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We study the emergence of cell differentiation under the assumption of the existence of a given number of tradeoffs between genes encoding different functions. In the model the viability of colonies is determined by the capability of their…

种群与进化 · 定量生物学 2017-06-06 André Amado , Paulo R. A. Campos

We explore and quantify the physical and biochemical mechanisms that may be relevant in the regulation of translation. After elongation and detachment from the 3' termination site of mRNA, parts of the ribosome machinery can diffuse back to…

软凝聚态物质 · 物理学 2009-11-10 Tom Chou

Cellular renewing active matter - assemblies of proliferating and apoptotic cells - underlies tissue homeostasis, morphogenesis, and clonal competition. Previous work in one-dimensional periodic systems identified a fitness advantage…

软凝聚态物质 · 物理学 2025-12-02 Patrick Zimmer , Philip Bittihn , Yoav G. Pollack

A central model in theoretical ecology considers the competition of a range of species for a broad spectrum of resources. Recent studies have shown that essentially two different outcomes are possible. Either the species surviving…

种群与进化 · 定量生物学 2010-04-05 Simone Pigolotti , Cristobal Lopez , Emilio Hernandez-Garcia , Ken Haste Andersen

We revisit a totally asymmetric simple exclusion process (TASEP) with open boundaries and a global constraint on the total number of particles [Adams, et. al. 2008 J. Stat. Mech. P06009]. In this model, the entry rate of particles into the…

统计力学 · 物理学 2009-08-30 L. Jonathan Cook , R. K. P. Zia

Understanding to what extent stem cell potential is a cell-intrinsic property, or an emergent behavior coming from global tissue dynamics and geometry, is a key outstanding question of systems and stem cell biology. Here, we propose a…

A system consisting of two parallel coupled channels where particles in one of them follow the rules of totally asymmetric exclusion processes (TASEP) and in another one move as in symmetric simple exclusion processes (SSEP) is investigated…

统计力学 · 物理学 2009-11-13 K. Tsekouras , A. B. Kolomeisky

We study mixing times of the symmetric and asymmetric simple exclusion process on the segment where particles are allowed to enter and exit at the endpoints. We consider different regimes depending on the entering and exiting rates as well…

概率论 · 数学 2022-05-03 Nina Gantert , Evita Nestoridi , Dominik Schmid

The totally asymmetric simple exclusion process (TASEP) is a basic model of statistical mechanics that has found numerous applications. We consider the case of TASEP with a finite chain where particles may enter from the left and leave to…

动力系统 · 数学 2020-06-23 Lars Grüne , Thomas Kriecherbauer , Michael Margaliot

Ecosystems are commonly organized into trophic levels -- organisms that occupy the same level in a food chain (e.g., plants, herbivores, carnivores). A fundamental question in theoretical ecology is how the interplay between trophic…

种群与进化 · 定量生物学 2023-03-07 Zhijie Feng , Robert Marsland , Jason W. Rocks , Pankaj Mehta

In the process of translation, ribosomes read the genetic code on an mRNA and assemble the corresponding polypeptide chain. The ribosomes perform discrete directed motion which is well modeled by a totally asymmetric simple exclusion…

生物大分子 · 定量生物学 2007-08-02 J. J. Dong , B. Schmittmann , R. K. P. Zia

We study how increasing competition, by making prizes more unequal, affects effort in contests. In a finite type-space environment, we characterize the equilibrium, analyze the effect of competition under linear costs, and identify…

理论经济学 · 经济学 2025-02-13 Andrzej Baranski , Sumit Goel

The capacity of distant parties to send signals to one another is a fundamental requirement in many information-processing tasks. Such ability is determined by the causal structure connecting the parties, and more generally, by the…

量子物理 · 物理学 2022-08-31 Simon Milz , Jessica Bavaresco , Giulio Chiribella

We study the effects of randomness on competitions based on an elementary random process in which there is a finite probability that a weaker team upsets a stronger team. We apply this model to sports leagues and sports tournaments, and…

物理与社会 · 物理学 2013-04-02 E. Ben-Naim , N. W. Hengartner , S. Redner , F. Vazquez

The evolution of multicellularity was a major transition in the history of life on earth. Conditions under which multicellularity is favored have been studied theoretically and experimentally. But since the construction of a multicellular…

种群与进化 · 定量生物学 2018-03-19 Jason Olejarz , Kamran Kaveh , Carl Veller , Martin A. Nowak

In this paper we consider a model of particles jumping on a row of cells, called in physics the one dimensional totally asymmetric exclusion process (TASEP). More precisely we deal with the TASEP with open or periodic boundary conditions…

组合数学 · 数学 2007-05-23 Enrica Duchi , Gilles Schaeffer

It is known that the competitive exclusion principle holds for a large kind of models involving several species competing for a single resource in an homogeneous environment. Various works indicate that the coexistence is possible in an…

偏微分方程分析 · 数学 2014-07-22 François Castella , Sten Madec , Yvan Lagadeuc

All cells must keep time to consistently perform vital biological functions. To that end, the coupling and interrelatedness of diverse subsecond events in the complex cellular environment, such as protein folding or translation rates,…

亚细胞过程 · 定量生物学 2012-10-02 Sepehr Ehsani

We study the totally asymmetric simple exclusion process (TASEP) on $\mathbb{Z}$ with step initial condition, in which all particles have distinct types. Our main object of interest is the type of the rightmost particle -- the leader -- at…

概率论 · 数学 2026-01-30 Alexei Borodin , Alexey Bufetov

Consider a population of agents who repeatedly compete for awards, as in the case of researchers annually applying for grants. Noise in the selection process may encourage entry of low quality proposals, forcing the principal to commit…

理论经济学 · 经济学 2024-11-28 Yaron Azrieli