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A tracer particle is called anomalously diffusive if its mean squared displacement grows approximately as $\sigma^2 t^{\alpha}$ as a function of time $t$ for some constant $\sigma^2$, where the diffusion exponent satisfies $\alpha \neq 1$.…

软凝聚态物质 · 物理学 2018-10-17 Kui Zhang , Katelyn P. R. Crizer , Mark H. Schoenfisch , David B. Hill , Gustavo Didier

Recent advances in molecular biology and fluorescence microscopy imaging have made possible the inference of the dynamics of single molecules in living cells. Such inference allows to determine the organization and function of the cell. The…

应用统计 · 统计学 2018-06-20 Vincent Briane , Charles Kervrann , Myriam Vimond

Many physical and biological processes are modeled by "particles" undergoing L\'evy random walks. A feature of significant interest in these systems is the mean square displacement (MSD) of the particles. Long-time asymptotic approximations…

统计力学 · 物理学 2020-02-13 Christoph Borgers , Claude Greengard

Volume limitations and low yield thresholds of biological fluids have led to widespread use of passive microparticle rheology. The mean-squared-displacement (MSD) statistics of bead position time series (bead paths) are either applied…

We study the thermal Markovian diffusion of tracer particles in a 2D medium with spatially-varying diffusivity $D(r)$, mimicking recently measured, heterogeneous maps of the apparent diffusion coefficient in biological cells. For this…

统计力学 · 物理学 2014-12-24 Andrey G. Cherstvy , Aleksei V. Chechkin , Ralf Metzler

We study the mean-square displacement (MSD) of a tracer particle diffusing in a granular gas of inelastic hard spheres under homogeneous cooling state (HCS). Tracer and granular gas particles are in general mechanically different. Our…

统计力学 · 物理学 2026-01-29 Santos Bravo Yuste , Rubén Gómez González , Vicente Garzó

The mean-squared displacement (MSD) is an averaged quantity widely used to assess anomalous diffusion. In many cases, such as molecular motors with finite processivity, dynamics of the system of interest produce trajectories of varying…

统计力学 · 物理学 2020-10-07 Chapin S. Korosec , David A. Sivak , Nancy R. Forde

Nonergodicity observed in single-particle tracking experiments is usually modeled by transient trapping rather than spatial disorder. We introduce models of a particle diffusing in a medium consisting of regions with random sizes and random…

软凝聚态物质 · 物理学 2014-09-23 P. Massignan , C. Manzo , J. A. Torreno-Pina , M. F. García-Parajo , M. Lewenstein , G. J. Lapeyre

Anomalous diffusion has been widely observed by single particle tracking microscopy in complex systems such as biological cells. The resulting time series are usually evaluated in terms of time averages. Often anomalous diffusion is…

统计力学 · 物理学 2017-09-13 Stas Burov , Jae-Hyung Jeon , Ralf Metzler , Eli Barkai

We study the random walk of a particle in a compartmentalized environment, as realized in biological samples or solid state compounds. Each compartment is characterized by its length $L$ and the boundaries transmittance $T$. We identify two…

There have been increasing reports that the diffusion coefficient of macromolecules depends on time and fluctuates randomly. Here, a novel method to elucidate the fluctuating diffusivity from trajectory data is developed. The time-averaged…

统计力学 · 物理学 2017-10-25 Tomoshige Miyaguchi

Tracking of particles, be it a passive tracer or an actively moving bacterium in the growing bacterial colony, is a powerful technique to probe the physical properties of the environment of the particles. One of the most common measures of…

数据分析、统计与概率 · 物理学 2018-02-09 Wolfram Pönisch , Vasily Zaburdaev

Anomalous diffusion is frequently described by scaled Brownian motion (SBM), a Gaussian process with a power-law time dependent diffusion coefficient. Its mean squared displacement is $\langle x^2(t)\rangle\simeq\mathscr{K}(t)t$ with…

统计力学 · 物理学 2014-12-24 J. -H. Jeon , A. V. Chechkin , R. Metzler

The Mean Square Displacement is a central tool in the analysis of Single Particle Tracking experiments, shedding light on various biophysical phenomena. Frequently, parameters are extracted by performing time-averages on single particle…

生物物理 · 物理学 2013-05-24 Eldad Kepten Irena Bronshtein , Yuval Garini

We study the statistical properties of the time-averaged mean-square displacements (TAMSD). This is a standard non-local quadratic functional for inferring the diffusion coefficient from an individual random trajectory of a diffusing tracer…

统计力学 · 物理学 2020-01-03 Alexei Andreanov , Denis Grebenkov

Recent progresses in single particle tracking have shown evidences of non-Gaussian distribution of displacements in living cells, both near the cellular membrane and inside the cytoskeleton. A similar behavior has also been observed in…

生物物理 · 物理学 2019-05-30 Yann Lanoiselée , Denis S. Grebenkov

Microrheology is the study of the properties of a complex fluid through the diffusion dynamics of small particles, typically latex beads, moving through that material. Currently, it is the dominant technique in the study of the physical…

统计方法学 · 统计学 2012-02-13 Gustavo Didier , Scott McKinley , David B. Hill , John Fricks

In this article we present methods for measuring hindered Brownian motion in the confinement of complex 3D geometries using digital video microscopy. Here we discuss essential features of automated 3D particle tracking as well as diffusion…

流体动力学 · 物理学 2014-08-20 Simon L Dettmer , Ulrich F Keyser , Stefano Pagliara

We consider a classic two-state switching diffusion model from a single-particle tracking perspective. The mean and the variance of the time-averaged mean square displacement (TAMSD) are computed exactly. When the measurement time (i.e.,…

统计力学 · 物理学 2019-11-05 Denis S. Grebenkov

In a recent paper, Michael J. Saxton proposes to interpret as anomalous diffusion the occurrence of apparent transient sub-diffusive regimes in mean-squared displacements (MSD) plots, calculated from experimental trajectories of molecules…

亚细胞过程 · 定量生物学 2009-11-13 Nicolas Destainville , Aude Sauliere , Laurence Salome
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