相关论文: Ending AIDS in Gabon: How long will it take? How m…

In most countries CD4+ cell counts are still used for deciding when to start HIV-positive people on anti-retroviral therapy. However, various CD4+ thresholds, 200, 350 or 500/\muL, are chosen arbitrarily and for historical reasons. Here we…

Anti-retroviral drugs can reduce the infectiousness of people living with HIV by about 96%--treatment as prevention or TasP--and can reduce the risk of being infected by an HIV positive person by about 70%--pre-exposure prophylaxis or…

A simple deterministic model is proposed to represent the basic aspects concerning the effects of different antiretroviral treatment schedules on HIV incidence and prevalence of affected populations. The model mimics current treatment…

Pre-exposure prophylaxis (PrEP) consists in the use of an antiretroviral medication to prevent the acquisition of HIV infection by uninfected individuals and has recently demonstrated to be highly efficacious for HIV prevention. We propose…

South Africa has the greatest number of people living with HIV in the world but the direct impact of this on the public health system has not been directly measured. Using data from the Chris Hani Baragwanath Hospital, the largest hospital…

Sexual contacts are the main spreading route of HIV. This puts sex workers at higher risk of infection even in populations where HIV prevalence is moderate or low. Alongside condom use, Pre-Exposure Prophylaxis (PrEP) is an effective tool…

A two-sex Basic Reproduction Number (BRN) is used to investigate the conditions under which the Human Immunodeficiency Virus (HIV) may spread through heterosexual contacts in Sub-Saharan Africa. (The BRN is the expected number of new…

When comparing time-varying treatments in a non-randomised setting, one must often correct for time-dependent confounders that influence treatment choice over time and that are themselves influenced by treatment. We present a new two step…

It is now evident that the commonly accepted strategy for treatment of HIV/AIDS by highly active antiretroviral therapy (HAART) will not lead to eradication of HIV in a reasonable time. This is straightforward from the typical exponential…

The concentration of CD4 T-lymphocytes (CD4 count), in a person's plasma is widely used to decide when to start HIV-positive people on anti-retroviral therapy (ART) and to predict the impact of ART on the future course of HIV and…

This study utilizes mathematical models to assess progress toward achieving the UNAIDS 90-90-90 and 95-95-95 targets aimed at managing and eradicating HIV/AIDS. It contrasts stochastic and deterministic models, focusing on their utility in…

We establish a stochastic HIV/AIDS model for the individuals with protection awareness and reveal how the protection awareness plays its important role in the control of AIDS. We firstly show that there exists a global positive solution for…

Understanding historical trends in the epidemic of HIV is important for assessing current and projecting future trends in prevalence, incidence and mortality and for evaluating the impact and cost-effectiveness of control measures. In…

Treating and preventing Human Immunodeficiency Virus (HIV) remains a critical global health challenge. While antiretroviral therapy provides a path toward viral suppression -- effectively eliminating an individual's transmission risk --…

In this article, we propose a network spread model for HIV epidemics, wherein each individual is represented by a node of the transmission network and the edges are the connections between individuals along which the infection may spread.…

The HIV/AIDS pandemic is a global issue that has unequally affected several countries. Due to the complexity of this condition and the human drama it represents to those most affected by it, several fields have contributed to solving or at…

With a 676% growth rate in HIV incidence between 2010 and 2021, the HIV/AIDS epidemic in the Philippines is the one that is spreading the quickest in the western Pacific. Although the full effects of COVID-19 on HIV services and development…

Background: High HIV transmission persists in many U.S. jurisdictions despite prevention efforts. HIV self-testing offers a means to overcome barriers associated with routine laboratory-based testing but carries a risk of increasing…

Since the early 2000s, evidence has accumulated for a significant differential effect of first-line antiretroviral therapy (ART) regimens on human immunodeficiency virus (HIV) viral load suppression. This finding was replicated in our data…

Massive research efforts are now underway to develop a cure for HIV infection, allowing patients to discontinue lifelong combination antiretroviral therapy (ART). New latency-reversing agents (LRAs) may be able to purge the persistent…