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Much effort has been done to control the "false discovery rate" (FDR) when $m$ hypotheses are tested simultaneously. The FDR is the expectation of the "false discovery proportion" $\text{FDP}=V/R$ given by the ratio of the number of false…

统计理论 · 数学 2018-01-09 Marc Ditzhaus , Arnold Janssen

Signal identification in large-dimensional settings is a challenging problem in biostatistics. Recently, the method of higher criticism (HC) was shown to be an effective means for determining appropriate decision thresholds. Here, we study…

统计方法学 · 统计学 2012-12-21 Bernd Klaus , Korbinian Strimmer

We propose a general and flexible procedure for testing multiple hypotheses about sequential (or streaming) data that simultaneously controls both the false discovery rate (FDR) and false nondiscovery rate (FNR) under minimal assumptions…

统计方法学 · 统计学 2019-01-14 Jay Bartroff , Jinlin Song

Obtaining high-quality labels for large datasets is expensive, requiring massive annotations from human experts. While AI models offer a cost-effective alternative by predicting labels, their label quality is compromised by the unavoidable…

机器学习 · 计算机科学 2026-02-17 Huipeng Huang , Wenbo Liao , Huajun Xi , Hao Zeng , Mengchen Zhao , Hongxin Wei

Correlation networks are commonly used to infer associations between microbes and metabolites. The resulting p-values are then corrected for multiple comparisons using existing methods such as the Benjamini and Hochberg procedure to control…

统计方法学 · 统计学 2025-06-17 Jing Ma

We address a common problem in large-scale data analysis, and especially the field of genetics, the huge-scale testing problem, where millions to billions of hypotheses are tested together creating a computational challenge to perform…

统计方法学 · 统计学 2015-01-22 Vered Madar , Sandra Batista

In many scenarios such as genome-wide association studies where dependences between variables commonly exist, it is often of interest to infer the interaction effects in the model. However, testing pairwise interactions among millions of…

统计方法学 · 统计学 2022-09-02 Jingyi Duan , Yang Ning , Xi Chen , Yong Chen

The recent e-Benjamini-Hochberg (e-BH) procedure for multiple hypothesis testing is known to control the false discovery rate (FDR) under arbitrary dependence between the input e-values. This paper points out an important subtlety when…

统计方法学 · 统计学 2025-08-06 Hongjian Wang , Sanjit Dandapanthula , Aaditya Ramdas

False discovery rate (FDR) is a commonly used criterion in multiple testing and the Benjamini-Hochberg (BH) procedure is arguably the most popular approach with FDR guarantee. To improve power, the adaptive BH procedure has been proposed by…

统计方法学 · 统计学 2023-10-11 Zijun Gao

We propose sequential multiple testing procedures which control the false discover rate (FDR) or the positive false discovery rate (pFDR) under arbitrary dependence between the data streams. This is accomplished by "optimizing" an upper…

统计方法学 · 统计学 2024-11-27 Michael Hankin , Jay Bartroff

Selecting the top-$m$ variables with the $m$ largest population parameters from a larger set of candidates is a fundamental problem in statistics. In this paper, we propose a novel methodology called Sequential Correct Screening (SCS),…

统计方法学 · 统计学 2025-08-21 Masaki Toyoda , Yoshimasa Uematsu

Identifying areas where the signal is prominent is an important task in image analysis, with particular applications in brain mapping. In this work, we develop confidence regions for spatial excursion sets above and below a given level. We…

统计方法学 · 统计学 2025-04-18 Howon Ryu , Thomas Maullin-Sapey , Armin Schwartzman , Samuel Davenport

This paper introduces the \texttt{FDR-linking} theorem, a novel technique for understanding \textit{non-asymptotic} FDR control of the Benjamini--Hochberg (BH) procedure under arbitrary dependence of the $p$-values. This theorem offers a…

统计理论 · 数学 2018-12-24 Weijie J. Su

Online testing procedures aim to control the extent of false discoveries over a sequence of hypothesis tests, allowing for the possibility that early-stage test results influence the choice of hypotheses to be tested in later stages.…

统计方法学 · 统计学 2021-10-18 Aaron Fisher

The False Discovery Rate (FDR) is a commonly used type I error rate in multiple testing problems. It is defined as the expected False Discovery Proportion (FDP), that is, the expected fraction of false positives among rejected hypotheses.…

统计理论 · 数学 2013-10-04 Pierre Neuvial

This work investigates multiple testing by considering minimax separation rates in the sparse sequence model, when the testing risk is measured as the sum FDR+FNR (False Discovery Rate plus False Negative Rate). First using the popular…

统计理论 · 数学 2023-08-31 Kweku Abraham , Ismael Castillo , Etienne Roquain

Multiple tests are designed to test a whole collection of null hypotheses simultaneously. Their quality is often judged by the false discovery rate (FDR), i.e. the expectation of the quotient of the number of false rejections divided by the…

统计理论 · 数学 2015-11-24 Julia Benditkis , Philipp Heesen , Arnold Janssen

In many applications, the process of identifying a specific feature of interest often involves testing multiple hypotheses for their joint statistical significance. Examples include mediation analysis which simultaneously examines the…

统计方法学 · 统计学 2023-05-30 Linsui Deng , Kejun He , Xianyang Zhang

In the spirit of modeling inference for microarrays as multiple testing for sparse mixtures, we present a similar approach to a simplified version of quantitative trait loci (QTL) mapping. Unlike in case of microarrays, where the number of…

统计理论 · 数学 2008-12-18 Małgorzata Bogdan , Jayanta K. Ghosh , Surya T. Tokdar

Since Benjamini and Hochberg introduced false discovery rate (FDR) in their seminal paper, this has become a very popular approach to the multiple comparisons problem. An increasingly popular topic within functional data analysis is local…

统计方法学 · 统计学 2019-08-16 Niels Lundtorp Olsen , Alessia Pini , Simone Vantini