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Transcranial photobiomodulation is an optical method for non-invasive brain stimulation. The method projects red and near-infrared light through the scalp within 600-1100 nm and low energy within the 1-20 J/cm2 range. Recent studies have…

数值分析 · 数学 2022-12-12 Faezeh Ibrahimi , Mehdi Delrobaei

Studies have shown that in noisy acoustic environments, providing binaural signals to the user of an assistive listening device may improve speech intelligibility and spatial awareness. This paper presents a binaural speech enhancement…

音频与语音处理 · 电气工程与系统科学 2024-03-11 Vikas Tokala , Eric Grinstein , Mike Brookes , Simon Doclo , Jesper Jensen , Patrick A. Naylor

Noninvasive brain stimulation can activate neurons in the brain but requires power electronics with exceptionally high power in the mega-volt-ampere and high frequencies in the kilohertz range. Whereas oscillator circuits offered only one…

医学物理 · 物理学 2025-03-11 Jinshui Zhang , Angel Peterchev , Stefan Goetz

Intracellular recordings of neuronal membrane potential are a central tool in neurophysiology. In many situations, especially in vivo, the traditional limitation of such recordings is the high electrode resistance, which may cause…

神经元与认知 · 定量生物学 2007-11-15 R. Brette , Z. Piwkowska , M. Rudolph-Lilith , T. Bal , A. Destexhe

The electrical properties of extracellular space around neurons are important to understand the genesis of extracellular potentials, as well as for localizing neuronal activity from extracellular recordings. However, the exact nature of…

For decades, focal non-invasive neuromodulation of deep brain regions has not been possible because of the steep depth-focality trade-off of conventional non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic…

神经元与认知 · 定量生物学 2025-12-17 Pierre Vassiliadis , Elena Beanato , Maximilian J. Wessel , Friedhelm C. Hummel

Intrathecal (IT) injection is an effective way to deliver drugs to the brain bypassing the blood-brain barrier. To evaluate and optimize IT drug delivery, it is necessary to understand the cerebrospinal fluid (CSF) dynamics in the central…

医学物理 · 物理学 2025-11-12 Zhuogen Li , Keyu Feng , Hector Gomez

Transcranial magnetic stimulation (TMS) is a technique for noninvasively stimulating a brain area for therapeutic, rehabilitation treatments and neuroscience research. Despite our understanding of the physical principles and experimental…

神经元与认知 · 定量生物学 2020-12-30 Jose Gomez-Tames , Ilkka Laakso , Akimasa Hirata

Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), a new imaging method…

Slow oscillations are electrical potential oscillations with a spectral peak frequency of $\sim$0.8 Hz, and hallmark the electroencephalogram during slow-wave sleep. Recent studies have indicated a causal contribution of slow oscillations…

神经元与认知 · 定量生物学 2014-07-31 Hong-Viet V. Ngo , Jens Christian Claussen , Jan Born , Matthias Mölle

Animal cells in tissues are supported by biopolymer matrices, which typically exhibit highly nonlinear mechanical properties. While the linear elasticity of the matrix can significantly impact cell mechanics and functionality, it remains…

Cyborg in the brain-machine interface field has attracted more attention in recent years. To control a creature via a machine called cyborg method, three stages are considerable: stimulation of neurons, neural response, and the behavioral…

生物物理 · 物理学 2019-05-01 Mohammad Jamali , Yousef Jamali , Mehdi Golshani

Stiff and dense fibrin networks in chronic blood clots impede drug penetration and distribution into the clot core, limiting the efficacy of thrombolytic therapies. Acoustic cavitation of microbubbles is a promising strategy to enhance drug…

软凝聚态物质 · 物理学 2026-05-29 Aarushi Bhargava , Gaurav Gardi , Metin Sitti

The effect of AC electric fields on the elasticity of supported lipid bilayers has been investigated at the microscopic level using grazing incidence synchrotron x-ray scattering. A strong decrease in the membrane tension up to 1mN/m and a…

软凝聚态物质 · 物理学 2016-06-08 Arnaud Hemmerle , Thierry Charitat , Giovanna Fragneto , Jean Daillant

Electrical signals play the primary role in rapid communication among organs, tissues and cells in biosystems. We have analyzed and discussed three phenomena of electrical communication in biosystems, including direction-changing movement…

生物物理 · 物理学 2017-08-11 Jingjing Xu , Fan Yang , Danhong Han , Shengyong Xu

Stimulated by ongoing discussions about the relevance of mechanical motion in the propagation of nerve signals capillary waves of water-based electrolytes in elastic tubular systems are considered as an essential ingredient. Their…

生物物理 · 物理学 2019-09-27 Jörg P. Kotthaus

This study presents the first observation of shear wave induced remotely within soft tissues. It was performed through the combination of a transcranial magnetic stimulation device and a permanent magnet. A physical model based on Maxwell…

We present a novel methodology to enable control of a neuromorphic circuit in close analogy with the physiological neuromodulation of a single neuron. The methodology is general in that it only relies on a parallel interconnection of…

神经元与认知 · 定量生物学 2020-11-19 Luka Ribar , Rodolphe Sepulchre

Single-cell studies often show significant phenotypic variability due to the stochastic nature of intra-cellular biochemical reactions. When the numbers of molecules, e.g., transcription factors and regulatory enzymes, are in low abundance,…

定量方法 · 定量生物学 2015-06-17 Kyung Hyuk Kim , Hong Qian , Herbert M. Sauro

Recent advances in associative memory design through structured pattern sets and graph-based inference algorithms have allowed reliable learning and recall of an exponential number of patterns. Although these designs correct external errors…

神经与进化计算 · 计算机科学 2014-03-14 Amin Karbasi , Amir Hesam Salavati , Amin Shokrollahi , Lav R. Varshney