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Adverse drug reaction (ADR) is widely concerned for public health issue. ADRs are one of most common causes to withdraw some drugs from market. Prescription event monitoring (PEM) is an important approach to detect the adverse drug…

机器学习 · 计算机科学 2014-09-03 Yihui Liu , Uwe Aickelin

Adverse drug reaction (ADR) is widely concerned for public health issue. ADRs are one of most common causes to withdraw some drugs from market. Prescription event monitoring (PEM) is an important approach to detect the adverse drug…

计算工程、金融与科学 · 计算机科学 2013-07-08 Yihui Liu , Uwe Aickelin

Adverse drug reactions (ADR) are widely concerning for public health issue. In this study we propose an original approach to detect ADRs using a feature matrix and feature selection. The experiments are carried out on the drug Simvastatin.…

计算工程、金融与科学 · 计算机科学 2014-09-04 Yihui Liu , Uwe Aickelin

Adverse drug reaction (ADR) is widely concerned for public health issue. In this study we propose an original approach to detect the ADRs using feature matrix and feature selection. The experiments are carried out on the drug Aspirin. Major…

计算工程、金融与科学 · 计算机科学 2014-09-03 Yihui liu , Uwe Aickelin

Adverse drug reaction (ADR) is widely concerned for public health issue. In this study we propose an original approach to detect the ADRs using feature matrix and feature selection. The experiments are carried out on the drug Simvastatin.…

计算工程、金融与科学 · 计算机科学 2013-07-05 Yihui Liu , Uwe Aickelin

In this study we propose a novel method to successfully detect the ADRs using feature matrix and feature selection. A feature matrix, which characterizes the medical events before patients take drugs or after patients take drugs, is created…

计算工程、金融与科学 · 计算机科学 2016-11-17 Yihui Liu , Uwe Aickelin

Adverse drug reactions (ADRs) are unwanted or harmful effects experienced after the administration of a certain drug or a combination of drugs, presenting a challenge for drug development and drug administration. In this paper, we present a…

计算与语言 · 计算机科学 2019-05-29 Maksim Belousov , Nikola Milosevic , William Dixon , Goran Nenadic

The electronic healthcare databases are starting to become more readily available and are thought to have excellent potential for generating adverse drug reaction signals. The Health Improvement Network (THIN) database is an electronic…

机器学习 · 计算机科学 2014-09-03 Jenna Reps , Jonathan M. Garibaldi , Uwe Aickelin , Daniele Soria , Jack Gibson , Richard Hubbard

Adverse Drug Reaction (ADR) is a significant public health concern world-wide. Numerous graph-based methods have been applied to biomedical graphs for predicting ADRs in pre-marketing phases. ADR detection in post-market surveillance is no…

机器学习 · 计算机科学 2020-04-02 Heeyoung Kwak , Minwoo Lee , Seunghyun Yoon , Jooyoung Chang , Sangmin Park , Kyomin Jung

Adverse drug reactions (ADRs) are one of the leading causes of mortality in health care. Current ADR surveillance systems are often associated with a substantial time lag before such events are officially published. On the other hand,…

信息检索 · 计算机科学 2018-02-15 Shashank Gupta , Manish Gupta , Vasudeva Varma , Sachin Pawar , Nitin Ramrakhiyani , Girish K. Palshikar

Adverse drug reaction (ADR) prediction plays a crucial role in both health care and drug discovery for reducing patient mortality and enhancing drug safety. Recently, many studies have been devoted to effectively predict the drug-ADRs…

信息检索 · 计算机科学 2023-08-08 Haoxuan Li , Taojun Hu , Zetong Xiong , Chunyuan Zheng , Fuli Feng , Xiangnan He , Xiao-Hua Zhou

Adverse drug reactions / events (ADR/ADE) have a major impact on patient health and health care costs. Detecting ADR's as early as possible and sharing them with regulators, pharma companies, and healthcare providers can prevent morbidity…

计算与语言 · 计算机科学 2022-01-07 Hasham Ul Haq , Veysel Kocaman , David Talby

With the advancements in Artificial intelligence (AI) and the accumulation of healthrelated big data, it has become increasingly feasible and commonplace to leverage machine learning technologies to analyze clinical and omics metadata to…

基因组学 · 定量生物学 2022-04-14 Attayeb Mohsen , Lokesh P. Tripathi , Kenji Mizuguchi

Adverse Drug Reactions (ADRs) are characterized within randomized clinical trials and postmarketing pharmacovigilance, but their molecular mechanism remains unknown in most cases. Aside from clinical trials, many elements of knowledge about…

Despite extensive safety assessments of drugs prior to their introduction to the market, certain adverse drug reactions (ADRs) remain undetected. The primary objective of pharmacovigilance is to identify these ADRs (i.e., signals). In…

统计方法学 · 统计学 2024-04-23 Louis Dijkstra , Tania Schink , Ronja Foraita

Automatic monitoring of adverse drug events (ADEs) or reactions (ADRs) is currently receiving significant attention from the biomedical community. In recent years, user-generated data on social media has become a valuable resource for this…

计算与语言 · 计算机科学 2023-11-21 Ilseyar Alimova , Elena Tutubalina

Social media has grown to be a crucial information source for pharmacovigilance studies where an increasing number of people post adverse reactions to medical drugs that are previously unreported. Aiming to effectively monitor various…

机器学习 · 计算机科学 2018-02-19 Shaika Chowdhury , Chenwei Zhang , Philip S. Yu

Spontaneous reporting system databases are key resources for post-marketing surveillance, providing real-world evidence (RWE) on the adverse events (AEs) of regulated drugs or other medical products. Various statistical methods have been…

统计方法学 · 统计学 2026-03-24 Xin-Wei Huang , Saptarshi Chakraborty

Adverse drug events (ADEs) are unexpected incidents caused by the administration of a drug or medication. To identify and extract these events, we require information about not just the drug itself but attributes describing the drug (e.g.,…

计算与语言 · 计算机科学 2021-04-23 Darshini Mahendran , Bridget T. McInnes

Adverse drug reactions (ADRs) induced from high-order drug-drug interactions (DDIs) due to polypharmacy represent a significant public health problem. In this paper, we formally formulate the to-avoid and safe (with respect to ADRs) drug…

信息检索 · 计算机科学 2018-03-09 Wen-Hao Chiang , Li Shen , Lang Li , Xia Ning
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