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Inferring the mechanical properties of soft tissues from measured deformations is a fundamental challenge in elastography. A rarely examined assumption underlying existing approaches is that the assumed constitutive law correctly describes…

机器学习 · 统计学 2026-04-15 Vincent C. Scholz , P. S. Koutsourelakis

Accurate acoustic simulations of enclosed spaces require precise boundary conditions, typically expressed through surface impedances for wave-based methods. Conventional measurement techniques often rely on simplifying assumptions about the…

声音 · 计算机科学 2026-04-09 Jonas M. Schmid , Johannes D. Schmid , Martin Eser , Steffen Marburg

Inference of fields defined in space and time from observational data is a core discipline in many scientific areas. This work approaches the problem in a Bayesian framework. The proposed method is based on statistically homogeneous random…

数据分析、统计与概率 · 物理学 2021-05-05 Philipp Frank , Reimar Leike , Torsten A. Enßlin

Inverse analysis, such as model calibration, often suffers from a lack of informative data in complex real-world scenarios. The standard remedy, designing new experimental setups, is often costly and time-consuming, while readily available…

计算工程、金融与科学 · 计算机科学 2026-01-16 Lea J. Haeusel , Jonas Nitzler , Lea J. Köglmeier , Wolfgang A. Wall

A distinguishing feature of a multicellular living system is that it operates at various scales, from the intracellular to organismal. Very little is known at present on how tissue level properties are related to cell and subcellular…

生物物理 · 物理学 2007-06-26 Elijah Flenner , Francoise Marga , Adrian Neagu , Ioan Kosztin , Gabor Forgacs

To express the capillary stress in the diffuse interface method, there are two different formulations in the literature: one formulation is proportional to the density and the other is to the density gradient. Confusingly, these two…

软凝聚态物质 · 物理学 2025-06-26 Takeshi Omori

In the last decades, the interest to understand the connection between brain and body has grown notably. For example, in psychoneuroimmunology many studies associate stress, arising from many different sources and situations, to changes in…

定量方法 · 定量生物学 2022-07-27 Maria Elena Gonzalez Herrero , Christian Kuehn

Many immersed boundary methods solve for surface stresses that impose the velocity boundary conditions on an immersed body. These surface stresses may contain spurious oscillations that make them ill-suited for representing the physical…

流体动力学 · 物理学 2016-07-20 Andres Goza , Sebastian Liska , Benjamin Morley , Tim Colonius

In computational engineering, ensuring the integrity and safety of structures in fields such as aerospace and civil engineering relies on accurate stress prediction. However, analytical methods are limited to simple test cases, and…

计算工程、金融与科学 · 计算机科学 2025-10-31 Fabian Key , Lukas Freinberger

We present an approach for the data-driven modeling of nonlinear viscoelastic materials at small strains which is based on physics-augmented neural networks (NNs) and requires only stress and strain paths for training. The model is built on…

计算工程、金融与科学 · 计算机科学 2024-01-26 Max Rosenkranz , Karl A. Kalina , Jörg Brummund , WaiChing Sun , Markus Kästner

Pressure ulcers are a severe disease affecting patients that are bedridden or in a wheelchair bound for long periods of time. These wounds can develop in the deep layers of the skin of specific parts of the body, mostly on heels or sacrum,…

Methods utilizing instrumental variables have been a fundamental statistical approach to estimation in the presence of unmeasured confounding, usually occurring in non-randomized observational data common to fields such as economics and…

统计方法学 · 统计学 2022-10-06 Charles Spanbauer , Wei Pan

Affect recognition aims to detect a person's affective state based on observables, with the goal to e.g. provide reasoning for decision making or support mental wellbeing. Recently, besides approaches based on audio, visual or text…

人机交互 · 计算机科学 2018-11-22 Philip Schmidt , Attila Reiss , Robert Duerichen , Kristof Van Laerhoven

In dense biological tissues, cell types performing different roles remain segregated by maintaining sharp interfaces. To better understand the mechanisms for such sharp compartmentalization, we study the effect of an imposed heterotypic…

软凝聚态物质 · 物理学 2021-10-27 Preeti Sahu , J. M. Schwarz , M. Lisa Manning

Qualitative models provide crucial instruments for modelling complex biological systems. While advances in automated reasoning and symbolic encodings have enabled rigorous inference of these models from data, the process remains highly…

分子网络 · 定量生物学 2026-05-14 Ondřej Huvar , Nikola Beneš , Martin Jonáš , David Šafránek , Samuel Pastva

This study presents a novel, versatile traction force microscopy framework for quantifying three-dimensional (3D) interfacial forces during bio-adhesion by integrating in situ stereo digital image correlation with finite element (FE)…

仪器与探测器 · 物理学 2026-01-09 Yingwei Hou , Fusheng Wang , Tao Liu

Adherent biological cells generate traction forces on a substrate that play a central role for migration, mechanosensing, differentiation, and collective behavior. The established method for quantifying this cell-substrate interaction is…

细胞行为 · 定量生物学 2020-05-05 Yunfei Huang , Gerhard Gompper , Benedikt Sabass

We review studies on tissue transplantation experiments for various species: one piece of the donor tissue is excised and transplanted into a slit in the host tissue, then observe the behavior of this grafted tissue. Although we have known…

定量方法 · 定量生物学 2022-11-02 Yue Wang , Boyu Zhang , Jérémie Kropp , Nadya Morozova

We develop a novel data-driven approach to the inverse problem of classical statistical mechanics: given experimental data on the collective motion of a classical many-body system, how does one characterise the free energy landscape of that…

统计力学 · 物理学 2022-03-01 Peter Yatsyshin , Serafim Kalliadasis , Andrew B. Duncan

Model-free data-driven computational mechanics replaces phenomenological constitutive functions by numerical simulations based on data sets of representative samples in stress-strain space. The distance of strain and stress pairs from the…

计算工程、金融与科学 · 计算机科学 2021-11-29 Kerem Ciftci , Klaus Hackl