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Acquiring plausible pathways on high-dimensional structural distributions is beneficial in several domains. For example, in the drug discovery field, a protein conformational pathway, i.e. a highly probable sequence of protein structural…

Probabilistic Temporal Tensor Factorization (PTTF) is an effective algorithm to model the temporal tensor data. It leverages a time constraint to capture the evolving properties of tensor data. Nowadays the exploding dataset demands a large…

机器学习 · 统计学 2016-11-14 Guangxi Li , Zenglin Xu , Linnan Wang , Jinmian Ye , Irwin King , Michael Lyu

Motivation: Human cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome. In the case of oncogenes, recent theory suggests that there are only a few key "driver" mutations responsible…

基因组学 · 定量生物学 2013-07-16 Gregory Ryslik , Yuwei Cheng , Kei-Hoi Cheung , Yorgo Modis , Hongyu Zhao

Co-clustering simultaneously clusters rows and columns, revealing more fine-grained groups. However, existing co-clustering methods suffer from poor scalability and cannot handle large-scale data. This paper presents a novel and scalable…

分布式、并行与集群计算 · 计算机科学 2025-03-20 Zihan Wu , Zhaoke Huang , Hong Yan

A method to search for local structural similarities in proteins at atomic resolution is presented. It is demonstrated that a huge amount of structural data can be handled within a reasonable CPU time by using a conventional relational…

生物大分子 · 定量生物学 2007-12-28 Akira R. Kinjo , Haruki Nakamura

We consider the certification of temporal quantum correlations using the pseudo-density matrix (PDM), an extension of the density matrix to the time domain, where negative eigenvalues are key indicators of temporal correlations.…

量子物理 · 物理学 2025-04-25 Hongfeng Liu , Zhenhuan Liu , Shu Chen , Xinfang Nie , Xiangjing Liu , Dawei Lu

To effectively analyze and design cyberphysical systems (CPS), designers today have to combat the data deluge problem, i.e., the burden of processing intractably large amounts of data produced by complex models and experiments. In this…

机器学习 · 计算机科学 2017-05-17 Marcell Vazquez-Chanlatte , Jyotirmoy V. Deshmukh , Xiaoqing Jin , Sanjit A. Seshia

Adapted from biological sequence alignment, trace alignment is a process mining technique used to visualize and analyze workflow data. Any analysis done with this method, however, is affected by the alignment quality. The best existing…

数据结构与算法 · 计算机科学 2017-09-19 Shuhong Chen , Sen Yang , Moliang Zhou , Randall S. Burd , Ivan Marsic

Circadian rhythms regulate the physiology and behavior of humans and animals. Despite advancements in understanding these rhythms and predicting circadian phases at the transcriptional level, predicting circadian phases from proteomic data…

机器学习 · 计算机科学 2025-01-14 Aram Ansary Ogholbake , Qiang Cheng

Electronic records contain sequences of events, some of which take place all at once in a single visit, and others that are dispersed over multiple visits, each with a different timestamp. We postulate that fine temporal detail, e.g.,…

机器学习 · 计算机科学 2019-04-30 Mohammad Taha Bahadori , Zachary Chase Lipton

The analysis of data streams has received considerable attention over the past few decades due to sensors, social media, etc. It aims to recognize patterns in an unordered, infinite, and evolving stream of observations. Clustering this type…

机器学习 · 计算机科学 2022-01-14 Mohammed Oualid Attaoui , Hanene Azzag , Mustapha Lebbah , Nabil Keskes

Sequential pattern mining (SPM) is an important technique of pattern mining, which has many applications in reality. Although many efficient sequential pattern mining algorithms have been proposed, there are few studies can focus on target…

数据库 · 计算机科学 2022-03-01 Gengsen Huang , Wensheng Gan , Philip S. Yu

This paper reports on ongoing research investigating more expressive approaches to spatial-temporal trajectory clustering. Spatial-temporal data is increasingly becoming universal as a result of widespread use of GPS and mobile devices,…

数据库 · 计算机科学 2017-12-12 Ivens Portugal , Paulo Alencar , Donald Cowan

We study the problem of clustering sequences of unlabeled point sets taken from a common metric space. Such scenarios arise naturally in applications where a system or process is observed in distinct time intervals, such as biological…

数据结构与算法 · 计算机科学 2017-10-17 Tamal K. Dey , Alfred Rossi , Anastasios Sidiropoulos

Mining Time Series data has a tremendous growth of interest in today's world. To provide an indication various implementations are studied and summarized to identify the different problems in existing applications. Clustering time series is…

信息检索 · 计算机科学 2010-05-25 V. Kavitha , M. Punithavalli

Recently there has been an increase in the studies on time-series data mining specifically time-series clustering due to the vast existence of time-series in various domains. The large volume of data in the form of time-series makes it…

机器学习 · 计算机科学 2019-12-06 Hossein Kamalzadeh , Abbas Ahmadi , Saeed Mansour

Mass spectrometry based clinical proteomics has emerged as a powerful tool for highthroughput protein profiling and biomarker discovery. Recent improvements in mass spectrometry technology have boosted the potential of proteomic studies in…

统计方法学 · 统计学 2016-02-10 Alexia Kakourou , Werner Vach , Simone Nicolardi , Yuri van der Burgt , Bart Mertens

Networks are used as highly expressive tools in different disciplines. In recent years, the analysis and mining of temporal networks have attracted substantial attention. Frequent pattern mining is considered an essential task in the…

社会与信息网络 · 计算机科学 2021-05-14 Ali Jazayeri , Christopher C. Yang

A wide range of data that appear in scientific experiments and simulations are multivariate or multifield in nature, consisting of multiple scalar fields. Topological feature search of such data aims to reveal important properties useful to…

计算几何 · 计算机科学 2024-06-06 Tripti Agarwal , Amit Chattopadhyay , Vijay Natarajan

Massive volumes of high-dimensional data that evolves over time is continuously collected by contemporary information processing systems, which brings up the problem of organizing this data into clusters, i.e. achieve the purpose of…

机器学习 · 计算机科学 2019-10-22 Di Xu , Tianhang Long , Junbin Gao