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Environmental stress, such as oxidative or heat stress, induces the activation of the Heat Shock Response (HSR) which leads to an increase in the heat shock proteins (HSPs) level. These HSPs act as molecular chaperones to maintain…
Production of heat shock proteins are induced when a living cell is exposed to a rise in temperature. The heat shock response of protein DnaK synthesis in E.coli for temperature shifts from temperature T to T plus 7 degrees, respectively to…
In biology, homeostasis is the process of maintaining a stable internal environment, which is crucial for optimal functioning of organisms. One of the key homeostatic mechanisms is thermoregulation that allows the organism to maintain its…
The transcriptional regulation of gene expression is orchestrated by complex networks of interacting genes. Increasing evidence indicates that these transcriptional regulatory networks (TRNs) in bacteria have an inherently hierarchical…
This is initial study of a gene signatures responsible for adapting microscopic life to the life in extreme Earth environments. We present a results on ID of the clusters of COGs common to several hyperthermophiles and exclusion of those…
Despite the spontaneity of some in vitro protein folding reactions, native folding in vivo often requires the participation of barrel-shaped multimeric complexes known as chaperonins. Although it has long been known that chaperonin…
Aging in Caenorhabditis elegans is controlled, in part, by the insulin-like signaling and heat shock response pathways. Following thermal stress, expression levels of small heat shock protein 16.2 show a spatial patterning across the 20…
Unstructured proteins can modulate cellular responses to environmental conditions by undergoing coil-globule transitions and phase separation. However, the molecular mechanisms of these phenomena still need to be fully understood. Here, we…
To fathom the mechanism of high-temperature ($T_{\rm c}$) superconductivity, the dynamical vertex approximation (D$\Gamma$A) is evoked for the two-dimensional repulsive Hubbard model. After showing that our results well reproduce the…
Type 1 fimbriae mediate adhesion of uropathogenic Escherichia coli (UPEC) to host cells. It has been hypothesized that fimbriae can, by their ability to uncoil under exposure to force, reduce fluid shear stress on the adhesin-receptor…
Previous kinetic models had assumed that the reaction medium was reacting at random and without a turnover associated to thermodynamics exchanges, with a rigid active site on the enzyme. The experimental studies show that coupling factor 1…
Chaperonins are biological nanomachines that help newly translated proteins to fold by rescuing them from kinetically trapped misfolded states. Protein folding assistance by the chaperonin machinery is obligatory in vivo for a subset of…
Network analysis became a powerful tool in recent years. Heat shock is a well-characterized model of cellular dynamics. S. cerevisiae is an appropriate model organism, since both its protein-protein interaction network (interactome) and…
We calculate corrections to the BCS gap equation caused by the interaction of electrons with the collective phase and amplitude modes in the superconducting state. This feedback reduces the BCS gap parameter, $\Delta$, and leaves the…
This report formulates a minimal model based on a control theoretic framework to best describe the dynamics of perfect adaptation shown by the hyper osmotic shock response system in yeast. Using principles from adaptive control and…
In a pioneering study experimental evidence was sought of thermosynthesis, a theoretical biological mechanism for free energy gain from thermal cycling that has been invoked as energy source for the origin of life. A PCR machine applied…
Under dehydration conditions, amphipathic Late Embryogenesis Abundant (LEA) proteins fold spontaneously from a random conformation into alpha-helical structures and this transition is promoted by the presence of membranes. To gain insight…
Chaperone protein - the most disordered among all protein groups - help RNAs fold into their functional structure by destabilizing misfolded configurations or stabilizing the functional ones. But disentangling the mechanism underlying RNA…
The superconducting transition temperature Tc has earlier been correlated with coherence length and effective mass for a series of heavy Fermion (HF) materials at atmospheric pressure. Here, a further physical property, the dc electrical…
The phenomenon of the deconfinement -- the spectacular drop of the colorelectric string tension at the critical temperature $T_c$ -- is studied within the method of field correlators (FCM) taking into account directly the contribution of…