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In this article, we develop a mathematical model for the rotary bacterial flagellar motor (BFM) based on the recently discovered structure of the stator complex (MotA$_5$MotB$_2$). The structure suggested that the stator also rotates. The…

软凝聚态物质 · 物理学 2022-02-15 Yuansheng Cao , Tairan Li , Yuhai Tu

The bacterial flagellar motor drives the rotation of flagellar filaments and enables many species of bacteria to swim. Torque is generated by interaction of stator units, anchored to the peptidoglycan cell wall, with the rotor. Recent…

亚细胞过程 · 定量生物学 2010-08-18 G. Meacci , Y. Tu

The bacterial flagellar motor (BFM) is responsible for driving bacterial locomotion and chemotaxis, fundamental processes in pathogenesis and biofilm formation. In the BFM, torque is generated at the interface between transmembrane proteins…

生物物理 · 物理学 2016-02-17 Kranthi K. Mandadapu , Jasmine A. Nirody , Richard M. Berry , George Oster

The bacterial flagellar motor is an ion-powered transmembrane protein complex which drives swimming in many bacterial species. The motor consists of a cytoplasmic 'rotor' ring and a number of 'stator' units, which are bound to the cell wall…

生物物理 · 物理学 2020-06-17 Jasmine A Nirody , Ashley L. Nord , Richard M. Berry

The bacterial flagellar motor (BFM) converts transmembrane ion flux into directed mechanical rotation, driving bacterial motility. Despite extensive study, the frictional forces and energetics governing its torque generation remain poorly…

生物物理 · 物理学 2025-12-18 N. J. Lopez-Alamilla , A. L. Nord , F. Pedaci , J. Palmeri , N. -O. Walliser

Many swimming bacteria are propelled by flagellar motors that stochastically switch between the clockwise and counterclockwise rotation direction. While the switching dynamics are one of the most important characteristics of flagellar…

亚细胞过程 · 定量生物学 2008-11-18 Siebe B. van Albada , Sorin Tanase-Nicola , Pieter Rein ten Wolde

The bacterial flagellar motor is a highly efficient rotary machine used by many bacteria to propel themselves. It has recently been shown that at low speeds its rotation proceeds in steps [Sowa et al. (2005) Nature 437, 916--919]. Here we…

生物物理 · 物理学 2009-10-25 Thierry Mora , Howard Yu , Yoshiyuki Sowa , Ned S. Wingreen

Numerous studies have explored the link between bacterial swimming and the number of flagella, a distinguishing feature of motile multiflagellated bacteria. We revisit this open question using augmented slender-body theory simulations, in…

生物物理 · 物理学 2024-09-04 Maria Tătulea-Codrean , Eric Lauga

The bacterial flagellar motor (BFM) is a rotary molecular machine driven by the ion electrochemical potential across the cell membrane. Recent cryo-EM structures reveal a cogwheel-like architecture in which multiple stators engage a large…

生物物理 · 物理学 2026-04-02 Jiading Zhu , Yongnan Hu , Yuhai Tu , Yuansheng Cao

Many types of bacteria swim by rotating a bundle of helical filaments also called flagella. Each filament is driven by a rotary motor and a very flexible hook transmits the motor torque to the filament. We model it by discretizing…

生物物理 · 物理学 2012-01-04 Reinhard Vogel , Holger Stark

In this Supporting information we provide background information on our model of the bacterial flagellar motor. We also derive the analytical solution of our coarse-grained model of the switching dynamics and explain the hybrid stochastic…

亚细胞过程 · 定量生物学 2008-11-20 Siebe B. van Albada , Sorin Tanase-Nicola , Pieter Rein ten Wolde

The bacterial flagellar motor plays a crucial role in both bacterial locomotion and chemotaxis. Recent experiments reveal that the switching dynamics of the motor depends on the motor rotation speed, and thus the motor torque,…

生物物理 · 物理学 2013-07-26 Fan Bai , Tohru Minamino , Zhanghan Wu , Keiichi Namba , Jianhua Xing

Rotation of a single bacterial flagellar motor is powered by multiple stators tethered to the cell wall. In a "power-stroke" model the observed independence of the speed at low load on the number of stators is explained by a…

亚细胞过程 · 定量生物学 2010-08-16 Giovanni Meacci , Ganhui Lan , Yuhai Tu

We present a minimal physical model for the flagellar motor that enables bacteria to swim. Our model explains the experimentally measured torque-speed relationship of the proton-driven E. coli motor at various pH and temperature conditions.…

亚细胞过程 · 定量生物学 2009-12-11 Thierry Mora , Howard Yu , Ned S. Wingreen

Recent experiments on the bacterial flagellar motor have shown that the structure of this nanomachine, which drives locomotion in a wide range of bacterial species, is more dynamic than previously believed. Specifically, the number of…

生物物理 · 物理学 2016-08-24 Jasmine A. Nirody , Richard M. Berry , George Oster

The hydrodynamic interactions among bacterial cell bodies, flagella, and surrounding boundaries are essential for understanding bacterial motility in complex environments. In this study, we demonstrate that each slender flagellum can be…

软凝聚态物质 · 物理学 2025-01-07 Baopi Liu , Lu Chen , Ji Zhang

Many bacteria are motile by means of one or more rotating rigid helical flagella, making them the only known organism to use rotation as a means of propulsion. The rotation is supplied by the bacterial flagellar motor, a particularly…

We review the properties of biological motor proteins which move along linear filaments that are polar and periodic. The physics of the operation of such motors can be described by simple stochastic models which are coupled to a chemical…

生物物理 · 物理学 2009-10-31 Frank Julicher

Bacterial flagellar motor is one of the most complex and sophisticated nano machineries in nature. A duty ratio $D$ is a fraction of time that the stator and the rotor interact and is a fundamental property to characterize the motor but…

生物物理 · 物理学 2019-06-26 Kento Sato , Shuichi Nakamura , Seishi Kudo , Shoichi Toyabe

The cooperative binding of molecular agents onto a substrate is pervasive in living systems. To study whether a system shows cooperativity, one can rely on a fluctuation analysis of quantities such as the number of substrate-bound units and…

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