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The proportion of false null hypotheses is a very important quantity in statistical modelling and inference based on the two-component mixture model and its extensions, and in control and estimation of the false discovery rate and false…

概率论 · 数学 2020-03-09 Xiongzhi Chen

Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any…

统计方法学 · 统计学 2011-11-16 Jianqing Fan , Xu Han , Weijie Gu

Much effort has been done to control the "false discovery rate" (FDR) when $m$ hypotheses are tested simultaneously. The FDR is the expectation of the "false discovery proportion" $\text{FDP}=V/R$ given by the ratio of the number of false…

统计理论 · 数学 2018-01-09 Marc Ditzhaus , Arnold Janssen

Inequalities are key tools to prove FDR control of a multiple test. The present paper studies upper and lower bounds for the FDR under various dependence structures of p-values, namely independence, reverse martingale dependence and…

统计理论 · 数学 2015-02-18 Philipp Heesen , Arnold Janssen

In the context of multiple hypotheses testing, the proportion $\pi_0$ of true null hypotheses in the pool of hypotheses to test often plays a crucial role, although it is generally unknown a priori. A testing procedure using an implicit or…

统计理论 · 数学 2009-02-17 Gilles Blanchard , Etienne Roquain

Multiple testing has been a popular topic in statistical research. Although vast works have been done, controlling the false discoveries remains a challenging task when the corresponding test statistics are dependent. Various methods have…

统计理论 · 数学 2022-07-05 Meng Mei , Tao Yu , Yuan Jiang

In the multiple testing context, a challenging problem is the estimation of the proportion $\pi_0$ of true-null hypotheses. A large number of estimators of this quantity rely on identifiability assumptions that either appear to be violated…

统计理论 · 数学 2008-12-18 Alain Celisse , Stéphane Robin

The probability of false discovery proportion (FDP) exceeding $\gamma\in[0,1)$, defined as $\gamma$-FDP, has received much attention as a measure of false discoveries in multiple testing. Although this measure has received acceptance due to…

统计理论 · 数学 2014-06-03 Wenge Guo , Li He , Sanat K. Sarkar

This research deals with massive multiple hypothesis testing. First regarding multiple tests as an estimation problem under a proper population model, an error measurement called Erroneous Rejection Ratio (ERR) is introduced and related to…

统计理论 · 数学 2007-06-13 Cheng Cheng

Multiple testing is a fundamental problem in high-dimensional statistical inference. Although many methods have been proposed to control false discoveries, it is still a challenging task when the tests are correlated to each other. To…

统计理论 · 数学 2022-07-06 Meng Mei , Yuan Jiang

Statistical dependence between hypotheses poses a significant challenge to the stability of large scale multiple hypotheses testing. Ignoring it often results in an unacceptably large spread in the false positive proportion even though the…

统计方法学 · 统计学 2018-10-15 Sairam Rayaprolu , Zhiyi Chi

Large-scale multiple testing with correlated and heavy-tailed data arises in a wide range of research areas from genomics, medical imaging to finance. Conventional methods for estimating the false discovery proportion (FDP) often ignore the…

统计方法学 · 统计学 2018-09-19 Jianqing Fan , Yuan Ke , Qiang Sun , Wen-Xin Zhou

Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any…

统计方法学 · 统计学 2010-12-21 Xu Han , Weijie Gu , Jianqing Fan

We investigate the performance of a family of multiple comparison procedures for strong control of the False Discovery Rate ($\mathsf{FDR}$). The $\mathsf{FDR}$ is the expected False Discovery Proportion ($\mathsf{FDP}$), that is, the…

统计理论 · 数学 2008-11-21 Pierre Neuvial

We show that the control of the false discovery rate (FDR) for a multiple testing procedure is implied by two coupled simple sufficient conditions. The first one, which we call ``self-consistency condition'', concerns the algorithm itself,…

统计理论 · 数学 2008-10-21 Gilles Blanchard , Etienne Roquain

When testing many hypotheses, often we do not have strong expectations about the directions of the effects. In some situations however, the alternative hypotheses are that the parameters lie in a certain direction or interval, and it is in…

统计方法学 · 统计学 2026-03-02 Jesse Hemerik

The present paper establishes new multiple procedures for simultaneous testing of a large number of hypotheses under dependence. Special attention is devoted to experiments with rare false hypotheses. This sparsity assumption is typically…

统计理论 · 数学 2019-10-01 Marc Ditzhaus , Arnold Janssen

Many statistical problems can be addressed by applying a multiple testing procedure (MTP) that controls either the Family-wise Error Rate (FWER) or False Discovery Rate (FDR) under unknown arbitrarily-interdependent $p$-values, without…

统计方法学 · 统计学 2026-05-21 George Karabatsos

Two recently introduced model based bias corrected estimators for proportion of true null hypotheses ($\pi_0$) under multiple hypotheses testing scenario have been restructured for exponentially distributed random observations available for…

统计理论 · 数学 2020-07-28 Aniket Biswas , Gaurangadeb Chattopadhyay , Aditya Chatterjee

Results on the false discovery rate (FDR) and the false nondiscovery rate (FNR) are developed for single-step multiple testing procedures. In addition to verifying desirable properties of FDR and FNR as measures of error rates, these…

统计理论 · 数学 2007-06-13 Sanat K. Sarkar
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