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Ubiquitous to most molecular scattering methods is the challenge to retrieve bond distance and angle from the scattering signals since this requires convergence of pattern matching algorithms or fitting methods. This problem is typically…

Optical nanofibers provide a rich platform for exploring atomic and optical phenomena even when they support only a single spatial mode. Nanofibers supporting higher-order modes provide additional degrees of freedom to enable complex…

Strong-field photoelectron holography denotes the interference of various electron paths in laser-induced ionization of atoms, leading to interference patterns in the final momentum distribution. For a quantitative description of holography…

原子物理 · 物理学 2019-08-28 Simon Brennecke , Manfred Lein

We present a method for a real time visualization and automatic processing for detection and classification of untouched cancer cells in blood during stain free imaging flow cytometry using digital holographic microscopy and machine…

生物物理 · 物理学 2021-06-15 Noga Nissim , Matan Dudaie , Itay Barnea. , Natan T. Shaked

The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…

计算机视觉与模式识别 · 计算机科学 2025-07-10 Yutong Sun , Sichen Zhu , Peng Qiu

Diffraction analysis in four dimensional scanning transmission electron microscopy now enables the mapping of local structures including symmetry, strain, and polarization of materials. However, measuring the distribution of these…

材料科学 · 物理学 2024-06-19 Tim B. Eldred , Jacob G. Smith , Wenpei Gao

We propose a method for representing malignant lymphoma pathology images, from high-resolution cell nuclei to low-resolution tissue images, within a single hyperbolic space using self-supervised learning. To capture morphological changes…

计算机视觉与模式识别 · 计算机科学 2025-06-24 Kei Taguchi , Kazumasa Ohara , Tatsuya Yokota , Hiroaki Miyoshi , Noriaki Hashimoto , Ichiro Takeuchi , Hidekata Hontani

Three-dimensional imaging of biological cells is crucial for the investigation of cell biology, provide valuable information to reveal the mechanisms behind pathophysiology of cells and tissues. Recent advances in optical diffraction…

生物物理 · 物理学 2016-03-03 Kyoohyun Kim , Jonghee Yoon , Seungwoo Shin , SangYun Lee , Su-A Yang , YongKeun Park

We experimentally probe complex bio-photonic architecture of microstructures on the transparent insect wings by a simple, non-invasive, real time optical technique. A stable and reproducible far-field diffraction pattern in transmission was…

Modern imaging techniques at the molecular scale rely on utilizing novel coherent light sources like X-ray free electron lasers for the ultimate goal of visualizing such objects as individual biomolecules rather than crystals. Here, unlike…

Histopathology imaging is crucial for the diagnosis and treatment of skin diseases. For this reason, computer-assisted approaches have gained popularity and shown promising results in tasks such as segmentation and classification of skin…

Laser Doppler holography was introduced as a full-field imaging technique to measure blood flow in the retina and choroid with an as yet unrivaled temporal resolution. We here investigate separating the different contributions to the power…

医学物理 · 物理学 2021-06-02 Léo Puyo , Michel Paques , Mathias Fink , José-Alain Sahel , Michael Atlan

We report on wide-field imaging of pulsatile motion induced by blood flow using heterodyne holographic interferometry on the thumb of a healthy volunteer, in real-time. Optical Doppler images were measured with green laser light by a…

光学 · 物理学 2015-04-01 Jeffrey Bencteux , Pierre Pagnoux , Thomas Kostas , Sam Bayat , Michael Atlan

We present a system for measuring the amplitude and phase profiles of the pressure field of a harmonic acoustic wave with the goal of reconstructing the volumetric sound field. Unlike optical holograms that cannot be reconstructed exactly…

软凝聚态物质 · 物理学 2018-08-09 Hillary W. Gao , Kimberly I. Mishra , Annemarie Winters , Sidney Wolin , David G. Grier

We employ ptychography, a phase-retrieval imaging technique, to show experimentally for the first time that a partially coherent high-energy matter (electron) wave emanating from an extended source can be decomposed into a set of mutually…

介观与纳米尺度物理 · 物理学 2017-01-04 S. Cao , P. Kok , P. Li , A. M. Maiden , J. M. Rodenburg

Coherent diffraction imaging (CDI) allows the retrieval of the structure of an isolated object, such as a macromolecule, from its diffraction pattern. CDI requires the fulfilment of two conditions: the imaging radiation must be coherent and…

光学 · 物理学 2018-11-16 Tatiana Latychevskaia , Hans-Werner Fink

The accurate characterisation of the 3D deformations of slender fibres and thin sheets in flow, is a key experimental challenge in the study of particle-laden flows. We propose a high-resolution, single-camera method to visualise…

流体动力学 · 物理学 2026-03-18 Tymoteusz Miara , Draga Pihler-Puzović , Matthias Heil , Anne Juel

Visualizing individual charges confined to molecules and observing their dynamics with high spatial resolution is a challenge for advancing various fields in science, ranging from mesoscopic physics to electron transfer events in biological…

介观与纳米尺度物理 · 物理学 2016-09-19 Tatiana Latychevskaia , Flavio Wicki , Jean-Nicolas Longchamp , Conrad Escher , Hans-Werner Fink

Current in vivo microscopy allows us detailed spatiotemporal imaging (3D+t) of complete organisms and offers insights into their development on the cellular level. Even though the imaging speed and quality is steadily improving,…

图像与视频处理 · 电气工程与系统科学 2020-01-31 Sourabh Bhide , Ralf Mikut , Maria Leptin , Johannes Stegmaier

Optical diffraction tomography (ODT) has emerged as a powerful label-free three-dimensional (3D) bioimaging techniques for observing living cells and thin tissue layers. We report a new reflection-mode ODT (rODT) method for imaging thick…