Algorithmic Pot Generation: Algorithms for the Flexible-Tile Model of DNA Self-Assembly
Combinatorics
2024-08-02 v1
Abstract
Recent advancements in microbiology have motivated the study of the production of nanostructures with applications such as biomedical computing and molecular robotics. One way to construct these structures is to construct branched DNA molecules that bond to each other at complementary cohesive ends. One practical question is: given a target nanostructure, what is the optimal set of DNA molecules that assemble such a structure? We use a flexible-tile graph theoretic model to develop several algorithmic approaches, including a integer programming approach. These approaches take a target undirected graph as an input and output an optimal collection of component building blocks to construct the desired structure.
Cite
@article{arxiv.2408.00192,
title = {Algorithmic Pot Generation: Algorithms for the Flexible-Tile Model of DNA Self-Assembly},
author = {Jacob Ashworth and Luca Grossmann and Fausto Navarro and Leyda Almodovar and Amanda Harsy and Cory Johnson and Jessica Sorrells},
journal= {arXiv preprint arXiv:2408.00192},
year = {2024}
}
Comments
43 pages, 11 figures,