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Estimating neuron location from extracellular recordings is essential for developing advanced brain-machine interfaces. Accurate neuron localization improves spike sorting, which involves detecting action potentials and assigning them to…

神经元与认知 · 定量生物学 2025-08-20 Hao Zhao , Xinhe Zhang , Arnau Marin-Llobet , Xinyi Lin , Jia Liu

As experiments advance to record from tens of thousands of neurons, statistical physics provides a framework for understanding how collective activity emerges from networks of fine-scale correlations. While modeling these populations is…

生物物理 · 物理学 2024-12-25 David P. Carcamo , Christopher W. Lynn

Complex networks datasets often come with the problem of missing information: interactions data that have not been measured or discovered, may be affected by errors, or are simply hidden because of privacy issues. This Element provides an…

物理与社会 · 物理学 2021-08-11 Giulio Cimini , Rossana Mastrandrea , Tiziano Squartini

We propose a Bayesian framework for uncertainty quantification and comparison in brain connectivity graph analysis. Standard graph-based approaches typically rely on point estimates of correlation matrices, overlooking the uncertainty…

统计方法学 · 统计学 2026-05-29 Alice Chevaux , Julyan Arbel , Guillaume Kon Kam King , Sophie Achard

The last decades saw dramatic progress in brain research. These advances were often buttressed by probing single variables to make circumscribed discoveries, typically through null hypothesis significance testing. New ways for generating…

神经元与认知 · 定量生物学 2019-03-26 Danilo Bzdok , John Ioannidis

The automated analysis of medical time series, such as the electrocardiogram (ECG), electroencephalogram (EEG), pulse oximetry, etc, has the potential to serve as a valuable tool for diagnostic decisions, allowing for remote monitoring of…

Humans and animals exhibit a range of interesting behaviors in dynamic environments, and it is unclear how our brains actively reformat this dense sensory information to enable these behaviors. Experimental neuroscience is undergoing a…

神经元与认知 · 定量生物学 2023-11-07 Aran Nayebi

Graphical models have been used extensively for modeling brain connectivity networks. However, unmeasured confounders and correlations among measurements are often overlooked during model fitting, which may lead to spurious scientific…

统计方法学 · 统计学 2020-12-10 Yanxin Jin , Yang Ning , Kean Ming Tan

Understanding the mechanisms of neural communication in large-scale brain networks remains a major goal in neuroscience. We investigated whether navigation is a parsimonious routing model for connectomics. Navigating a network involves…

神经元与认知 · 定量生物学 2018-06-05 Caio Seguin , Martijn P. van den Heuvel , Andrew Zalesky

There is growing interest in understanding how the structural interconnections among brain regions change with the occurrence of neurological diseases. Diffusion weighted MRI imaging has allowed researchers to non-invasively estimate a…

应用统计 · 统计学 2015-10-20 Daniele Durante , Madelaine Daianu , Neda Jahanshad , Paul M. Thompson , David B. Dunson

We propose a geometric model-free causality measurebased on multivariate delay embedding that can efficiently detect linear and nonlinear causal interactions between time series with no prior information. We then exploit the proposed causal…

神经与进化计算 · 计算机科学 2016-07-26 Saba Emrani , Hamid Krim

Causal discovery can be a powerful tool for investigating causality when a system can be observed but is inaccessible to experiments in practice. Despite this, it is rarely used in any scientific or medical fields. One of the major hurdles…

机器学习 · 统计学 2019-10-07 Erich Kummerfeld , Alexander Rix

We consider the problem of neural association for a network of non-binary neurons. Here, the task is to first memorize a set of patterns using a network of neurons whose states assume values from a finite number of integer levels. Later,…

神经与进化计算 · 计算机科学 2013-02-18 Amir Hesam Salavati , K. Raj Kumar , Amin Shokrollahi

Causal inference concerns the identification of cause-effect relationships between variables. However, often only linear combinations of variables constitute meaningful causal variables. For example, recovering the signal of a cortical…

统计方法学 · 统计学 2016-10-04 Sebastian Weichwald , Arthur Gretton , Bernhard Schölkopf , Moritz Grosse-Wentrup

Brain connectome analysis commonly compresses high-resolution brain scans (typically composed of millions of voxels) down to only hundreds of regions of interest (ROIs) by averaging within-ROI signals. This huge dimension reduction improves…

统计方法学 · 统计学 2025-03-25 Tong Lu , Yuan Zhang , Peter Kochunov , Elliot Hong , Shuo Chen

Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…

Learning the structure of a causal graphical model using both observational and interventional data is a fundamental problem in many scientific fields. A promising direction is continuous optimization for score-based methods, which,…

机器学习 · 计算机科学 2022-02-28 Phillip Lippe , Taco Cohen , Efstratios Gavves

Alzheimer's disease is the most common neurodegenerative disease. The aim of this study is to infer structural changes in brain connectivity resulting from disease progression using cortical thickness measurements from a cohort of…

As Artificial Intelligence (AI) models are increasingly integrated into critical systems, the need for a robust framework to establish the trustworthiness of AI is increasingly paramount. While collaborative efforts have established…

机器学习 · 计算机科学 2026-03-02 Haniyeh Ehsani Oskouie , Sajjad Ghiasvand , Lionel Levine , Majid Sarrafzadeh

Functional connectivity fingerprints are among today's best choices to obtain a faithful sampling of an individual's brain and cognition in health and disease. Here we make a case for key advantages of analyzing such connectome profiles…

统计方法学 · 统计学 2019-09-06 Danilo Bzdok , Dorothea L. Floris , Andre F. Marquand