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Stochastic simulation is a widely used method for estimating quantities in models of chemical reaction networks where uncertainty plays a crucial role. However, reducing the statistical uncertainty of the corresponding estimators requires…

定量方法 · 定量生物学 2019-06-13 Michael Backenköhler , Luca Bortolussi , Verena Wolf

This study performs parameter inference in a partial differential equations system of pulmonary circulation. We use a fluid dynamics network model that takes selected parameter values and mimics the behaviour of the pulmonary haemodynamics…

Graph neural networks are often used to model interacting dynamical systems since they gracefully scale to systems with a varying and high number of agents. While there has been much progress made for deterministic interacting systems,…

机器学习 · 计算机科学 2023-05-04 Andreas Look , Melih Kandemir , Barbara Rakitsch , Jan Peters

Reaction networks are widely used models to describe biochemical processes. Stochastic fluctuations in the counts of biological macromolecules have amplified consequences due to their small population sizes. This makes it necessary to favor…

概率论 · 数学 2022-02-28 Daniele Cappelletti , Badal Joshi

Discrete-state, continuous-time Markov models are becoming commonplace in the modelling of biochemical processes. The mathematical formulations that such models lead to are opaque, and, due to their complexity, are often considered…

定量方法 · 定量生物学 2017-10-31 Christopher Lester

In this paper, we focus on activating only a few sensors, among many available, to estimate the state of a stochastic process of interest. This problem is important in applications such as target tracking and simultaneous localization and…

系统与控制 · 计算机科学 2016-09-28 Vasileios Tzoumas , Nikolay A. Atanasov , Ali Jadbabaie , George J. Pappas

We consider stochastic reaction networks modeled by continuous-time Markov chains. Such reaction networks often contain many reactions, potentially occurring at different time scales, and have unknown parameters (kinetic rates, total…

概率论 · 数学 2023-02-20 Linard Hoessly , Carsten Wiuf

Reaction networks are often used to model interacting species in fields such as biochemistry and ecology. When the counts of the species are sufficiently large, the dynamics of their concentrations are typically modeled via a system of…

数值分析 · 数学 2022-01-05 David F. Anderson , Kurt W. Ehlert

We address the problem of simulation and parameter inference for chemical reaction networks described by the chemical Langevin equation, a stochastic differential equation (SDE) representation of the dynamics of the chemical species. This…

统计方法学 · 统计学 2025-08-18 Petar Jovanovski , Andrew Golightly , Umberto Picchini , Massimiliano Tamborrino

This paper takes a different approach for the distributed linear parameter estimation over a multi-agent network. The parameter vector is considered to be stochastic with a Gaussian distribution. The sensor measurements at each agent are…

系统与控制 · 电气工程与系统科学 2022-04-19 Subhro Das

Inference in Gaussian process (GP) models is computationally challenging for large data, and often difficult to approximate with a small number of inducing points. We explore an alternative approximation that employs stochastic inference…

机器学习 · 统计学 2019-05-28 Jiaxin Shi , Mohammad Emtiyaz Khan , Jun Zhu

Focusing on identification, this paper develops techniques to reconstruct zero and nonzero elements of a sparse parameter vector of a stochastic dynamic system under feedback control, for which the current input may depend on the past…

系统与控制 · 电气工程与系统科学 2019-09-04 Wenxiao Zhao , George G. Yin , Er-Wei Bai

We present a novel multiscale simulation approach for modeling stochasticity in chemical reaction networks. The approach seamlessly integrates exact-stochastic and "leaping" methodologies into a single "partitioned leaping" algorithmic…

化学物理 · 物理学 2009-11-11 Leonard A. Harris , Paulette Clancy

Biological systems commonly exhibit complex spatiotemporal patterns whose underlying generative mechanisms pose a significant analytical challenge. Traditional approaches to spatiodynamic inference rely on dimensionality reduction through…

定量方法 · 定量生物学 2025-08-01 Jun Won Park , Kangyu Zhao , Sanket Rane

Machine learning models trained with structural health monitoring data have become a powerful tool for system identification. This paper presents a physics-informed Gaussian process (GP) model for Timoshenko beam elements. The model is…

机器学习 · 计算机科学 2023-09-22 Gledson Rodrigo Tondo , Sebastian Rau , Igor Kavrakov , Guido Morgenthal

Estimation and prediction in high dimensional multivariate factor stochastic volatility models is an important and active research area because such models allow a parsimonious representation of multivariate stochastic volatility. Bayesian…

统计计算 · 统计学 2021-04-27 David Gunawan , Robert Kohn , David Nott

A highly efficient formulation of moment equations for stochastic reaction networks is introduced. It is based on a set of binomial moments that capture the combinatorics of the reaction processes. The resulting set of equations can be…

统计力学 · 物理学 2015-05-20 Baruch Barzel , Ofer Biham

We propose a framework to perform streaming covariance selection. Our approach employs regularization constraints where a time-varying sparsity parameter is iteratively estimated via stochastic gradient descent. This allows for the…

This paper proposes a general switching dynamical system model, and a custom majorization-minimization-based algorithm EM++ for identifying its parameters. For certain families of distributions, such as Gaussian distributions, this…

最优化与控制 · 数学 2025-12-30 Renzi Wang , Alexander Bodard , Mathijs Schuurmans , Panagiotis Patrinos

Recent studies in the field of human vision science suggest that the human responses to the stimuli on a visual display are non-deterministic. People may attend to different locations on the same visual input at the same time. Based on this…

计算机视觉与模式识别 · 计算机科学 2015-03-13 Akisato kimura , Derek Pang , Tatsuto Takeuchi , Kouji Miyazato , Junji Yamato , Kunio Kashino