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The impact of thermal fluctuations on the translocation dynamics of a polymer chain driven through a narrow pore has been investigated theoretically and by means of extensive Molecular-Dynamics (MD) simulation. The theoretical consideration…

软凝聚态物质 · 物理学 2015-06-12 J. L. A. Dubbeldam , V. G. Rostiashvili , A. Milchev , T. A. Vilgis

We investigate the dynamics of polymer translocation through nanopores under external driving by 3D Langevin Dynamics simulations, focusing on the scaling of the average translocation time $\tau$ versus the length of the polymer, $\tau\sim…

软凝聚态物质 · 物理学 2010-01-04 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Ralf Metzler

Motivated by identifying the origin of the bias dependence of tension propagation we investigate methods for measuring tension propagation quantitatively in computer simulations of driven polymer translocation. Here the motion of flexible…

生物物理 · 物理学 2017-12-18 P. M. Suhonen , J. Piili , R. P. Linna

We study translocation of semiflexible polymers driven by force $f_d$ inside a nanometer-scale pore using our three-dimensional Langevin dynamics model. We show that the translocation time $\tau$ increases with increasing bending rigidity…

生物物理 · 物理学 2018-06-27 Pauli M. Suhonen , Riku P. Linna

We present event distributions for the polymer translocation obtained by extensive Langevin dynamics simulations. Such distributions have not been reported previously and they provide new understanding of the stochastic characteristics of…

软凝聚态物质 · 物理学 2012-04-13 R. P. Linna , K. Kaski

By analyzing the real space nonequilibrium dynamics of polymers, we elucidate the physics of driven translocation and propose its dynamical scaling scenario analogous to that in the surface growth phenomena. We provide a detailed account of…

软凝聚态物质 · 物理学 2011-11-28 Takuya Saito , Takahiro Sakaue

We study the driven translocation of a flexible polymer through an interacting conical pore using Langevin dynamics simulations. We find that, for a fixed value of externally applied force and pore polymer interaction strength, the mean…

软凝聚态物质 · 物理学 2021-02-17 Rajneesh Kumar , Abhishek Chaudhuri , Rajeev Kapri

Polymer translocation has long been a topic of interest in the field of biological physics given its relevance in both biological (protein and DNA/RNA translocation through nuclear and cell membranes) and technological processes (nanopore…

软凝聚态物质 · 物理学 2023-09-11 Alejandro Sainz-Agost , Fernando Falo , Alessandro Fiasconaro

We suggest a governing equation which describes the process of polymer chain translocation through a narrow pore and reconciles the seemingly contradictory features of such dynamics: (i) a Gaussian probability distribution of the…

软凝聚态物质 · 物理学 2011-02-15 Johan L. A. Dubbeldam , V. G. Rostiashvili , A. Milchev , T. A. Vilgis

We suggest a theoretical description of the force-induced translocation dynamics of a polymer chain through a nanopore. Our consideration is based on the tensile (Pincus) blob picture of a pulled chain and the notion of propagating front of…

软凝聚态物质 · 物理学 2012-04-17 J. L. A. Dubbeldam , V. G. Rostiashvili , A. Milchev , T. A. Vilgis

We consider the dynamics of pore-driven polymer translocation through a nanopore to semi-infinite space when the chain is initially confined and equilibrated in a narrow channel. To this end, we use Langevin dynamics (LD) simulations and…

软凝聚态物质 · 物理学 2025-03-11 Soheila Emamyari , Jalal Sarabadani , Ralf Metzler , Tapio Ala-Nissila

The theoretical formulation of driven polymer translocation through nanopores is complicated by the combination of the pore electrohydrodynamics and the nonequilibrium polymer dynamics originating from the conformational polymer…

软凝聚态物质 · 物理学 2019-01-15 Sahin Buyukdagli , Jalal Sarabadani , Tapio Ala-Nissila

We investigate the dynamics of pore-driven polymer translocation by theoretical analysis and molecular dynamics (MD) simulations. Using the tension propagation theory within the constant flux approximation we derive an explicit equation of…

软凝聚态物质 · 物理学 2015-06-23 Jalal Sarabadani , Timo Ikonen , Tapio Ala-Nissila

We present a numerical study of forced polymer translocation by using two separate pore models. Both of them have been extensively used in previous forced translocation studies. We show that variations in the pore model affect the forced…

生物物理 · 物理学 2015-05-19 V. V. Lehtola , K. Kaski , R. P. Linna

We investigate the dynamics of polymer translocation through a nanopore using two-dimensional Langevin dynamics simulations. In the absence of external driving force, we consider a polymer which is initially placed in the middle of the pore…

软凝聚态物质 · 物理学 2007-05-23 Ilkka Huopaniemi , Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying

In forced polymer translocation, the average translocation time, $\tau$, scales with respect to pore force, $f$, and polymer length, $N$, as $\tau \sim f^{-1} N^{\beta}$. We demonstrate that an artifact in Metropolis Monte Carlo method…

生物物理 · 物理学 2009-11-13 V. V. Lehtola , R. P. Linna , K. Kaski

We consider the passage of long polymers of length N through a hole in a membrane. If the process is slow, it is in principle possible to focus on the dynamics of the number of monomers s on one side of the membrane, assuming that the two…

软凝聚态物质 · 物理学 2009-11-10 Yacov Kantor , Mehran Kardar

We investigate several scaling properties of a translocating homopolymer through a thin pore driven by an external field present inside the pore only using Langevin Dynamics (LD) simulation in three dimension (3D). Specifically motivated by…

We study the driven translocation of a semi-flexible polymer through a nanopore by means of a modified version of the iso-flux tension propagation theory (IFTP), and extensive molecular dynamics (MD) simulations. We show that in contrast to…

软凝聚态物质 · 物理学 2016-12-28 Jalal Sarabadani , Timo Ikonen , Harri Mökkönen , Tapio Ala-Nissila , Spencer Carson , Meni Wanunu

Iso-flux tension propagation (IFTP) theory and Langevin dynamics (LD) simulations are employed to study the dynamics of channel-driven polymer translocation in which a polymer translocates into a narrow channel and the monomers in the…

软凝聚态物质 · 物理学 2022-05-16 Jalal Sarabadani , Ralf Metzler , Tapio Ala-Nissila
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