相关论文: A novel minimal in vitro system for analyzing HIV-…
A lack of understanding of human biology creates a hurdle for the development of precision medicines. To overcome this hurdle we need to better understand the potential synergy between a given investigational treatment (vs. placebo or…
The discovery of the Higgs particle at 125 GeV has put strong constraints on minimal messenger models of gauge mediation, pushing the stop masses into the multi-TeV regime. Extensions of these models with matter-messenger mixing terms have…
In clathrin-mediated endocytosis (CME), clathrin and various adaptor proteins coat a patch of the plasma membrane, which is reshaped to form a budded vesicle. Experimental studies have demonstrated that elevated membrane tension can inhibit…
Additive manufacturing enables the fabrication of complex designs while minimizing waste, but faces challenges related to defects and process anomalies. This study presents a novel multimodal Retrieval-Augmented Generation-based framework…
The $2$-cell embeddings of graphs on closed surfaces have been widely studied. It is well known that ($2$-cell) embedding a given graph $G$ on a closed orientable surface is equivalent to cyclically ordering the edges incident to each…
We investigate continuous generation of bubbles from a bath of air in viscous liquid in a confined geometry. In our original setup, bubbles are spontaneously generated by virtue of buoyancy and a gate placed in the cell: the gate acts like…
Recent work has shown that the hydrophobic protein surfaces in aqueous solution sit near a drying transition. The tendency for these surfaces to expel water from their vicinity leads to self assembly of macromolecular complexes. In this…
Being the HIV-1 Protease (HIV-1-PR) an essential enzyme in the viral life cycle, its inhibition can control AIDS. The folding of single domain proteins, like each of the monomers forming the HIV-1-PR homodimer, is controlled by local…
The evolution of galaxies depends on their interaction with the surrounding environment. Ultra-diffuse galaxies (UDGs) have been found in large numbers in clusters. We detected a few star-forming blobs in the VESTIGE survey, located at…
During pilot observations of the Virgo Environmental Survey Tracing Galaxy Evolution (VESTIGE), a blind narrow-band Halpha+[NII] imaging survey of the Virgo cluster carried out with MegaCam at the CFHT, we have observed the spiral galaxy…
We proposed a dual-template multi-cycled DNA nanomachine driven by polymerase nicking enzyme with high efficiency. The reaction system simply consists of two templates (T1, T2) and two enzymes (KF polymerase, Nb.BbvCI). The two templates…
The formation of a viral capsid -- the highly-ordered protein shell that surrounds the genome of a virus -- is the canonical example of self-assembly. The capsids of many positive-sense RNA viruses spontaneously assemble from in vitro…
Although common in nature, the self-assembly of small molecules at sold-liquid interfaces is difficult to control in artificial systems. The high mobility of dissolved small molecules limits their residence at the interface, typically…
People living with HIV on antiretroviral therapy often have undetectable virus levels by standard assays, but "latent" HIV still persists in viral reservoirs. Eliminating these reservoirs is the goal of HIV cure research. The quantitative…
$\textbf{Background:}$ High mutability of HIV is the driving force of antiretroviral drug resistance, which represents a medical care challenge. $\textbf{Method and Model Equation:}$ To detect the mutability of each gene in the HIV-1…
Droplet microfluidics are a powerful approach for hydrogel cell encapsulations. Much of the field has focused on single-cell encapsulations with pico-nanoliter droplet volumes necessary for single-cell sequencing or high-throughput…
Hollow microgels are elastic polymer shells easily realizable in experiments. Recent works have shown the emergence of buckling events in dilute hollow microgels under the effect of an added osmotic pressure. Here, we perform large-scale…
A possible minimal model of the gauge-Higgs unification based on the higher dimensional spacetime M^4 X (S^1/Z_2) and the bulk gauge symmetry SU(3)_C X SU(3)_W X U(1)_X is constructed in some details. We argue that the Weinberg angle and…
The discovery of a standard-model-like Higgs at 126 GeV and the absence of squark signals thus far at the LHC both point towards a mini-split spectrum for supersymmetry. Within standard paradigms, it is non-trivial to realize a mini-split…
Diffusion-based microfluidic gradient generators (DMGGs) are essential for various in-vitro studies due to their ability to provide a convection-free concentration gradient. However, these systems, often referred to as membrane-based DMGGs,…