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We study the robustness and stability of the yeast cell regulatory network by using a general inhomogeneous discrete model. We find that inhomogeneity, on average, enhances the stability of the biggest attractor of the dynamics and that the…

分子网络 · 定量生物学 2008-12-12 L. Wardil , J. K. L. da Silva

We consider diffusive lattice gases on a ring and analyze the stability of their density profiles conditionally to a current deviation. Depending on the current, one observes a phase transition between a regime where the density remains…

统计力学 · 物理学 2009-11-11 T. Bodineau , B. Derrida

In any Markov chain with finite state space the distribution of transition records always belongs to the exponential family. This observation is used to prove a fluctuation theorem, and to show that the dynamical entropy of a stationary…

统计力学 · 物理学 2009-11-11 Jan Naudts , Erik Van der Straeten

We provide a large deviations analysis of deadlock phenomena occurring in distributed systems sharing common resources. In our model transition probabilities of resource allocation and deallocation are time and space dependent. The process…

概率论 · 数学 2009-11-24 Francis Comets , Francois Delarue , René Schott

The contact process is an emblematic model of a non-equilibrium system, containing a phase transition between inactive and active dynamical regimes. In the epidemiological context, the model is known as the susceptible-infected-susceptible…

统计力学 · 物理学 2023-05-12 Wout Merbis , Clélia de Mulatier , Philippe Corboz

In ergodic physical systems, time-averaged quantities converge (for large times) to their ensemble-averaged values. Large deviation theory describes rare events where these time averages differ significantly from the corresponding ensemble…

统计力学 · 物理学 2020-05-20 Robert L. Jack

Active matter systems, from self-propelled colloids to motile bacteria, are characterized by the conversion of free energy into useful work at the microscopic scale. They involve physics beyond the reach of equilibrium statistical…

统计力学 · 物理学 2024-06-18 Nicholas M. Boffi , Eric Vanden-Eijnden

We introduce a statistical mechanics formalism for the study of constrained graph evolution as a Markovian stochastic process, in analogy with that available for spin systems, deriving its basic properties and highlighting the role of the…

无序系统与神经网络 · 物理学 2015-05-13 A. C. C. Coolen , A. De Martino , A. Annibale

We introduce and analyze two general dynamical models for unidirectional movement of particles along a circular chain and an open chain of sites. The models include a soft version of the simple exclusion principle, that is, as the density…

定量方法 · 定量生物学 2019-03-14 Eyal Bar-Shalom , Alexander Ovseevich , Michael Margaliot

In a physical system, changing parameters such as temperature can induce a phase transition: an abrupt change from one state of matter to another. Analogous phenomena have recently been observed in large language models. Typically, the task…

机器学习 · 计算机科学 2024-05-28 Julian Arnold , Flemming Holtorf , Frank Schäfer , Niels Lörch

Disease awareness in infection dynamics can be modeled with adaptive contact networks whose rewiring rules reflect the attempt by susceptibles to avoid infectious contacts. Simulations of this type of models show an active phase with…

适应与自组织系统 · 物理学 2012-12-06 Stefan Wieland , Tomas Aquino , Ana Nunes

A critical task in systems biology is the identification of genes that interact to control cellular processes by transcriptional activation of a set of target genes. Many methods have been developed to use statistical correlations in…

定量方法 · 定量生物学 2010-11-24 Adam A. Margolin , Kai Wang , Andrea Califano , Ilya Nemenman

Hybrid multiscale modelling has emerged as a useful framework for modelling complex biological phenomena. However, when accounting for stochasticity in the internal dynamics of agents, these models frequently become computationally…

定量方法 · 定量生物学 2021-05-11 Daria Stepanova , Helen M. Byrne , Philip K. Maini , Tomás Alarcón

Dynamical reaction-diffusion processes and meta-population models are standard modeling approaches for a wide variety of phenomena in which local quantities - such as density, potential and particles - diffuse and interact according to the…

统计力学 · 物理学 2007-05-23 V. Colizza , R. Pastor-Satorras , A. Vespignani

Metabolic heterogeneity is widely recognised as the next challenge in our understanding of non-genetic variation. A growing body of evidence suggests that metabolic heterogeneity may result from the inherent stochasticity of intracellular…

分子网络 · 定量生物学 2020-10-08 Mona K Tonn , Philipp Thomas , Mauricio Barahona , Diego A Oyarzún

We search for conditions under which a characteristic time scale for ordering dynamics towards either of two absorbing states in a finite complex network of interactions does not exist. With this aim, we study random networks and networks…

物理与社会 · 物理学 2009-11-13 R. Toivonen , X. Castelló , V. M. Eguíluz , J. Saramäki , K. Kaski , M. San Miguel

Complex networks have played an important role in describing real complex systems since the end of the last century. Recently, research on real-world data sets reports intermittent interaction among social individuals. In this paper, we pay…

社会与信息网络 · 计算机科学 2025-11-25 Ziyan Zeng , Minyu Feng , Jürgen Kurths

Human behaviour strongly influences the spread of infectious diseases: understanding the interplay between epidemic dynamics and adaptive behaviours is essential to improve response strategies to epidemics, with the goal of containing the…

物理与社会 · 物理学 2024-08-21 Marco Mancastroppa , Alessandro Vezzani , Vittoria Colizza , Raffaella Burioni

Infectious diseases are practically represented by models with multiple states and complex transition rules corresponding to, for example, birth, death, infection, recovery, disease progression, and quarantine. In addition, networks…

无序系统与神经网络 · 物理学 2007-05-23 Naoki Masuda , Norio Konno

Recent studies have investigated various dynamic processes characterizing collective behaviors in real-world systems. However, these dynamics have been studied individually in specific contexts. In this article, we present a holistic…

应用物理 · 物理学 2025-01-28 Ming Xie , Shibo He , Aming Li , Zike Zhang , Youxian Sun , Jiming Chen
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