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We discover a new type of nonequilibrium phase transition in a model of chromatin dynamics, which accounts for the coherent motions that have been observed in experiment. The coherent motion is due to the long-range cooperation of molecular…

软凝聚态物质 · 物理学 2023-07-27 Iraj Eshghi , Alexanda Zidovska , Alexander Y. Grosberg

While mechanobiology has demonstrated that precise control over mechanical properties at the whole-cell level is crucial for many biological functions, comparatively little attention has been paid to the intracellular mechanical properties.…

亚细胞过程 · 定量生物学 2025-01-27 Mohammad Amin Eskandari , Jannis Fischer , Noémie Veyret , Dorian Marx , Timo Betz

Based only on classical Hamiltonian dynamics, we prove the maximum work principle in a system where macroscopic dynamical degrees of freedom are intrinsically coupled to microscopic degrees of freedom. Unlike recent identities between…

统计力学 · 物理学 2015-05-26 Christian Maes , Hal Tasaki

Colloidal motors without moving parts can be propelled by self-diffusiophoresis, coupling molecular concentration gradients generated by surface chemical reactions to the velocity slip between solid Janus particles and the surrounding fluid…

统计力学 · 物理学 2021-02-08 Pierre Gaspard , Raymond Kapral

Understanding and simulating how a quantum system interacts and exchanges information or energy with its surroundings is a ubiquitous problem, one which must be carefully addressed in order to establish a coherent framework to describe the…

量子物理 · 物理学 2021-05-25 Steve Campbell , Bassano Vacchini

Quantifying the outcomes of cells collisions is a crucial step in building the foundations of a kinetic theory of living matter. Here, we develop a mechanical theory of such collisions by first representing individual cells as extended…

生物物理 · 物理学 2019-12-11 Pierre Recho , Thibaut Putelat , Lev Truskinovsky

Quantum cycles in established heat engines can be modeled with various quantum systems as working substances. For example, a heat engine can be modeled with an infinite potential well as the working substance to determine the efficiency and…

量子物理 · 物理学 2021-04-15 Pritam Chattopadhyay , Ayan Mitra , Goutam Paul , Vasilios Zarikas

Several recent theories address the efficiency of a macroscopic thermodynamic motor at maximum power and question the so-called "Curzon-Ahlborn (CA) efficiency." Considering the entropy exchanges and productions in an n-sources motor, we…

统计力学 · 物理学 2015-06-03 M. Moreau , B. Gaveau , L. S. Schulman

In intracellular transports, motor proteins transport macromolecules as cargos to desired locations by moving on biopolymers such as microtubules. Recent experiments suggest that cargos that can associate motor proteins during their…

生物物理 · 物理学 2023-07-04 Sutapa Mukherji , Dhruvi K. Patel

This paper deals with the modeling and mathematical analysis of vehicular traffic phenomena according to a kinetic theory approach, where the microscopic state of vehicles is described by: (i) position, (ii) velocity, as a continuous…

偏微分方程分析 · 数学 2021-03-26 J. Calvo , J. Nieto , M. Zagour

We study the effect of a coupling between two motor domains in highly-processive motor protein complexes. A simple stochastic discrete model, in which the two parts of the protein molecule interact through some energy potential, is…

软凝聚态物质 · 物理学 2009-11-11 Evgeny B. Stukalin , Hubert Phillips , Anatoly B. Kolomeisky

The traffic of molecular motors which interact through mutual exclusion is studied theoretically for half-open tube-like compartments. These half-open tubes mimic the shapes of axons. The mutual exclusion leads to traffic jams or density…

统计力学 · 物理学 2007-05-23 Melanie J. I. Muller , Stefan Klumpp , Reinhard Lipowsky

Dynamics of molecular motors that move along linear lattices and interact with them via reversible destruction of specific lattice bonds is investigated theoretically by analyzing exactly solvable discrete-state ``burnt-bridge'' models.…

软凝聚态物质 · 物理学 2009-11-13 Max N. Artyomov , Alexander Yu. Morozov , Anatoly B. Kolomeisky

We present a generic coarse-grained model to describe molecular motors acting on polymer substrates, mimicking, for example, RNA polymerase on DNA or kinesin on microtubules. The polymer is modeled as a connected chain of beads; motors are…

软凝聚态物质 · 物理学 2020-10-14 M. Foglino , E. Locatelli , C. A. Brackley , D. Michieletto , C. Likos , D. Marenduzzo

We show that transport in the presence of entropic barriers exhibits peculiar characteristics which makes it distinctly different from that occurring through energy barriers. The constrained dynamics yields a scaling regime for the particle…

统计力学 · 物理学 2009-11-11 D. Reguera , G. Schmid , P. S. Burada , J. M. Rubí , P. Hänggi

Improved understanding of molecular systems has only emphasised the sophistication of networks within the cell. Simultaneously, the advance of nucleic acid nanotechnology, a platform within which reactions can be exquisitely controlled, has…

分子网络 · 定量生物学 2017-10-03 Thomas E. Ouldridge

Keratin are among the most abundant proteins in epithelial cells. Functions of the keratin network in cells are shaped by their dynamical organization. Using a collection of experimentally-driven mathematical models, different hypotheses…

亚细胞过程 · 定量生物学 2015-08-19 Stephanie Portet , Anotida Madzvamuse , Andy Chung , Rudolf E. Leube , Reinhard Windoffer

The energetics and efficiency of a linear molecular motor model proposed by Mogilner et al. (Phys. Lett. 237, 297 (1998)) is analyzed from an analytical point of view. The model which is based on protein friction with a track is described…

统计力学 · 物理学 2014-10-07 Hans C. Fogedby , Axel Svane

Recent experiments reveal both passive subdiffusion of various nanoparticles and anomalous active transport of such particles by molecular motors in the molecularly crowded environment of living biological cells. Passive and active…

生物物理 · 物理学 2014-03-24 Igor Goychuk , Vasyl O. Kharchenko , R. Metzler

In this note, we analyze the relationships that should govern the use of thermodynamics in fluid mechanics in a way that we believe is understandable to mathematicians. We also aim to better define the reasons why mechanics and…

经典物理 · 物理学 2026-02-26 Henri Gouin