相关论文: Rate in Template-directed Polymer Synthesis

Machine translation systems are expected to cope with various types of constraints in many practical scenarios. While neural machine translation (NMT) has achieved strong performance in unconstrained cases, it is non-trivial to impose…

Templated copying is the central operation by which biology produces complex molecules. Cells copy sequence information from DNA to RNA and on into proteins, which are the molecules responsible for the function and regulation of cellular…

Information has an entropic character which can be analyzed within the Statistical Theory in molecular systems. R. Landauer and C.H. Bennett showed that a logical copy can be carried out in the limit of no dissipation if the computation is…

A kinetic theory is developed for exonuclease-deficient DNA polymerases, based on the experimental observation that the rates depend not only on the newly incorporated nucleotide, but also on the previous one, leading to the growth of…

Dynamical system models (including RNNs) often lack the ability to adapt the sequence generation or prediction to a given context, limiting their real-world application. In this paper we show that hierarchical multi-task dynamical systems…

Interpreting the data from radio detectors for extensive air showers typically relies on Monte-Carlo based simulation codes, which, despite their accuracy are computationally expensive and present bottlenecks for analyses. To address this…

Score-based generative models (SGMs) have recently emerged as a promising class of generative models. The key idea is to produce high-quality images by recurrently adding Gaussian noises and gradients to a Gaussian sample until converging…

A DNA polymerase (DNAP) replicates a template DNA strand. It also exploits the template as the track for its own motor-like mechanical movement. In the polymerase mode it elongates the nascent DNA by one nucleotide in each step. But,…

Natural Language Processing (NLP) has undergone transformative changes with the advent of deep learning methodologies. One challenge persistently confronting researchers is the scarcity of high-quality, annotated datasets that drive these…

Biphilic microdome arrays are ubiquitous in nature, but their synthetic counterparts have been scarce. To bridge that gap, we leverage condensed droplet polymerization (CDP) to enable their template-free synthesis. During CDP, monomer…

X-ray Thomson scattering (XRTS) constitutes an essential technique for diagnosing material properties under extreme conditions, such as high pressures and intense laser heating. Time-dependent density functional theory (TDDFT) is one of the…

Denoising diffusion probabilistic models (DDPMs) have recently achieved leading performances in many generative tasks. However, the inherited iterative sampling process costs hindered their applications to speech synthesis. This paper…

Experimental evidences show that in gene transcription, RNA polymerase has the possibility to be stalled at certain position of the transcription template. This may be due to the template damage, or protein barriers. Once stalled,…

System Level Synthesis (SLS) allows us to construct internally stabilizing controllers for large-scale systems. However, solving large-scale SLS problems is computationally expensive and the state-of-the-art methods consider only state…

DNA synthesis is considered as one of the most expensive components in current DNA storage systems. In this paper, focusing on a common synthesis machine, which generates multiple DNA strands in parallel following a fixed supersequence,we…

Template-based synthesis, also known as sketching, is a localized approach to program synthesis in which the programmer provides not only a specification, but also a high-level ``sketch'' of the program. The sketch is basically a partial…

Diffusion and flow matching models have achieved remarkable success in text-to-image generation. However, these models typically rely on the predetermined denoising schedules for all prompts. The multi-step reverse diffusion process can be…

Living systems produce "persistent" copies of information-carrying polymers, in which template and copy sequences remain correlated after physically decoupling. We identify a general measure of the thermodynamic efficiency with which these…

With the rapid development of machine learning applications on time-series data, accurately assessing the value of training samples has become essential for data selection, noise detection, and model optimization. However, traditional data…

We introduce RapFlow-TTS, a rapid and high-fidelity TTS acoustic model that leverages velocity consistency constraints in flow matching (FM) training. Although ordinary differential equation (ODE)-based TTS generation achieves…