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The identification of latent mediator variables is typically conducted using standard structural equation models (SEMs). When SEM is applied to mediation analysis with a causal interpretation, valid inference relies on the strong assumption…

统计方法学 · 统计学 2025-10-02 Sofia Morelli , Roberto Faleh , Holger Brandt

Unobserved confounding presents a major threat to causal inference from observational studies. Recently, several authors suggest that this problem may be overcome in a shared confounding setting where multiple treatments are independent…

统计方法学 · 统计学 2020-11-25 Dehan Kong , Shu Yang , Linbo Wang

This paper aims to provide practitioners of causal mediation analysis with a better understanding of estimation options. We take as inputs two familiar strategies (weighting and model-based prediction) and a simple way of combining them…

Researchers are often interested in learning not only the effect of treatments on outcomes, but also the pathways through which these effects operate. A mediator is a variable that is affected by treatment and subsequently affects outcome.…

统计方法学 · 统计学 2021-12-22 Jeremiah Jones , Ashkan Ertefaie , Robert L. Strawderman

Many causal models of interest in epidemiology involve longitudinal exposures, confounders and mediators. However, repeated measurements are not always available or used in practice, leading analysts to overlook the time-varying nature of…

统计方法学 · 统计学 2023-02-21 Lola Etievant , Vivian Viallon

Random-effects meta-analyses of observational studies can produce biased estimates if the synthesized studies are subject to unmeasured confounding. We propose sensitivity analyses quantifying the extent to which unmeasured confounding of…

统计方法学 · 统计学 2017-10-10 Maya B. Mathur , Tyler J. VanderWeele

Heterogeneity and comorbidity are two interwoven challenges associated with various healthcare problems that greatly hampered research on developing effective treatment and understanding of the underlying neurobiological mechanism. Very few…

统计方法学 · 统计学 2023-06-27 Richard A Watson , Hengrui Cai , Xinming An , Samuel McLean , Rui Song

Understanding the pathways whereby an intervention has an effect on an outcome is a common scientific goal. A rich body of literature provides various decompositions of the total intervention effect into pathway specific effects.…

统计方法学 · 统计学 2020-01-20 David Benkeser

Proxy variables are commonly used in causal inference when unmeasured confounding exists. While most existing proximal methods assume a unidirectional causal relationship between two primary variables, many social and biological systems…

统计方法学 · 统计学 2025-07-21 Jiaqi Min , Xueyue Zhang , Shanshan Luo

The notion of causality assumes a paramount position within the realm of human cognition. Over the past few decades, there has been significant advancement in the domain of causal effect estimation across various disciplines, including but…

机器学习 · 统计学 2024-05-24 Zongyu Li , Xiaobo Guo , Siwei Qiang

Causality has traditionally been a scientific way to generate knowledge by relating causes to effects. From an imaginery point of view, causal graphs are a helpful tool for representing and infering new causal information. In previous…

人工智能 · 计算机科学 2020-02-07 Eduardo C. Garrido-Merchán , C. Puente , A. Sobrino , J. A. Olivas

Interference bias is a major impediment to identifying causal effects in real-world settings. For example, vaccination reduces the transmission of a virus in a population such that everyone benefits -- even those who are not treated. This…

统计方法学 · 统计学 2025-03-25 Michael O'Riordan , Ciarán M. Gilligan-Lee

Decomposing a total causal effect into natural direct and indirect effects is central to revealing causal mechanisms. Conventional methods achieve the decomposition by specifying an outcome model as a linear function of the treatment, the…

统计方法学 · 统计学 2025-06-05 Guanglei Hong

Joint models for a wide class of response variables and longitudinal measurements consist on a mixed-effects model to fit longitudinal trajectories whose random effects enter as covariates in a generalized linear model for the primary…

统计方法学 · 统计学 2014-07-03 Rolando De la Cruz , Cristian Meza , Ana Arribas-Gil , Raymond J. Carroll

Mediation analyses play important roles in making causal inference in biomedical research to examine causal pathways that may be mediated by one or more intermediate variables (i.e., mediators). Although mediation frameworks have been well…

应用统计 · 统计学 2023-01-25 Meilin Jiang , Seonjoo Lee , James O'Malley , Yaakov Stern , Zhigang Li

We propose a novel approach for causal mediation analysis based on changes-in-changes assumptions restricting unobserved heterogeneity over time. This allows disentangling the causal effect of a binary treatment on a continuous outcome into…

计量经济学 · 经济学 2020-10-13 Martin Huber , Mark Schelker , Anthony Strittmatter

Probabilistic Graphical Bayesian models of causation have continued to impact on strategic analyses designed to help evaluate the efficacy of different interventions on systems. However, the standard causal algebras upon which these…

统计方法学 · 统计学 2024-04-08 Preetha Ramiah , James Q. Smith , Oliver Bunnin , Silvia Liverani , Jamie Addison , Annabel Whipp

In the field of disparities research, there has been growing interest in developing a counterfactual-based decomposition analysis to identify underlying mediating mechanisms that help reduce disparities in populations. Despite rapid…

统计方法学 · 统计学 2022-05-27 Soojin Park , Chioun Lee , Xu Qin

This paper clarifies a fundamental difference between causal inference and traditional statistical inference by formalizing a mathematical distinction between their respective parameters. We connect two major approaches to causal inference,…

统计方法学 · 统计学 2025-08-29 Muye Liu , Jun Xie

We consider the problem of answering observational, interventional, and counterfactual queries in a causally sufficient setting where only observational data and the causal graph are available. Utilizing the recent developments in diffusion…

机器学习 · 统计学 2024-10-11 Patrick Chao , Patrick Blöbaum , Sapan Patel , Shiva Prasad Kasiviswanathan