相关论文: A physical description of the adhesion and aggrega…
When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering…
Platelet adhesion and aggregation are essential for primary hemostasis, forming a clot that quickly stops initial bleeding. Despite this critical role, the dynamic interactions of platelet receptors with exposed collagen and von Willebrand…
We present the first mathematical model of flow-mediated primary hemostasis in an extravascular injury, which can track the process from initial deposition to occlusion. The model consists of a system of ordinary differential equations…
Red blood cells are known to form aggregates in the form of rouleaux. This aggregation process is believed to be reversible, but there is still no full understanding on the binding mechanism. There are at least two competing models, based…
During the formation of a thrombus, the architecture of the growing platelet aggregate is heterogeneous, with areas of dense and loosely packed platelets. The surface of activated platelets facilitate biochemical coagulation reactions that…
Continuous-flow ventricular assist devices (VADs) have been an increasingly common, life-saving therapy for advanced heart-failure patients, but elevate the risk of thrombosis due to a combination of non-physiological hemodynamics and…
Little is known about mechanics underlying the interaction among platelets during activation and aggregation. Although the strength of a blood thrombus has likely major biological importance, no previous study has measured directly the…
We investigate the aggregation kinetics of sedimenting particles theoretically and numerically, using the advection-diffusion equation. Agglomeration, caused by both transport mechanisms (diffusion and advection), is important for small…
A mathematical model of atherosclerosis of a blood vessel is advanced with regard for the entry of low-density lipoproteins (LDLs) into blood. For the first time, the influence of cytokines on the inflammation of a blood vessel at the…
Accumulation of particles while flowing past constrictions is a ubiquitous phenomenon observed in diverse systems. Some of the common examples are jamming of salt crystals near the orifice of salt shakers, clogging of filter systems,…
Microfluidic technology has emerged as a powerful tool for studying complex biological processes with enhanced precision and control. A microfluidic chip was designed to emulate human-like microvascular networks with precise control over…
Primary hemostasis is initiated by platelet adhesion and aggregation at a site of vascular injury and is strongly regulated by local hydrodynamic conditions. At elevated shear rates, platelet capture is mediated by von Willebrand factor…
Tissues are subjected to large external forces and undergo global deformations during morphogenesis. We use synthetic analogues of tissues to study the impact of cell-cell adhesion on the response of cohesive cellular assemblies under such…
We consider the dynamic wetting and dewetting processes of films and droplets of complex liquids on planar surfaces, focusing on the case of colloidal suspensions, where the particle interactions can be sufficiently attractive to cause…
Controlling bacterial surface adhesion and subsequent biofilm formation in fluid systems is crucial for the safety and efficacy of medical and industrial processes. Here, we theoretically examine the transport of bacteria close to surfaces,…
Atherosclerosis, a chronic inflammatory cardiovascular disease, leads to arterial constriction caused by the accumulation of lipids, cholesterol, and various substances within artery walls. Such plaque can rupture, resulting in a blood clot…
Through experimental studies, many details of the pathway of integrin $\alpha_{\rm IIb}\beta_3$ activation by ADP during the platelet aggregation process have been mapped out. ADP binds to two separate G protein coupled receptors on…
Thrombosis is a common complication following the surgical implantation of blood contacting devices, and is strongly influenced by the phenomenon of near-wall enrichment of platelets. This paper describes a multi-constituent continuum…
This paper worked towards modeling blood platelets. Blood platelets, also known as thrombocytes, play a key role in blood clotting which is a vital human function. Furthermore, the role of these entities in strokes, myocardial infarctions,…
The nonlinear rheological response of soft glassy materials is addressed experimentally by focusing on concentrated emulsions where interdroplet attraction is tuned through varying the surfactant content. Velocity profiles are recorded…