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The cause of failure in cohort studies that involve competing risks is frequently incompletely observed. To address this, several methods have been proposed for the semiparametric proportional cause-specific hazards model under a missing at…

统计方法学 · 统计学 2020-02-24 Giorgos Bakoyannis , Ying Zhang , Constantin T. Yiannoutsos

We consider the situation of estimating Cox regression in which some covariates are subject to missing, and there exists additional information (including observed event time, censoring indicator and fully observed covariates) which may be…

统计方法学 · 统计学 2017-10-16 Chiu-Hsieh Hsu , Mandi Yu

We consider the problem of estimating the distribution of time-to-event data that are subject to censoring and for which the event of interest might never occur, i.e., some subjects are cured. To model this kind of data in the presence of…

统计理论 · 数学 2018-06-05 François Portier , Ingrid Van Keilegom , Anouar El Ghouch

Time-to-event endpoints are frequently used as outcomes in oncology and other disease areas where the outcome of interest may not be observed within a predetermined period. Although many analytical methods address the challenges of…

统计方法学 · 统计学 2026-04-14 Chen-Yen Lin , Susan Halabi , Taehwa Choi

The Fine-Gray model for the subdistribution hazard is commonly used for estimating associations between covariates and competing risks outcomes. When there are missing values in the covariates included in a given model, researchers may wish…

Clustered competing risks data are commonly encountered in multicenter studies. The analysis of such data is often complicated due to informative cluster size, a situation where the outcomes under study are associated with the size of the…

统计方法学 · 统计学 2021-04-26 Wenxian Zhou , Giorgos Bakoyannis , Ying Zhang , Constantin T. Yiannoutsos

Survival analysis aims to explore the relationship between covariates and the time until the occurrence of an event. The Cox proportional hazards model is commonly used for right-censored data, but it is not strictly limited to this type of…

统计方法学 · 统计学 2025-07-02 Abdoulaye Dioni , Lynne Moore , Aida Eslami

Cardiovascular outcome trials commonly face competing risks when non-CV death prevents observation of major adverse cardiovascular events (MACE). While Cox proportional hazards models treat competing events as independent censoring,…

统计方法学 · 统计学 2026-02-19 Tuo Wang , Yu Du

Regression analysis with missing data is a long-standing and challenging problem, particularly when there are many missing variables with arbitrary missing patterns. Likelihood-based methods, although theoretically appealing, are often…

统计方法学 · 统计学 2024-10-16 Ngok Sang Kwok , Kin Yau Wong

The use of massive survival data has become common in survival analysis. In this study, a subsampling algorithm is proposed for the Cox proportional hazards model with time-dependent covariates when the sample is extraordinarily large but…

统计计算 · 统计学 2023-02-07 Nan Qiao , Wangcheng Li , Feng Xiao , Cunjie Lin , Yong Zhou

A class of estimating functions is introduced for the regression parameter of the Cox proportional hazards model to allow unknown failure statuses on some study subjects. The consistency and asymptotic normality of the resulting estimators…

统计理论 · 数学 2007-08-22 Irene Gijbels , Danyu Lin , Zhiliang Ying

Massive sized survival datasets are becoming increasingly prevalent with the development of the healthcare industry. Such datasets pose computational challenges unprecedented in traditional survival analysis use-cases. A popular way for…

统计方法学 · 统计学 2023-05-09 Nir Keret , Malka Gorfine

We study problems with multiple missing covariates and partially observed responses. We develop a new framework to handle complex missing covariate scenarios via inverse probability weighting, regression adjustment, and a multiply-robust…

统计方法学 · 统计学 2021-11-04 Daniel Suen , Yen-Chi Chen

In this paper, we extend the vertical modeling approach for the analysis of survival data with competing risks to incorporate a cured fraction in the population, that is, a proportion of the population for which none of the competing events…

统计方法学 · 统计学 2015-08-18 M. A. Nicolaie , J. M. G. Taylor , C. Legrand

The semiparametric accelerated failure time model is not as widely used as the Cox relative risk model mainly due to computational difficulties. Recent developments in least squares estimation and induced smoothing estimating equations…

统计方法学 · 统计学 2015-06-02 Steven Chiou , Junghi Kim , Jun Yan

While analysing time-to-event data, it is possible that a certain fraction of subjects will never experience the event of interest and they are said to be cured. When this feature of survival models is taken into account, the models are…

统计方法学 · 统计学 2020-01-27 Khandoker Akib Mohammad , Yuichi Hirose , Budhi Surya , Yuan Yao

For statistical inference on regression models with a diverging number of covariates, the existing literature typically makes sparsity assumptions on the inverse of the Fisher information matrix. Such assumptions, however, are often…

统计方法学 · 统计学 2021-06-08 Lu Xia , Bin Nan , Yi Li

The relationship between a time-dependent covariate and survival times is usually evaluated via the Cox model. Time-dependent covariates are generally available as longitudinal data collected regularly during the course of the study. A…

统计理论 · 数学 2007-06-13 Jean-François Dupuy , Ion Grama , Mounir Mesbah

Analysis of competing risks data is often complicated by the incomplete or selectively missing information on the cause of failure. Standard approaches typically assume that the cause of failure is missing at random (MAR), an assumption…

Noncompliance and missing data often occur in randomized trials, which complicate the inference of causal effects. When both noncompliance and missing data are present, previous papers proposed moment and maximum likelihood estimators for…

统计方法学 · 统计学 2014-09-04 Hua Chen , Peng Ding , Zhi Geng , Xiao-Hua Zhou
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