相关论文: Modelling the ATP production in mitochondria
F$_\mathrm{o}$F$_1$-ATP synthase is a factory for synthesizing ATP in virtually all cells. Its core machinery is the subcomplex F$_1$-motor (F$_1$-ATPase) and performs the reversible mechanochemical coupling. Isolated F$_1$-motor hydrolyzes…
The problem of estimating entropy production from incomplete information in stochastic thermodynamics is essential for theory and experiments. Whereas a considerable amount of work has been done on this topic, arguably, most of it is…
Novel mechanisms of defect annealing in solids are discussed, which are based on the large amplitude anharmonic lattice vibrations, a.k.a. intrinsic localized modes or discrete breathers (DBs). A model for amplification of defect annealing…
We derive and solve kinetic equations for leptogenesis within the Closed Time Path (CTP) formalism. It is particularly emphasised how the procedure of real intermediate state subtraction familiar from the Boltzmann approach is realised…
In this study, through phenomenological comparison of the velocity-force data of processive motor proteins, including conventional kinesin, cytoplasmic dynein and myosin V, we found that, the ratio between motor velocities of two different…
The phase space contraction and the entropy production rates of Hamiltonian systems in an external field, thermostatted to obtain a stationary state are considered. While for stationary states with a constant kinetic energy the two rates…
Static disorder plays a crucial role in the electronic dynamics and spectroscopy of complex molecular systems. Traditionally, obtaining observables averaged over static disorder requires thousands of realizations via direct sampling of the…
In the high persistence regime of non-inertial active Brownian particles (ABP), polarization becomes a relevant dynamical field. Based on a recently proposed kinetic description for ABP, we derive Navier-Stokes-like equations for the…
Purpose: Arterial spin labeling (ASL) perfusion imaging indicates direct and absolute measurement of cerebral blood flow (CBF). Arterial transit time (ATT) is a related physiological parameter reflecting the duration for the labeled spins…
In this work, we study in detail the distribution of stochastic forces generated by the molecular motors activity, in the actin cortex of pre-muscular cells. By combining active and passive rheology experiments, performed on the same…
Certain thermal non-equilibrium situations, outside of the astrophysical realm, suggest that entropy production extrema, instead of entropy extrema, are related to stationary states. In an effort to better understand the evolution of…
In living cells, oscillation of the concentration of cytosolic Ca2+ is an important and pervasive signal for the intercellular and intracellular information conduction. To generate the oscillation, the hydrolysis of ATP is always needed.…
Entropy production during the process of thermal phase-separation of multiphase flows is investigated by means of a discrete Boltzmann kinetic model. The entropy production rate is found to increase during the spinodal decomposition stage…
The proton motive force (PMF) across the inner mitochondrial membrane delivers approximately 0.2 eV of energy per proton, powering the FoF1-ATP synthase molecular motor. Here, we provide a detailed accounting of how this energy is utilized:…
Optical tracking in vivo experiments reveal that diffusion of particles in biological cells is strongly enhanced in the presence of ATP and the experimental data for animal cells could previously be reproduced within a phenomenological…
Optical microscopy provides rich spatio-temporal information characterizing in vivo molecular motion. However, effective forces and other parameters used to summarize molecular motion change over time in live cells due to latent state…
The biotransport of the intravascular nanoparticle (NP) is influenced by both the complex cellular flow environment and the NP characteristics. Being able to computationally simulate such intricate transport phenomenon with high efficiency…
Many cell types exhibit oscillatory activity, such as repetitive action potential firing due to the Hodgkin-Huxley dynamics of ion channels in the cell membrane or reveal intracellular inositol triphosphate (IP$_3$) mediated calcium…
Using Brownian dynamics simulations, the motion of active Brownian particles (ABPs) in the presence of fuel (or 'food') sources is studied. It is an established fact that within confined stationary systems, the activity of ABPs generates…
ATPases cyclically convert chemical energy in the form of ATP gradients into directed motion inside cells. To function, ATPases rely on allosteric communication between at least two binding sites, an internal signaling mechanism that is not…