can be modeled as a graph where nodes represent different regions and links stand for statistical interactions between their activities as recorded by different neuroimaging techniques. Empirical studies have lead to…

神经元与认知 · 定量生物学 2017-11-01 J. H. Martínez , J. M. Buldú , D. Papo , F. De Vico Fallani , M. Chavez
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