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Large-scale biobanks are being collected around the world in efforts to better understand human health and risk factors for disease. They often survey hundreds of thousands of individuals, combining questionnaires with clinical, genetic,…

A common feature in many neuroscience datasets is the presence of hierarchical data structures, most commonly recording the activity of multiple neurons in multiple animals across multiple trials. Accordingly, the measurements constituting…

神经元与认知 · 定量生物学 2020-07-17 Varun Saravanan , Gordon J Berman , Samuel J Sober

In light of the inherently complex and dynamic nature of real-world environments, incorporating risk measures is crucial for the robustness evaluation of deep learning models. In this work, we propose a Risk-Averse Certification framework…

机器学习 · 计算机科学 2024-12-02 Xiyue Zhang , Zifan Wang , Yulong Gao , Licio Romao , Alessandro Abate , Marta Kwiatkowska

We present a novel approach for training deep neural networks in a Bayesian way. Classical, i.e. non-Bayesian, deep learning has two major drawbacks both originating from the fact that network parameters are considered to be deterministic.…

机器学习 · 统计学 2019-03-11 Konstantin Posch , Jan Steinbrener , Jürgen Pilz

We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

机器学习 · 计算机科学 2018-01-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

We address the problem of providing inference from a Bayesian perspective for parameters selected after viewing the data. We present a Bayesian framework for providing inference for selected parameters, based on the observation that…

统计计算 · 统计学 2015-03-13 Daniel Yekutieli

False discovery rate (FDR) has been widely used as an error measure in large scale multiple testing problems, but most research in the area has been focused on procedures for controlling the FDR based on independent test statistics or the…

统计方法学 · 统计学 2009-09-29 Weihua Tang , Cun-Hui Zhang

Convolutional neural networks (CNNs) work well on large datasets. But labelled data is hard to collect, and in some applications larger amounts of data are not available. The problem then is how to use CNNs with small data -- as CNNs…

机器学习 · 统计学 2016-01-19 Yarin Gal , Zoubin Ghahramani

Randomized benchmarking (RB) protocols are standard tools for characterizing quantum devices. Prior analyses of RB protocols have not provided a complete method for analyzing realistic data, resulting in a variety of ad-hoc methods. The…

量子物理 · 物理学 2018-02-02 Ian Hincks , Joel J. Wallman , Chris Ferrie , Chris Granade , David G. Cory

High-throughput screening techniques are commonly used to obtain large quantities of data in many fields of biology. It is well known that artifacts arising from variability in the technical execution of different experimental batches…

Screening mammograms is the gold standard for detecting breast cancer early. While a good amount of work has been performed on mammography image classification, especially with deep neural networks, there has not been much exploration into…

机器学习 · 计算机科学 2020-08-14 Anika Tabassum , Naimul Khan

Model inadequacy and measurement uncertainty are two of the most confounding aspects of inference and prediction in quantitative sciences. The process of scientific inference (the inverse problem) and prediction (the forward problem)…

数据分析、统计与概率 · 物理学 2017-11-30 Amir Shahmoradi

Deep Neural Networks (DNNs) are increasingly utilized in high-stakes domains like medical diagnostics and autonomous driving where model reliability is critical. However, the research landscape for ensuring this reliability is…

机器学习 · 计算机科学 2026-04-07 Ole Delzer , Sidney Bender

MicroRNAs (miRNAs) are small RNA molecules, about 22 nucleotide long, which post-transcriptionally regulate their target messenger RNAs (mRNAs). They accomplish key roles in gene regulatory networks, ranging from signaling pathways to…

分子网络 · 定量生物学 2012-10-09 Carla Bosia , Andrea Pagnani , Riccardo Zecchina

Correct inference of genetic regulations inside a cell is one of the greatest challenges in post genomic era for the biologist and researchers. Several intelligent techniques and models were already proposed to identify the regulatory…

人工智能 · 计算机科学 2017-08-03 Sudip Mandal , Goutam Saha , Rajat K. Pal

Next-generation sequencing technologies provide a revolutionary tool for generating gene expression data. Starting with a fixed RNA sample, they construct a library of millions of differentially abundant short sequence tags or "reads",…

定量方法 · 定量生物学 2014-05-13 Dimitrios V. Vavoulis , Julian Gough

Cellular response to a perturbation is the result of a dynamic system of biological variables linked in a complex network. A major challenge in drug and disease studies is identifying the key factors of a biological network that are…

应用统计 · 统计学 2014-09-02 Lisa M. Pham , Luis Carvalho , Scott Schaus , Eric D. Kolaczyk

The mitigation of false positives is an important issue when conducting multiple hypothesis testing. The most popular paradigm for false positives mitigation in high-dimensional applications is via the control of the false discovery rate…

统计方法学 · 统计学 2018-07-17 Hien D. Nguyen , Yohan Yee , Geoffrey J. McLachlan , Jason P. Lerch

Contamination by Radio Frequency Interference (RFI) is a ubiquitous challenge for radio astronomy. In particular, transient RFI is difficult to detect and avoid, especially in large data sets with many time bins. In this work, we present a…

天体物理仪器与方法 · 物理学 2023-10-04 Dominic Anstey , Samuel A. K. Leeney

Respiratory rate (RR) is an important biomarker as RR changes can reflect severe medical events such as heart disease, lung disease, and sleep disorders. Unfortunately, standard manual RR counting is prone to human error and cannot be…