相关论文: Model of pathogenesis of psoriasis. Part 1. System…
Analytical research of results of experimental and theoretical studies on pathogenesis of psoriatic disease is carried out. The new model of pathogenesis - skin reaction to systemic psoriatic process SPP is formulated. ... Psoriatic…
A review of recent investigations into pathogenesis of psoriasis summarizing data on the relationship between the presence {\beta}-streptococci in the organism and the cutaneous immune reaction. Results of the studies on gastrointestinal…
A review of recent investigations into pathogenesis of psoriasis summarizing data on the relationship between the presence beta-streptococci in the organism and the cutaneous immune reaction. Results of the studies on gastrointestinal…
Disease psoriasis occurs as chronic inflammation of skin and appears as scaly red lesions on skin surface. Advent of several immunosuppressive drugs established that the disease stems from immuno-pathogenic disorder in human blood. Cell…
We present a computational model to study the spatiotemporal dynamics of the epidermis homeostasis under normal and pathological conditions. The model consists of a population kinetics model of the central transition pathway of keratinocyte…
Background: Psoriasis is a multifactorial chronic inflammatory disorder of the skin with significant morbidity, characterized by hyper proliferation of the epidermis. Even though psoriasis etiology is not fully understood, it is believed to…
The skin microbiome plays an important role in the maintenance of a healthy skin. It is an ecosystem, composed of several species, competing for resources and interacting with the skin cells. Imbalance in the cutaneous microbiome, also…
Atherosclerosis is characterised by the growth of fatty plaques in the inner (intimal) layer of the artery wall. In mature plaques, vascular smooth muscle cells (SMCs) are recruited from the adjacent medial layer to deposit a cap of fibrous…
Pimple is one of the most common skin diseases for humans. The mechanical modeling of pimple growth is very limited. A finite element model is developed to quantify the deformation field with the expansion of follicle, and then the…
Multidrug resistance (MDR) to conventional antibiotics is one of the most urgent global health threats, necessitating the development of effective and biocompatible antimicrobial agents that are less inclined to provoke resistance.…
Despite being of vital importance to the immune system, the mechanism by which cells engulf relatively large solid particles during phagocytosis is still poorly understood. From movies of neutrophil phagocytosis of polystyrene beads, we…
From bird flocks and fish schools to migrating cell sheets, collective motion is a ubiquitous biological phenomenon that inspires quantitative modeling through self-propelled particle (SPP) frameworks. Conventional SPP models prescribe…
Various theoretical studies have been carried out to infer relevant protein-protein interactions among pathogens and their hosts. Such studies are generally based on preferential attachment of bacteria / virus to their human receptor…
Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…
Antimicrobial peptides (AMPs) have intrigued researchers for decades due to the contradiction between their high potential against resistant bacteria and the inability to find a structure-function relationship for the development of an…
The rheological properties of biological tissues, though fundamental to many physiological and pathological processes such as embryonic development, wound healing, and tumor progression, remain poorly understood. A recent study showed that…
In this work, we propose a dynamical systems perspective on the modeling of sepsis and its organ-damaging consequences. We develop a functional two-layer network model for sepsis based upon the interaction of parenchymal cells and immune…
Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors. A mathematical approach of this process is proposed…
The basic process of the innate immune system when phagocyte (white blood cell) engulf or swallow a target particle (bacterium or dead cell), is called phagocytosis. We apply the phase field approach in the spirit of [1], that couples the…
Biological processes like the sequestration of Superoxide Dismutase 1 (SOD1) into biomolecular condensates such as FUS and stress granules are essential to understanding disease mechanisms, including amyotrophic lateral sclerosis (ALS). Our…