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Electroporation is a very useful tool for drug delivery into various diseased tissues of the human body. This technique helps to improve the clinical treatment by transferring drugs into the targeted cells rapidly. In electroporation, drug…

泛函分析 · 数学 2022-08-03 Nilay Mondal , D. C. Dalal

We study a phenomenological electropermeabilization model in a periodic medium representing biological tissue. Starting from a cell-level model describing the electric potential and the degree of porosity, we perform dimension analysis to…

偏微分方程分析 · 数学 2026-02-03 Tobias Gebäck , Ioanna Motschan-Armen , Irina Pettersson

A molecular dynamics (MD) simulation is used to quantitatively analyze the induced membrane potential for an applied external field varied between 0.4 V/nm to 2.0 V/nm. The change in the electrostatic potential in the DPPC is directly…

生物物理 · 物理学 2023-11-02 Shadeeb Hossain

This paper presents a model and numerical analysis (simulations) of transmembrane potential induced in biological cell membrane under the influence of externally applied electric field (i.e., electroporation). This model differs from the…

生物物理 · 物理学 2009-11-13 Pratip Shil , Salil Bidaye , Pandit B. Vidyasagar

Five parameters of a model of a polymer electrolyte membrane fuel cell cathode (the porosity of the gas diffusion layer, the porosity of the catalyst layer, the exchange current density of the oxygen reduction reaction, the effective ionic…

材料科学 · 物理学 2013-08-22 Qingzhi Guo , Vijay A. Sethuraman , Ralph E. White

This paper investigates the problem of electrophoretic motion of a polyelectrolyte capsule with a porous arbitrary charged conducting shell in an electrolyte under the action of an external electric field. The corresponding boundary value…

流体动力学 · 物理学 2021-08-11 Anatoly N. Filippov , Daria Yu. Khanukaeva , Petr A. Aleksandrov

Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversible tissue electroporation is presented for…

泛函分析 · 数学 2022-08-03 Nilay Mondal , D. C. Dalal

Standard model of electropration (EP) has long emphasized a single pore lifetime to explain post-pulse transport across cell membranes. However, pore lifetimes estimated from molecular dynamics (MD) models and and those measured from…

生物物理 · 物理学 2017-10-11 Thiruvallur R. Gowrishankar , Julie V. Stern , James C. Weaver

A new model for the interaction of an electric pulse with a lipid membrane is proposed. Using this model we show that when a DC electric pulse is applied to an insulating lipid membrane separating fluids with different conductivities, the…

生物物理 · 物理学 2015-05-18 Jonathan T. Schwalbe , Petia M. Vlahovska , Michael J. Miksis

Electric-field-driven electrolyte transport through nanoporous membranes is important for applications including osmotic power generation, sensing and iontronics. We derive an analytical equation in the Debye--H\"uckel regime and a…

软凝聚态物质 · 物理学 2026-05-01 Holly C. M. Baldock , David M. Huang

Liquid transport through nanopore is central into many applications, from water purification to biosensing or energy harvesting. Ultimately thin nanopores are of major interest in these applications to increase driving potential and reduce…

流体动力学 · 物理学 2020-10-05 Olivier Liot , Catherine Sempere , Christophe Ybert , Anne-Laure Biance

Porous electrodes are found in energy storage devices such as supercapacitors and pseudocapacitors. However, the effect of electrode-pore-size distribution over their energy storage properties remains unclear. Here, we develop a model for…

化学物理 · 物理学 2021-12-03 Filipe Henrique , Pawel J. Zuk , Ankur Gupta

Electroporation method is a useful tool for delivering drugs into various diseased tissues in the human body. As a result of an applied electric field, drug particles enter the intracellular compartment through the temporarily permeabilized…

组织与器官 · 定量生物学 2022-08-10 Nilay Mondal , K. S. Yadav , D. C. Dalal

Three-terminal electrochemical ionic synapses (EIoS) have recently attracted interest for in-memory computing applications. These devices utilize electrochemical ion intercalation to modulate the ion concentration in the channel material.…

介观与纳米尺度物理 · 物理学 2025-08-01 Michael L. Li , Dingyu Shen , Jesus A. del Alamo , Martin Z. Bazant

A three-dimensional model of a single-layer lithium-ion pouch cell is presented which couples conventional porous electrode theory describing cell electrochemical behaviour with an energy balance describing cell thermal behaviour.…

应用物理 · 物理学 2020-05-12 Robert Timms , Scott G. Marquis , Valentin Sulzer , Colin Please , S. Jon Chapman

The unified 3D phase-field model for the description of the lithium-ion cell as a whole is developed. The model takes into account the realistic distribution of particles in porous electrodes, percolative transport of ions, and the…

无序系统与神经网络 · 物理学 2021-05-11 Pavel E. L'vov , Mikhail Yu. Tikhonchev , Renat T. Sibatov

Continuum simulation is employed to study ion transport and fluid flow through a nanopore in a solid-state membrane under an applied potential drop. Results show the existence of concentration polarization layers on the surfaces of the…

流体动力学 · 物理学 2015-06-16 Mao Mao , Sandip Ghosal , Guohui Hu

Electroporation of biological cell membranes is a phenomena that occurs almost universally at a transmembrane potential of approximately 1000 mV. Theories of pore formation have been proposed based on electrocompression (Crowley 1972,…

生物物理 · 物理学 2007-05-23 William A Hercules , James Lindesay , Anna Coble

Numerical simulations are a powerful tool for the development and improvement of Li-ion batteries. Modeling the mass transport of the involved electrolytic solutions requires precise determination of the corresponding electrolyte…

化学物理 · 物理学 2024-11-21 Lukas Lehnert , Maryam Nojabaee , Arnulf Latz , Birger Horstmann

Unassisted ion transport through lipid membranes plays a crucial role in many cell functions without which life would not be possible, yet the precise mechanism behind the process remains unknown due to its molecular complexity. Here, we…

软凝聚态物质 · 物理学 2022-07-25 David Roesel , Maksim Eremchev , Chetan S. Poojari , Jochen S. Hub , Sylvie Roke
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