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This paper tackles the challenge of parameter calibration in stochastic models, particularly in scenarios where the likelihood function is unavailable in an analytical form. We introduce a gradient-based simulated parameter estimation…

机器学习 · 统计学 2025-03-25 Zehao Li , Yijie Peng

Several different methods exist for efficient approximation of paths in multiscale stochastic chemical systems. Another approach is to use bursts of stochastic simulation to estimate the parameters of a stochastic differential equation…

数值分析 · 数学 2014-12-19 Simon Cotter , Radek Erban

System identification is of special interest in science and engineering. This article is concerned with a system identification problem arising in stochastic dynamic systems, where the aim is to estimate the parameters of a system along…

统计方法学 · 统计学 2022-01-27 Christos Merkatas , Simo Särkkä

Network inference has been extensively studied in several fields, such as systems biology and social sciences. Learning network topology and internal dynamics is essential to understand mechanisms of complex systems. In particular, sparse…

机器学习 · 统计学 2022-06-13 Yasen Wang , Junyang Jin , Jorge Goncalves

Non linear regression models are a standard tool for modeling real phenomena, with several applications in machine learning, ecology, econometry... Estimating the parameters of the model has garnered a lot of attention during many years. We…

统计理论 · 数学 2020-09-17 Peggy Cénac , Antoine Godichon-Baggioni , Bruno Portier

We present a novel method to improve pharmacokinetics modeling, an essential step of drug development. Conventional models frequently fail to fully represent the intricacies of drug absorption and distribution, which limits their predictive…

定量方法 · 定量生物学 2024-12-31 Nazanin Ahmadi , Shupeng Wang , George Karniadakis

Markov chains are fundamental models for stochastic dynamics, with applications in a wide range of areas such as population dynamics, queueing systems, reinforcement learning, and Monte Carlo methods. Estimating the transition matrix and…

统计理论 · 数学 2026-01-26 Lasse Leskelä , Maximilien Dreveton

Switching dynamical systems are an expressive model class for the analysis of time-series data. As in many fields within the natural and engineering sciences, the systems under study typically evolve continuously in time, it is natural to…

机器学习 · 计算机科学 2022-05-19 Lukas Köhs , Bastian Alt , Heinz Koeppl

Modeling stochastic traffic behaviors at the microscopic level, such as car-following and lane-changing, is a crucial task to understand the interactions between individual vehicles in traffic streams. Leveraging a recently developed theory…

机器学习 · 统计学 2020-07-21 Yun Yuan , Qinzheng Wang , Xianfeng Terry Yang

Stochastic modelling provides an indispensable tool for understanding how random events at the molecular level influence cellular functions. In practice, the common challenge is to calibrate a large number of model parameters against the…

分子网络 · 定量生物学 2015-03-17 Shuohao Liao , Tomas Vejchodsky , Radek Erban

This work proposes a new method for simultaneous probabilistic identification and control of an observable, fully-actuated mechanical system. Identification is achieved by conditioning stochastic process priors on observations of…

机器学习 · 计算机科学 2014-04-02 Jan-Peter Calliess , Antonis Papachristodoulou , Stephen J. Roberts

We provide a simple method to estimate the parameters of multivariate stochastic volatility models with latent factor structures. These models are very useful as they alleviate the standard curse of dimensionality, allowing the number of…

计量经济学 · 经济学 2023-02-15 Giorgio Calzolari , Roxana Halbleib , Christian Mücher

We propose a method to efficiently determine the optimal coarse-grained force field in mesoscopic stochastic simulations of Newtonian fluid and polymer melt systems modeled by dissipative particle dynamics (DPD) and energy conserving…

计算物理 · 物理学 2017-01-04 Huan Lei , Xiu Yang , Zhen Li , George Karniadakis

Many machine learning problems can be framed in the context of estimating functions, and often these are time-dependent functions that are estimated in real-time as observations arrive. Gaussian processes (GPs) are an attractive choice for…

We propose a universal approach for analysis and fast simulations of stiff stochastic biochemical kinetics networks, which rests on elimination of fast chemical species without a loss of information about mesoscopic, non-Poissonian…

分子网络 · 定量生物学 2009-07-07 N. A. Sinitsyn , Nicolas Hengartner , Ilya Nemenman

Gaussian process state-space models (GPSSMs) provide a principled and flexible approach to modeling the dynamics of a latent state, which is observed at discrete-time points via a likelihood model. However, inference in GPSSMs is…

机器学习 · 计算机科学 2023-07-18 Xuhui Fan , Edwin V. Bonilla , Terence J. O'Kane , Scott A. Sisson

Many problems in the geophysical sciences demand the ability to calibrate the parameters and predict the time evolution of complex dynamical models using sequentially-collected data. Here we introduce a general methodology for the joint…

统计计算 · 统计学 2018-12-12 Sara Pérez-Vieites , Inés P. Mariño , Joaquín Míguez

Under mass-action kinetics, biochemical reaction networks give rise to polynomial autonomous dynamical systems whose parameters are often difficult to estimate. We deal in this paper with the problem of identifying the kinetic parameters of…

分子网络 · 定量生物学 2019-04-26 Gabriela Jeronimo , Mercedes Pérez Millán , Pablo Solernó

We introduce a response-theoretic framework that recasts parameter calibration of ergodic stochastic differential equations as a fluctuation-dissipation problem. Our central result is that the full Jacobian of any stationary observable with…

混沌动力学 · 物理学 2026-04-02 Ludovico T. Giorgini , Tobias Bischoff , Andre N. Souza

Gaussian processes have become a popular tool for nonparametric regression because of their flexibility and uncertainty quantification. However, they often use stationary kernels, which limit the expressiveness of the model and may be…

机器学习 · 计算机科学 2025-07-17 Zachary James , Joseph Guinness