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Neuronal excitability is the phenomena that describes action potential generation due to a stimulus input. Commonly, neuronal excitability is divided into two classes: Type I and Type II, both having different properties that affect…

神经元与认知 · 定量生物学 2020-11-03 Jantine A. C. Broek , Guillaume Drion

Being an example for a relaxation oscillator, the FitzHugh-Nagumo model has been widely employed for describing the generation of action potentials. In this paper, we begin with a biological interpretation of what the subsequent…

数值分析 · 数学 2025-01-31 Burcu Gürbüz , Aytül Gökçe , Mahmut Modanlı

We study the phenomenological model of ensemble of two FitzHugh-Nagumo neuron-like elements with symmetric excitatory couplings. The main advantage of proposed model is the new approach to model of coupling which is implemented by smooth…

The FitzHugh-Nagumo equation, originally conceived in neuroscience during the 1960s, became a key model providing a simplified view of excitable neuron cell behavior. Its applicability, however, extends beyond neuroscience into fields like…

斑图形成与孤子 · 物理学 2025-01-08 Daniel Cebrián-Lacasa , Pedro Parra-Rivas , Daniel Ruiz-Reynés , Lendert Gelens

The Fitzhugh-Nagumo neuronal model is used to explore the influence of the electric field on thermosensitive neurons' dynamics. This study investigates how the electric field affects polarization modulation in cell media induced by changes…

混沌动力学 · 物理学 2025-02-13 Ediline L. F. Nguessap , Fernando F. Ferreira , Antonio C. Roque

We consider the coaction of two distinct noise sources on the activation process of a single and two interacting excitable units, which are mathematically described by the Fitzhugh-Nagumo equations. We determine the most probable activation…

混沌动力学 · 物理学 2016-04-19 Igor Franović , Kristina Todorović , Matjaz Perc , Nebojša Vasović , Nikola Burić

This article communicates results on regular depolarization cascades in periodically-kicked feedforward chains of excitable two-dimensional FitzHugh-Nagumo systems driven by sufficiently strong excitatory forcing at the front node. The…

动力系统 · 数学 2021-12-21 B. Ambrosio , S. M. Mintchev

Fifty years ago, Fitzugh introduced a phase portrait that became famous for a twofold reason: it captured in a physiological way the qualitative behavior of Hodgkin-Huxley model and it revealed the power of simple dynamical models to unfold…

动力系统 · 数学 2011-12-13 Alessio Franci , Guillaume Drion , Vincent Seutin , Rodolphe Sepulchre

We investigate a possibility of realization of structurally stable chaotic dynamics in neural systems. The considered model of interacting neurons consists of a pair of coupled FitzHugh-Nagumo systems, with the parameters being periodically…

混沌动力学 · 物理学 2017-03-07 Alexey Yu. Jalnine

According to the conventional approach to model neural ensembles the extracellular environment has fixed ionic concentrations. However, in many cases the extracellular concentration of potassium ions can not be regarded as constant. That…

无序系统与神经网络 · 物理学 2015-05-13 D. E. Postnov , F. Müller , R. B. Schuppner , L. Schimansky-Geier

Neurons are the central biological objects in understanding how the brain works. The famous Hodgkin-Huxley model, which describes how action potentials of a neuron are initiated and propagated, consists of four coupled nonlinear…

神经元与认知 · 定量生物学 2010-02-01 William Hanan , Dhagash Mehta , Guillaume Moroz , Sepanda Pouryahya

This chapter revisits the concept of excitability, a basic system property of neurons. The focus is on excitable systems regarded as behaviors rather than dynamical systems. By this we mean open systems modulated by specific interconnection…

神经元与认知 · 定量生物学 2017-04-18 Rodolphe Sepulchre , Guillaume Drion , Alessio Franci

Using the standard van der Pol-FitzHugh-Nagumo excitable medium model I demonstrate a novel generic mechanism, diversity, that provokes the emergence of global oscillations from individually quiescent elements in heterogeneous excitable…

混沌动力学 · 物理学 2012-07-24 Julyan H. E. Cartwright

We study the interplay between diversity and noise in a 3D network of FitzHugh-Nagumo elements, with topology and dimensions chosen to model a pancreatic beta-cell cluster, as an example of an excitable cell network. Our results show that…

生物物理 · 物理学 2022-03-30 Stefano Scialla , Marco Patriarca , Els Heinsalu

We use the qualitative insight of a planar neuronal phase portrait to detect an excitability switch in arbitrary conductance-based models from a simple mathematical condition. The condition expresses a balance between ion channels that…

神经元与认知 · 定量生物学 2015-06-11 Alessio Franci , Guillaume Drion , Vincent Seutin , Rodolphe Sepulchre

An electronic circuit device, inspired on the FitzHugh-Nagumo model of neuronal excitability, was constructed and shown to operate with characteristics compatible with those of biological sensory neurons. The nonlinear dynamical model of…

We consider the problem of initiation of propagating wave in a one-dimensional excitable fiber. In the FitzHugh-Nagumo theory, the key role is played by ``critical nucleus'' and ``critical pulse'' solutions whose (center-)stable manifold is…

斑图形成与孤子 · 物理学 2009-11-13 I. Idris , V. N. Biktashev

We study the nonlinear dynamics of two delay-coupled neural systems each modelled by excitable dynamics of FitzHugh-Nagumo type and demonstrate that bistability between the stable fixed point and limit cycle oscillations occurs for…

斑图形成与孤子 · 物理学 2015-05-13 M. A. Dahlem , G. Hiller , A. Panchuk , E. Schoell

We focus on the qualitative analysis of a reaction-diffusion with spatial heterogeneity. The system is a generalization of the well known FitzHugh-Nagumo system in which the excitability parameter is space dependent. This heterogeneity…

动力系统 · 数学 2017-06-28 B. Ambrosio

This paper introduces a model of excitability that unifies the mechanism of an important neuronal property both in time and in space. As a starting point, we revisit both a key model of temporal excitability, proposed by Hodgkin and Huxley,…

系统与控制 · 电气工程与系统科学 2025-05-29 Thomas SJ Burger , Amir Shahhosseini , Rodolphe Sepulchre
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