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Hodgkin-Huxley equations as a monumental breakthrough in biological and physiological theory of the 20th century had been distilled into many simplified models to study, typically FitzHugh-Nagumo equations and Hindmarsh-Rose equations, but…

偏微分方程分析 · 数学 2026-05-11 Yuncheng You

Mathematical models for the generation of the action potential can improve the understanding of physiological mechanisms that are consequence of the electrical activity in neurons. In such models, some equations involving empirically…

神经元与认知 · 定量生物学 2023-04-05 Lautaro Estienne

We suggest that the propagation of the action potential is driven by a pressure pulse propagating in the axoplasm along the axon length. The pressure pulse mechanically activates Na ion channels embedded in the axon membrane. This…

生物物理 · 物理学 2009-05-15 Marat M. Rvachev

We consider a stochastic Hodgkin-Huxley model driven by a periodic signal as model for the membrane potential of a pyramidal neuron. The associated five dimensional diffusion process is a time inhomogeneous highly degenerate diffusion for…

概率论 · 数学 2012-07-03 Reinhard Höpfner , Eva Löcherbach , Michèle Thieullen

This paper deals with the long run average continuous control problem of piecewise deterministic Markov processes (PDMP's) taking values in a general Borel space and with compact action space depending on the state variable. The control…

概率论 · 数学 2008-09-03 O. L. V. Costa , F. Dufour

We treat the class of universal Markov processes on the d-dimensional Euklidean space which do not depend on random. For these, as well as for several subclasses, we prove criteria whether a function f, defined on the positive half-line,…

概率论 · 数学 2012-08-07 Alexander Schnurr

We describe a generalization of the Hierarchical Dirichlet Process Hidden Markov Model (HDP-HMM) which is able to encode prior information that state transitions are more likely between "nearby" states. This is accomplished by defining a…

机器学习 · 统计学 2017-07-24 Colin Reimer Dawson , Chaofan Huang , Clayton T. Morrison

We introduce a nonlinear modification of the classical Hawkes process, which allows inhibitory couplings between units without restrictions. The resulting system of interacting point processes provides a useful mathematical model for…

概率论 · 数学 2009-11-03 Stefano Cardanobile , Stefan Rotter

Piecewise deterministic Markov processes (PDMPs) are a class of continuous-time Markov processes that were recently used to develop a new class of Markov chain Monte Carlo algorithms. However, the implementation of the processes is…

统计计算 · 统计学 2024-08-08 Charly Andral , Kengo Kamatani

We propose to model the records of the maximum Drawdown in capital markets by means a Piecewise Deterministic Markov Process (PDMP). We derive statistical results such as the mean and variance that describes the sequence of maximum Drawdown…

风险管理 · 定量金融 2025-04-01 Rolando Rubilar-Torrealba , Lisandro Fermin , Soledad Torres

We consider a Markovian evolution on point processes, the $\Psi$--process, on the unit interval in which points are added according to a rule that depends only on the spacings of the existing point configuration. Having chosen a spacing, a…

概率论 · 数学 2020-07-01 Pascal Maillard , Elliot Paquette

Piecewise-deterministic Markov processes form a general class of non-diffusion stochastic models that involve both deterministic trajectories and random jumps at random times. In this paper, we state a new characterization of the jump rate…

统计方法学 · 统计学 2017-05-03 Romain Azaïs , Alexandre Genadot

The Hodgkin-Huxley model describes the conduction of the nervous impulse through the axon, whose membrane's electric response can be described employing multiple connected electric circuits containing capacitors, voltage sources, and…

神经元与认知 · 定量生物学 2021-12-13 Tasio Gonzalez-Raya , Enrique Solano , Mikel Sanz

We consider multiscale stochastic spatial gene networks involving chemical reactions and diffusions. The model is Markovian and the transitions are driven by Poisson random clocks. We consider a case where there are two different spatial…

概率论 · 数学 2020-07-10 Arnaud Debussche , Mac Jugal Nguepedja Nankep

We demonstrate that our recently developed theory of electric field wave propagation in anisotropic and inhomogeneous brain tissues, which has been shown to explain a broad range of observed coherent synchronous brain electrical processes,…

生物物理 · 物理学 2024-03-27 Vitaly L. Galinsky , Lawrence R. Frank

At the scale of the individual cell, protein production is a stochastic process with multiple time scales, combining quick and slow random steps with discontinuous and smooth variation. Hybrid stochastic processes, in particular…

分子网络 · 定量生物学 2019-05-02 Guilherme C. P. Innocentini , Fernando Antoneli , Arran Hodgkinson , Ovidiu Radulescu

The main goal of this paper is to derive sufficient conditions for the existence of an optimal control strategy for the long run average continuous control problem of piecewise deterministic Markov processes (PDMP's) taking values in a…

概率论 · 数学 2008-12-05 O. L. V. Costa , F. Dufour

The generation and conduction of action potentials represents a fundamental means of communication in the nervous system, and is a metabolically expensive process. In this paper, we investigate the energy efficiency of neural systems in a…

神经元与认知 · 定量生物学 2014-04-23 Lianchun Yu , Liwei Liu

Piecewise Deterministic Markov Processes (PDMPs) such as the Bouncy Particle Sampler and the Zig-Zag Sampler, have gained attention as continuous-time counterparts of classical Markov chain Monte Carlo. We study their transient regime under…

统计计算 · 统计学 2025-09-22 Sanket Agrawal , Joris Bierkens , Kengo Kamatani , Gareth O. Roberts

Oscillatory systems of interacting Hawkes processes with Erlang memory kernels were introduced in Ditlevsen (2017). They are piecewise deterministic Markov processes (PDMP) and can be approximated by a stochastic diffusion. First, a strong…

数值分析 · 数学 2020-03-25 Julien Chevallier , Anna Melnykova , Irene Tubikanec