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The field of complex self-assembly is moving toward the design of multi-particle structures consisting of thousands of distinct building blocks. To exploit the potential benefits of structures with such `addressable complexity,' we need to…

软凝聚态物质 · 物理学 2015-06-02 William M. Jacobs , Aleks Reinhardt , Daan Frenkel

In equilibrium self-assembly, microscopic building blocks spontaneously self-organize into stable structures as dictated by their interaction potentials, which limits the accessible structural features to those that correspond to global…

软凝聚态物质 · 物理学 2026-04-17 Pepijn G. Moerman , Chenghung Chou , Thomas E. Videbæk , W. Benjamin Rogers , Rebecca Schulman

The design space for a self-assembled multicomponent objects ranges from a solution in which every building block is unique to one with the minimum number of distinct building blocks that unambiguously define the target structure. Using a…

软凝聚态物质 · 物理学 2023-03-13 Joakim Bohlin , Andrew J. Turberfield , Ard A. Louis , Petr Šulc

DNA-coated particles are promising as building blocks for functional and finite-sized assemblies because they can be programmed with orthogonal interactions owing to the sequence-specific hybridization of DNA strands. To fully exploit this…

软凝聚态物质 · 物理学 2026-04-17 T. C. M. Stevens , A. van der Sluis , I. K. Voets , P. G. Moerman

The observation by Ke et al. [Science 338, 1177 (2012)] that large numbers of short, pre-designed DNA strands can assemble into three-dimensional target structures came as a great surprise, as no colloidal self-assembling system has ever…

软凝聚态物质 · 物理学 2014-06-12 Aleks Reinhardt , Daan Frenkel

In order to optimize a self-assembly reaction, it is essential to understand the factors that govern its pathway. Here, we examine the influence of nucleation pathways in a model system for addressable, multicomponent self-assembly based on…

软凝聚态物质 · 物理学 2018-08-01 Martin Sajfutdinow , William M. Jacobs , Aleks Reinhardt , Christoph Schneider , David M. Smith

The growth of multicomponent structures in simulations and experiments often results in kinetically trapped, nonequilibrium objects. In such cases we have no general theoretical framework for predicting the outcome of the growth process.…

软凝聚态物质 · 物理学 2016-08-10 Ranjan V. Mannige , Stephen Whitelam

Theories of phase change and self-assembly often invoke the idea of a `quasiequilibrium', a regime in which the nonequilibrium association of building blocks results nonetheless in a structure whose properties are determined solely by an…

统计力学 · 物理学 2013-07-22 Stephen Whitelam , Rebecca Schulman , Lester Hedges

We investigate general properties of non-deterministic self-assembly with asymmetric interactions, using a computational model and DNA tile assembly experiments. By contrasting symmetric and asymmetric interactions we show that the latter…

软凝聚态物质 · 物理学 2016-08-24 S. Tesoro , K. Göpfrich , T. Kartanas , U. F. Keyser , S. E. Ahnert

Patterns and forms adopted by Nature, such as the shape of living cells, the geometry of shells and the branched structure of plants, are often the result of simple dynamical paradigms. Here we show that a growing self-interacting string…

软凝聚态物质 · 物理学 2009-11-11 D. Marenduzzo , T. X. Hoang , F. Seno , M. Vendruscolo , A. Maritan

Over the last decade, the field of programmable self-assembly has seen an explosion in the diversity of crystal lattices that can be synthesized from DNA-coated colloidal nanometer- and micrometer-scale particles. The prevailing wisdom has…

We use analytic theory and computer simulation to study patterns formed during the growth of two-component assemblies in 2D and 3D. We show that these patterns undergo a nonequilibrium phase transition, at a particular growth rate, between…

统计力学 · 物理学 2014-05-12 Stephen Whitelam , Lester O. Hedges , Jeremy D. Schmit

Self-assembly in the laboratory can now yield `information-rich' nanostructures in which each component is of a distinct type and has a defined spatial position. Ensuring the thermodynamic stability of such structures requires…

生物物理 · 物理学 2016-03-22 Stephen Whitelam

We report Monte Carlo simulations of a simple off-lattice patchy-particle model for DNA `bricks'. We relate the parameters that characterise this model with the binding free energy of pairs of single-stranded DNA molecules. We verify that…

软凝聚态物质 · 物理学 2016-07-21 Aleks Reinhardt , Daan Frenkel

A hallmark of living systems is the ability to employ a common set of versatile building blocks that can self-organize into a multitude of different structures, in a way that can be controlled with minimal cost. This capability can only be…

统计力学 · 物理学 2022-01-26 Saeed Osat , Ramin Golestanian

We report canonical and grand-canonical lattice Monte Carlo simulations of the self-assembly of addressable structures comprising hundreds of distinct component types. The nucleation behaviour, in the form of free-energy barriers to…

软凝聚态物质 · 物理学 2016-04-18 Aleks Reinhardt , Chon Pan Ho , Daan Frenkel

Inverse design can be a useful strategy for discovering interactions that drive particles to spontaneously self-assemble into a desired structure. Here, we extend an inverse design methodology--relative entropy optimization--to determine…

软凝聚态物质 · 物理学 2018-03-16 William D. Piñeros , Beth A. Lindquist , Ryan B. Jadrich , Thomas M. Truskett

We use computer simulation to study the layer-by-layer growth of particle structures in a lattice gas, taking the number of incorporated vacancies as a measure of the quality of the grown structure. By exploiting a dynamic scaling relation…

统计力学 · 物理学 2017-08-07 Stephen Whitelam

Recent advancements in microbiology have motivated the study of the production of nanostructures with applications such as biomedical computing and molecular robotics. One way to construct these structures is to construct branched DNA…

We devise an inverse statistical-mechanical methodology to find optimized interaction potentials that lead spontaneously to a target many-particle configuration. Target structures can possess varying degrees of disorder, thus extending the…

软凝聚态物质 · 物理学 2009-11-11 Mikael Rechtsman , Frank Stillinger , Salvatore Torquato
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