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Background:Typically, proteins perform key biological functions by interacting with each other. As a consequence, predicting which protein pairs interact is a fundamental problem. Experimental methods are slow, expensive, and may be error…

生物大分子 · 定量生物学 2022-02-08 Leonardo Martini , Adriano Fazzone , Luca Becchetti

The inductive biases of trained neural networks are difficult to understand and, consequently, to adapt to new settings. We study the inductive biases of linearizations of neural networks, which we show to be surprisingly good summaries of…

The upcoming landscape of Earth Observation missions will defined by networked heterogeneous nanosatellite constellations required to meet strict mission requirements, such as revisit times and spatial resolution. However, scheduling…

信号处理 · 电气工程与系统科学 2024-03-05 Guillem Casadesus-Vila , Joan-Adria Ruiz-de-Azua , Eduard Alarcon

Protein (receptor)--ligand interaction prediction is a critical component in computer-aided drug design, significantly influencing molecular docking and virtual screening processes. Despite the development of numerous scoring functions in…

生物大分子 · 定量生物学 2024-01-22 Haoyu Lin , Shiwei Wang , Jintao Zhu , Yibo Li , Jianfeng Pei , Luhua Lai

In social networks, neighborhood is crucial for understanding individual behavior in response to environments, and thus it is essential to analyze an individual's local perspective within the global network. This paper studies how to…

统计方法学 · 统计学 2025-02-25 Lijia Wang , Xiao Han , Yanhui Wu , Y. X. Rachel Wang

Inference of the network structure (e.g., routing topology) and dynamics (e.g., link performance) is an essential component in many network design and management tasks. In this paper we propose a new, general framework for analyzing and…

网络与互联网体系结构 · 计算机科学 2019-11-13 Jian Ni , Sekhar Tatikonda

Comparative graph and network analysis play an important role in both systems biology and pattern recognition, but existing surveys on the topic have historically ignored or underserved one or the other of these fields. We present an…

社会与信息网络 · 计算机科学 2019-05-17 Emily Evans , Marissa Graham

Network alignment aims to find regions of topological or functional similarities between networks. In computational biology, it can be used to transfer biological knowledge from a well-studied species to a poorly-studied species between…

分子网络 · 定量生物学 2014-10-21 Joseph Crawford , Tijana Milenković

Social network alignment, aligning different social networks on their common users, is receiving dramatic attention from both academic and industry. All existing studies consider the social network to be static and neglect its inherent…

社会与信息网络 · 计算机科学 2019-11-04 Li Sun , Zhongbao Zhang , Pengxin Ji , Jian Wen , Sen Su , Philip S. Yu

Foundation models have impressive performance and generalization capabilities across a wide range of applications. The increasing size of the models introduces great challenges for the training. Tensor parallelism is a critical technique…

分布式、并行与集群计算 · 计算机科学 2023-01-23 Shenggan Cheng , Ziming Liu , Jiangsu Du , Yang You

Detecting dynamic patterns of task-specific responses shared across heterogeneous datasets is an essential and challenging problem in many scientific applications in medical science and neuroscience. In our motivating example of rodent…

神经元与认知 · 定量生物学 2024-07-02 Yubai Yuan , Babak Shahbaba , Norbert Fortin , Keiland Cooper , Qing Nie , Annie Qu

This paper introduces a novel computational approach for offloading sensor data processing tasks to servers in edge networks for better accuracy and makespan. A task is assigned with one of several offloading options, each comprises a…

网络与互联网体系结构 · 计算机科学 2025-05-05 Negar Erfaniantaghvayi , Zhongyuan Zhao , Kevin Chan , Ananthram Swami , Santiago Segarra

In this paper we describe SYNERGY, which is a highly parallelizable, linear planning system that is based on the genetic programming paradigm. Rather than reasoning about the world it is planning for, SYNERGY uses artificial selection,…

人工智能 · 计算机科学 2007-05-23 Ion Muslea

Detecting the interactions of genetic compounds like genes, SNPs, proteins, metabolites, etc. can potentially unravel the mechanisms behind complex traits and common genetic disorders. Several methods have been taken into consideration for…

计算工程、金融与科学 · 计算机科学 2015-05-26 Francesco Gadaleta

Self-organizing complex systems typically are comprised of a large number of frequently similar components or events. Through their process, a pattern at the global-level of a system emerges solely from numerous interactions among the…

人工智能 · 计算机科学 2007-05-23 Vitorino Ramos , Ajith Abraham

Low-rank and sparse composite approximation is a natural idea to compress Large Language Models (LLMs). However, such an idea faces two primary challenges that adversely affect the performance of existing methods. The first challenge…

机器学习 · 计算机科学 2026-02-27 Changhai Zhou , Qian Qiao , Yuhua Zhou , Yuxin Wu , Shichao Weng , Weizhong Zhang , Cheng Jin

Protein-protein interaction (PPI) network alignment is a canonical operation to transfer biological knowledge among species. The alignment of PPI-networks has many applications, such as the prediction of protein function, detection of…

分子网络 · 定量生物学 2019-05-15 Ehsan Kazemi , Matthias Grossglauser

The need for fast sparse optimization is emerging, e.g., to deal with large-dimensional data-driven problems and to track time-varying systems. In the framework of linear sparse optimization, the iterative shrinkage-thresholding algorithm…

最优化与控制 · 数学 2025-01-22 Vito Cerone , Sophie M. Fosson , Diego Regruto

This paper proposes a novel approach to solving nonlinear programming problems using a sharp augmented Lagrangian method with a smoothing technique. Traditional sharp augmented Lagrangian methods are known for their effectiveness but are…

最优化与控制 · 数学 2024-10-07 José Luis Romero , Damián Fernandez , Germán Ariel Torres

In this paper, we propose a quasi-Newton method for solving smooth and monotone nonlinear equations, including unconstrained minimization and minimax optimization as special cases. For the strongly monotone setting, we establish two global…

最优化与控制 · 数学 2024-10-04 Ruichen Jiang , Aryan Mokhtari