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High angular resolution diffusion imaging (HARDI) is a type of diffusion magnetic resonance imaging (dMRI) that measures diffusion signals on a sphere in q-space. It has been widely used in data acquisition for human brain structural…

应用统计 · 统计学 2021-11-12 William Consagra , Arun Venkataraman , Zhengwu Zhang

Development of successful therapies for neurological disorders depends on our ability to diagnose and monitor the progression of underlying pathologies at the cellular level. Physics and physiology limit the resolution of human MRI to…

生物物理 · 物理学 2016-09-30 Jelle Veraart , Els Fieremans , Dmitry S. Novikov

Statistical analysis of magnetic resonance imaging (MRI) can help radiologists to detect pathologies that are otherwise likely to be missed. Deep learning (DL) has shown promise in modeling complex spatial data for brain anomaly detection.…

计算机视觉与模式识别 · 计算机科学 2020-11-26 Victor Saase , Holger Wenz , Thomas Ganslandt , Christoph Groden , Máté E. Maros

Diffusion MRI is a powerful tool that serves as a bridge between brain microstructure and cognition. Recent advancements in cognitive neuroscience have highlighted the persistent challenge of understanding how individual differences in…

神经元与认知 · 定量生物学 2024-09-25 Gabriela Gómez Jiménez , Demian Wassermann

Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which pathological changes begin many years before the onset of clinical symptoms, making early detection essential for timely intervention. T1-weighted (T1w) Magnetic…

计算机视觉与模式识别 · 计算机科学 2026-01-21 Jason Qiu

The structure of grey matter has long been a key focus in neuroscience, as cell morphology varies by type and can be affected by neurological conditions. Understanding these variations is essential for studying brain function and disease.…

生物物理 · 物理学 2025-08-27 Charlie Aird-Rossiter , Hui Zhang , Daniel C. Alexander , Derek K. Jones , Marco Palombo

Magnetic resonance imaging (MRI) is the method of choice for noninvasive studies of micrometer-scale structures in biological tissues via their effects on the time/frequency-dependent ("restricted") and anisotropic self-diffusion of water.…

We review, systematize and discuss models of diffusion in neuronal tissue, by putting them into an overarching physical context of coarse-graining over an increasing diffusion length scale. From this perspective, we view research on…

生物物理 · 物理学 2018-04-20 Dmitry S. Novikov , Els Fieremans , Sune N. Jespersen , Valerij G. Kiselev

Tissue microstructure has significance as a biomarker, however its accurate inference with diffusion magnetic resonance (MR) is still an open problem. With few exceptions, diffusion weighted (DW) MR models either process diffusion MR data…

医学物理 · 物理学 2019-08-20 Alpay Özcan

Mild Traumatic Brain Injury (mTBI) is a significant public health problem. The most troubling symptoms after mTBI are cognitive complaints. Studies show measurable differences between patients with mTBI and healthy controls with respect to…

图像与视频处理 · 电气工程与系统科学 2019-11-12 Tongda Xu , Xiyan Cai , Yao Wang , Xiuyuan Wang , Sohae Chung , Els Fieremans , Joseph Rath , Steven Flanagan , Yvonne W Lui

Diffusion-weighted imaging (DWI) in the female breast is a magnetic resonance imaging (MRI) technique, which may potentially replace or effectively complement both x-ray mammography and contrast-enhanced MR mammography. To further improve…

T2-weighted magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) are essential components for cervical cancer diagnosis. However, combining these channels for training deep learning models are challenging due to…

图像与视频处理 · 电气工程与系统科学 2023-06-21 Reza Kalantar , Sebastian Curcean , Jessica M Winfield , Gigin Lin , Christina Messiou , Matthew D Blackledge , Dow-Mu Koh

Diffusion magnetic resonance imaging (dMRI) tractography is an advanced imaging technique that enables in vivo mapping of the brain's white matter connections at macro scale. Over the last two decades, the study of brain connectivity using…

We propose a novel approach to denoising diffusion magnetic resonance images (dMRI) using convolutional neural networks, that exploits the benefits of data acquired at multiple b-values to offset the need for many redundant observations.…

图像与视频处理 · 电气工程与系统科学 2024-10-23 Jakub Jurek , Andrzej Materka , Kamil Ludwisiak , Agata Majos , Filip Szczepankiewicz

Deep learning has been successful in predicting neurodegenerative disorders, such as Alzheimer's disease, from magnetic resonance imaging (MRI). Combining multiple imaging modalities, such as T1-weighted (T1) and diffusion-weighted imaging…

Diffusion magnetic resonance imaging (dMRI) enables non-invasive investigation of tissue microstructure. The Standard Model (SM) of white matter aims to disentangle dMRI signal contributions from intra- and extra-axonal water compartments.…

图像与视频处理 · 电气工程与系统科学 2026-04-15 Tom Hendriks , Gerrit Arends , Edwin Versteeg , Anna Vilanova , Maxime Chamberland , Chantal M. W. Tax

Diffusion magnetic resonance imaging (dMRI) plays a vital role in both clinical diagnostics and neuroscience research. However, its inherently low signal-to-noise ratio (SNR), especially under high diffusion weighting, significantly…

定量方法 · 定量生物学 2026-02-27 Jine Xie , Zhicheng Zhang , Yunwei Chen , Yanqiu Feng , Xinyuan Zhang

Purpose: In diffusion MRI (dMRI), the volumetric and bundle analyses of whole-brain tissue microstructure and connectivity can be severely impeded by an incomplete field-of-view (FOV). This work aims to develop a method for imputing the…

Quantitative information on tumor heterogeneity and cell load could assist in designing effective and refined personalized treatment strategies. It was recently shown by us that such information can be inferred from the diffusion parameter…

图像与视频处理 · 电气工程与系统科学 2021-03-11 Yi Yin , Kai Breuhahn , Hans-Ulrich Kauczor , Oliver Sedlaczek , Irene E. Vignon-Clementel , Dirk Drasdo

Axon radius is a potential biomarker for brain diseases and a crucial tissue microstructure parameter that determines the speed of action potentials. Diffusion MRI (dMRI) allows non-invasive estimation of axon radius, but accurately…