Computational complexity and pragmatic solutions for flexible tile based DNA self-assembly
Abstract
Branched junction molecule assembly of DNA nanostructures, pioneered by Seeman's laboratory in the 1980s, has become increasingly sophisticated, as have the assembly targets. A critical design step is finding minimal sets of branched junction molecules that will self-assemble into target structures without unwanted substructures forming. We use graph theory, which is a natural design tool for self-assembling DNA complexes, to address this problem. After determining that finding optimal design strategies for this method is generally NP-complete, we provide pragmatic solutions in the form of programs for special settings and provably optimal solutions for natural assembly targets such as platonic solids, regular lattices, and nanotubes. These examples also illustrate the range of design challenges.
Cite
@article{arxiv.2108.00035,
title = {Computational complexity and pragmatic solutions for flexible tile based DNA self-assembly},
author = {Leyda Almodóvar and Jo Ellis-Monaghan and Amanda Harsy and Cory Johnson and Jessica Sorrells},
journal= {arXiv preprint arXiv:2108.00035},
year = {2021}
}
Comments
41 pages, 30 figures