相关论文: Invariant death
We have previously reported that a 'universal' growth law with fixed scaling exponent p, as proposed by West and collaborators for all living organisms, appears to be able to describe also the growth of tumors in vivo. Here, we investigate…
Well protected human and laboratory animal populations with abundant resources are evolutionary unprecedented, and their survival far beyond reproductive age may be a byproduct rather than tool of evolution. Physical approach, which takes…
Comparing both, the more conventional Gompertz tumor growth law (GL) and the ``Universal'' law (UL), recently proposed and applied to cancer,we have investigated the growth law's implications on various radiotherapy regimen. According to…
The inheritance of characteristics induced by the environment has often been opposed to the theory of evolution by natural selection. Yet, while evolution by natural selection requires new heritable traits to be produced and transmitted, it…
We consider various mechanisms of modifying the effect of intrinsic curvature in gravity with respect to general relativity. Two primary approaches are studied. First, by considering a Lagrange multiplier or an auxiliary field. Second, by…
Tumor recurrence, driven by the evolution of drug resistance is a major barrier to therapeutic success in cancer. Resistance is often caused by genetic alterations such as point mutation, which refers to the modification of a single genomic…
Understanding the cross-species behavior of cancer is important for uncovering fundamental mechanisms of carcinogenesis, and for translating results of model systems between species. One of the most famous interspecific considerations of…
Community assembly is studied using individual-based multispecies models. The models have stochastic population dynamics with mutation, migration, and extinction of species. Mutants appear as a result of mutation of the resident species,…
Trying to combine standard quantum field theories with gravity leads to a breakdown of the usual structure of space-time at around the Planck length, 1.6*10^{-35} m, with possible violations of Lorentz invariance. Calculations of…
We couple the issue of evolution in the laws of physics with that of violations of energy conservation. We define evolution in terms of time variables canonically dual to ``constants'' (such as $\Lambda$, the Planck mass or the…
An explicit solution for a general two-type birth-death branching process with one way mutation is presented. This continuous time process mimics the evolution of resistance to treatment, or the onset of an extra driver mutation during…
Development of resistance limits efficiency of present anticancer therapies and preventing it remains big challenge in cancer research. It is accepted, at intuitive level, that the resistance emerges as a consequence of cancer cells…
Scale invariance in the theory of classical mechanics can be induced from the scale invariance of background fields. In this paper we consider the relation between the scale invariance and the constants of particle motion in a self-similar…
We investigate the behaviour of quantum fields coupled to a spacetime geometry exhibiting finite regions of Euclidean (Riemannian) signature. Although from a gravity perspective this situation might seem somewhat far fetched, we will…
Cancer results from genetic alterations that disturb the normal cooperative behavior of cells. Recent high-throughput genomic studies of cancer cells have shown that the mutational landscape of cancer is complex and that individual cancers…
Starting from a generic generally covariant classical theory we introduce the logarithmic correction to the quantum wave equation. We demonstrate the emergence of the evolution time from the group of automorphisms of the von Neumann algebra…
Standard treatments of general relativity accept the gravitational slowing of clocks as a primary phenomenon, requiring no further analysis as to cause. Rejecting this attitude, I argue that one or more of the fundamental "constants"…
We develop a geometric formulation of stochastic dynamics in which noise, diffusion, path probabilities, fluctuation theorems, and entropy production arise from the intrinsic geometry of an evolving manifold rather than from externally…
Combinatorial quantum gravity is governed by a discrete Einstein-Hilbert action formulated on an ensemble of random graphs. There is strong evidence for a second-order quantum phase transition separating a random phase at strong coupling…
Most cancers in humans are large, measuring centimeters in diameter, composed of many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as a result of the mutations that occur during each cell division.…