相关论文: Simulated Cytoskeletal Collapse via Tau Degradatio…

In the cellular phenomena of cytoplasmic streaming, molecular motors carrying cargo along a network of microtubules entrain the surrounding fluid. The piconewton forces produced by individual motors are sufficient to deform long…

Background: Beta-amyloid (A$\beta$) plaques and tau protein tangles in the brain are the defining 'A' and 'T' hallmarks of Alzheimer's disease (AD), and together with structural atrophy detectable on brain magnetic resonance imaging (MRI)…

The entanglement between two atoms in a damping Jaynes-Cummings model is investigated with different decay coefficients of the atoms from the upper level to other levels under detuning between the atomic frequency and the quantized light…

Topological insulators (TIs) are newly discovered states of matter with robust metallic surface states protected by the topological properties of the bulk wavefunctions. A quantum phase transition (QPT) from a TI to a conventional insulator…

Plasticity in hexagonal close packed (HCP) metals and alloys such as Titanium (Ti) and Zirconium (Zr) is carried out by the motion of $\langle a \rangle$ dislocations. Above room temperature, in situ transmission electron microscopy…

Bundles of stiff filaments are ubiquitous in the living world, found both in the cytoskeleton and in the extracellular medium. These bundles are typically held together by smaller cross-linking molecules. We demonstrate analytically,…

Accumulation of amyloid beta proteins is a defining feature of Alzheimer's disease, and is usually accompanied by cerebrovascular pathology. Evidence suggests that amyloid beta and cerebrovascular pathology are mutually reinforcing; in…

We systematically analyze the decay of metastable topological defects that arise from the spontaneous breakdown of gauge or global symmetries. Quantum-mechanical tunneling rates are estimated for a variety of decay processes. The decay rate…

Event-Based Models (EBMs) infer biomarker progression from cross-sectional data but typically only as ordinal sequences and rely on rigid model assumptions. We propose \textsc{Tempo}, a Transformer architecture that learns both ordinal and…

Dynamical reduction models propose a solution to the measurement problem in quantum mechanics: the collapse of the wave function becomes a physical process. We compute the predictions to decaying and Dynamical reduction models propose a…

To treat the problem of growing protoplanetary disc solids across the meter barrier, we consider a very simplified two-component coagulation-fragmentation model that consists of macroscopic boulders and smaller dust grains, the latter being…

In this study, a two-state mechanochemical model is presented to describe the dynamic instability of microtubules (MTs) in cells. The MTs switches between two states, assembly state and disassembly state. In assembly state, the growth of…

Aims: We determine the components of the $\Lambda$-effect tensor that quantifies the contributions to the turbulent momentum transport even for uniform rotation. Methods: Three-dimensional numerical simulations are used to study turbulent…

Many cellular processes rely on the cell's ability to transport material to and from the nucleus. Networks consisting of many microtubules and actin filaments are key to this transport. Recently, the inhibition of intracellular transport…

We propose a minimal model, based on active Brownian particles, for the dynamics of cells confined in a two-state micropattern, composed of two rectangular boxes connected by a bridge, and investigate the transition statistics. A transition…

We construct a finite dimensional Kaehler manifold with a holomorphic, symplectic circle action whose symplectic reduced spaces may be identified with the tau-vortex moduli spaces (or tau-stable pairs). The Morse theory of the circle action…

Fracture processes in multi-phase solids are inherently complex due to multiple competing mechanisms. Here, we investigate the elastic and fracture behaviour of two-phase solids, comprising a fragile phase and a tough phase using a…

This study employs three-dimensional particle-resolved simulations of planar shocks passing through a suspension of stationary solid particles to study wake-induced gas-phase velocity fluctuations, termed pseudo-turbulence. Strong coupling…

We examine in detail the semi-leptonic decay $\Lambda_b \to \Lambda_c \tau{\bar \nu}_{\tau}$, which may confirm previous hints, from the analogous $B$ decay, of a new physics beyond the standard model. First of all, starting from rather…

The disappearance of the guanosine triphosphate (GTP)-tubulin cap is widely believed to be the forerunner event for the growth-shrinkage transition (`catastrophe') in microtubule filaments in eukaryotic cells. We study a discrete version of…