相关论文: Negative local feedbacks in Boolean networks

Boolean networks at the critical point have been a matter of debate for many years as, e.g., scaling of number of attractor with system size. Recently it was found that this number scales superpolynomially with system size, contrary to a…

Identification of attractors, that is, stable states and sustained oscillations, is an important step in the analysis of Boolean models and exploration of potential variants. We describe an approach to the search for asynchronous cyclic…

We study two types of simple Boolean networks, namely two loops with a cross-link and one loop with an additional internal link. Such networks occur as relevant components of critical K=2 Kauffman networks. We determine mostly analytically…

Biological systems operate under persistent noise, which can alter system states and induce transitions between attractors. Here, we study the attractor dynamics of Boolean networks focusing on the transitions between attractors induced by…

We present a rigorous mathematical framework for analyzing dynamics of a broad class of Boolean network models. We use this framework to provide the first formal proof of many of the standard critical transition results in Boolean network…

We study the intrinsic properties of attractors in the Boolean dynamics in complex network with scale-free topology, comparing with those of the so-called random Kauffman networks. We have numerically investigated the frozen and relevant…

The problem of reliability of the dynamics in biological regulatory networks is studied in the framework of a generalized Boolean network model with continuous timing and noise. Using well-known artificial genetic networks such as the…

We study the target control problem of asynchronous Boolean networks, to identify a set of nodes, the perturbation of which can drive the dynamics of the network from any initial state to the desired steady state (or attractor). We are…

We consider the Cartesian product X of n finite intervals of integers and a map F from X to itself. As main result, we establish an upper bound on the number of fixed points for F which only depends on X and on the topology of the positive…

Networks of interacting nodes connected by edges arise in almost every branch of scientific enquiry. The connectivity structure of the network can force the existence of invariant subspaces, which would not arise in generic dynamical…

In the applications of Boolean networks to modeling biological systems, an important computational problem is the detection of the fixed points of these networks. This is an NP-complete problem in general. There have been various attempts…

A shifted or misaligned feedback loop gives rise to a two-point nonlocality that is the spatial analog of a temporal delay. Important consequences of this nonlocal coupling have been found both in diffusive and in diffractive systems, and…

We study the expressive power of positive neural networks. The model uses positive connection weights and multiple input neurons. Different behaviors can be expressed by varying the connection weights. We show that in discrete time, and in…

We derive asymptotic formulas for the Lyapunov exponent of almost all monotone Boolean networks. The formulas are different depending on whether the number of variables of the constituent Boolean functions, or equivalently, the connectivity…

Combinatorial threshold-linear networks (CTLNs) are a special class of inhibition-dominated TLNs defined from directed graphs. Like more general TLNs, they display a wide variety of nonlinear dynamics including multistability, limit cycles,…

We investigated the properties of Boolean networks that follow a given reliable trajectory in state space. A reliable trajectory is defined as a sequence of states which is independent of the order in which the nodes are updated. We…

This paper aims at setting the keystone of a prospective theoretical study on the role of non-monotone interactions in biological regulation networks. Focusing on discrete models of these networks, namely, Boolean automata networks, we…

Asynchronous Boolean networks are a type of discrete dynamical system in which each variable can take one of two states, and a single variable state is updated in each time step according to pre-selected rules. Boolean networks are popular…

To model biological systems using networks, it is desirable to allow more than two levels of expression for the nodes and to allow the introduction of parameters. Various modeling and simulation methods addressing these needs using Boolean…

Random Boolean networks have been used widely to explore aspects of gene regulatory networks. A modified form of the model through which to systematically explore the effects of increasing the number of gene states has previously been…