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In systems of coupled oscillators, the effects of complex signaling can be captured by time delays and phase shifts. Here, we show how time delays and phase shifts lead to different oscillator dynamics and how synchronization rates can be…

适应与自组织系统 · 物理学 2018-03-30 David J. Jörg , Luis G. Morelli , Saúl Ares , Frank Jülicher

Systems of mobile physical entities exchanging information with their neighborhood can be found in many different situations. The understanding of their emergent cooperative behaviour has become an important issue across disciplines,…

软凝聚态物质 · 物理学 2017-03-15 Demian Levis , Ignacio Pagonabarraga , Albert Diaz-Guilera

Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression have recently been studied intensively…

生物物理 · 物理学 2015-04-02 A. -K. Gustavsson , C. B. Adiels , B. Mehlig , M. Goksör

We analyze the emergence of synchronization in a population of moving integrate-and-fire oscillators. Oscillators, while moving on a plane, interact with their nearest neighbor upon firing time. We discover a non-monotonic dependence of the…

适应与自组织系统 · 物理学 2013-12-06 Luce Prignano , Oleguer Sagarra , Albert Díaz-Guilera

Metabolic oscillations in single cells underlie the mechanisms behind cell synchronization and cell-cell communication. For example, glycolytic oscillations mediated by biochemical communication between cells may synchronize the pulsatile…

Collective oscillation of cells in a population has been reported under diverse biological contexts and with vastly different molecular constructs. Could there be common principles similar to those that govern spontaneous oscillation in…

细胞行为 · 定量生物学 2019-07-08 Shou-Wen Wang , Lei-Han Tang

The combination of protrusions and retractions in the movement of polarized cells leads to understand the effect of possible synchronisation between the two ends of the cells. This synchronisation, in turn, could lead to different dynamics…

细胞行为 · 定量生物学 2021-09-21 Gissell Estrada-Rodriguez , Benoit Perthame

Synchronization plays a crucial role in the dynamics of living organisms, from fireflies flashing in unison to pacemaker cells that jointly generate heartbeats. Uncovering the mechanism behind these phenomena requires an understanding of…

适应与自组织系统 · 物理学 2024-05-16 Aleksandre Japaridze , Victor Struijk , Kushal Swamy , Irek Roslon , Oriel Shoshani , Cees Dekker , Farbod Alijani

The migration of cells is relevant for processes such as morphogenesis, wound healing, and invasion of cancer cells. In order to move, single cells deform cyclically. However, it is not understood how these shape oscillations influence…

生物物理 · 物理学 2019-09-04 Matteo Campo , Simon K. Schnyder , John J. Molina , Thomas Speck , Ryoichi Yamamoto

Shared upstream dynamical processes are frequently the source of common inputs in various physical and biological systems. However, due to finite signal transmission speeds and differences in the distance to the source, time shifts between…

神经元与认知 · 定量生物学 2017-03-10 Ehsan Bolhasani , Yousef Azizi , Alireza Valizadeh , Matjaz Perc

We report experimental studies of synchronization phenomena in a pair of biological neurons that interact through naturally occurring, electrical coupling. When these neurons generate irregular bursts of spikes, the natural coupling…

The dynamics of three mutually coupled cortical neurons with time delays in the coupling are explored numerically and analytically. The neurons are coupled in a line, with the middle neuron sending a somewhat stronger projection to the…

混沌动力学 · 物理学 2011-01-25 Alexandra S. Landsman , Ira B. Schwartz

We study the dynamics of phase synchronization in growing populations of discrete phase oscillatory systems when the division process is coupled to the distribution of oscillator phases. Using mean field theory, linear stability analysis,…

统计力学 · 物理学 2015-06-16 Wen Yu , Kevin B. Wood

Mounting evidence shows that oscillatory activity is widespread in cell signaling. Here we review some of this recent evidence, focusing on both the molecular mechanisms that potentially underlie such dynamical behavior, and the potential…

细胞行为 · 定量生物学 2022-04-15 Pablo Casani-Galdon , Jordi Garcia-Ojalvo

The mechanism of synchronization of oscillations in two identical coupled flow systems has beenstudied. The time (past the coupling onset) during which a synchronous oscillation regime is establisheddepends on the oscillation phase…

混沌动力学 · 物理学 2015-06-26 A. A. Koronovskii , A. E. Hramov , I. A. Khromova

Nonlocally coupled oscillators with a phase lag self-organize into various patterns such as global synchronization, the twisted state, and the chimera state. In this paper, we consider nonlocally coupled oscillators that move on a ring by…

适应与自组织系统 · 物理学 2022-11-17 Bojun Li , Nariya Uchida

The temporal behaviour of segmentation clock oscillations show phase synchrony via mean field like coupling of delta protein restricting to nearest neighbours only, in a configuration of cells arranged in a regular three dimensional array.…

Many biological systems synchronize their movement through physical interactions. By far the most well studied examples concern physical interactions through a fluid: beating cilia, swimming sperm and worms, and flapping wings, all display…

适应与自组织系统 · 物理学 2021-09-15 Wei Zhou , Zhuonan Hao , Nick Gravish

Pancreatic beta cells are coupled excitable oscillators that synchronize their activity via different communication pathways. Their oscillatory activity manifests itself on multiple timescales and consists of bursting electrical activity,…

生物物理 · 物理学 2023-09-14 Marko Šterk , Uroš Barać , Andraž Stožer , Marko Gosak

We examine microscopic mechanisms for coupling stochastic oscillators so that they display similar and correlated temporal variations. Unlike oscillatory motion in deterministic dynamical systems, complete synchronization of stochastic…

定量方法 · 定量生物学 2009-09-29 Amitabha Nandi , G. Santhosh , R. K. Brojen Singh , Ram Ramaswamy
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