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Creating a quantitative theory for the cortex presents challenges and raises questions. What are the significant scales--micro, meso, or macroscopic? What are the interactions--pairwise, higher order, or mean-field? And what control…

神经元与认知 · 定量生物学 2025-05-29 Nima Dehghani

Purpose: Research into epileptic networks has recently allowed deeper insights into the epileptic process. Here we investigated the importance of individual network nodes for seizure dynamics. Methods: We analysed intracranial…

神经元与认知 · 定量生物学 2014-12-03 Christian Geier , Stephan Bialonski , Christian E. Elger , Klaus Lehnertz

Understanding how the brain switches from normal activity to an epileptic seizure is essential for improving seizure therapy, yet the underlying mechanisms remain largely unknown. In particular, seizure onset can be described as a critical…

This chapter first presents a rather personal view of some different aspects of predictability, going in crescendo from simple linear systems to high-dimensional nonlinear systems with stochastic forcing, which exhibit emergent properties…

地球物理 · 物理学 2014-08-26 Didier Sornette , Ivan Osorio

Temporal correlations in the brain are thought to have very dichotomic roles. On one hand they are ubiquitously present in the healthy brain and are thought to underlie feature binding during information processing. On the other hand large…

生物物理 · 物理学 2009-11-10 Bethany Percha , Rhonda Dzakpasu , Michał Żochowski

It is well known that the addition of noise in a multistable system can induce random transitions between stable states. The rate of transition can be characterised in terms of the noise-free system's dynamics and the added noise: for…

动力系统 · 数学 2017-05-25 Jennifer Creaser , Krasimira Tsaneva-Atanasova , Peter Ashwin

Epilepsy which is characterized by seizures is studied using EEG signals by recording the electrical activity of the brain. Different types of communication between different parts of the brain are characterized by many state of the art…

机器学习 · 计算机科学 2020-09-29 Mohammad Mansour , Fouad Khnaisser , Hmayag Partamian

Epilepsy is a disorder characterised by spontaneous, recurrent seizures. Both local and network abnormalities have been associated with epilepsy, and the exact processes generating seizures are thought to be heterogeneous and…

神经元与认知 · 定量生物学 2019-01-07 Yujiang Wang , Gabrielle Marie Schroeder , Nishant Sinha , Peter Neal Taylor

This review provides a dynamical systems perspective on psychiatric symptoms and disease, and discusses its potential implications for diagnosis, prognosis, and treatment. After a brief introduction into the theory of dynamical systems, we…

神经元与认知 · 定量生物学 2018-09-18 Daniel Durstewitz , Quentin J. M. Huys , Georgia Koppe

Chimera states---the coexistence of synchrony and asynchrony in a nonlocally-coupled network of identical oscillators---are often used as a model framework for epileptic seizures. Here, we explore the dynamics of chimera states in a network…

神经元与认知 · 定量生物学 2020-12-02 Henry M. Mitchell , Peter Sheridan Dodds , J. Matthew Mahoney , Christopher M. Danforth

Epilepsy is a well-known neuronal disorder that can be identified by interpretation of the electroencephalogram (EEG) signal. Usually, the length of an EEG signal is quite long which is challenging to interpret manually. In this work, we…

机器学习 · 计算机科学 2019-03-07 Md Mursalin , Syed Shamsul Islam , Md Kislu Noman , Adel Ali Al-Jumaily

In clinical neuroscience, epileptic seizures have been associated with the sudden emergence of coupled activity across the brain. The resulting functional networks - in which edges indicate strong enough coupling between brain regions - are…

应用统计 · 统计学 2021-02-25 Xiaojing Zhu , Heather Shappell , Mark A. Kramer , Catherine J. Chu , Eric D. Kolaczyk

One of epileptology's fundamental aims is the formulation of a universal, internally consistent seizure definition. To assess this aim's feasibility, three signal analysis methods were applied to a seizure time series and performance…

神经元与认知 · 定量生物学 2011-11-15 Ivan Osorio , Alexey Lyubushin , Didier Sornette

Seizure and synchronization are related to each other in complex manner. Altered synchrony has been implicated in loss of consciousness during partial seizures. However, the mechanism of altered consciousness following termination of…

神经元与认知 · 定量生物学 2018-01-30 Puneet Dheer , Sandipan Pati , Srinath Jayachandran , Kaushik Kumar Majumdar

The electroencephalographic (EEG) data intracerebrally recorded from 20 epileptic humans with different brain origins of focal epilepsies or types of seizures, ages and sexes are investigated (nearly 700 million data). Multi channel…

生物物理 · 物理学 2010-02-19 Caglar Tuncay

Bursting neurons are considered to be a potential cause of over-excitability and seizure susceptibility. The functional influence of these neurons in extended epileptic networks is still poorly understood. There is mounting evidence that…

神经元与认知 · 定量生物学 2016-10-07 Christian Geier , Alexander Rothkegel , Christian E. Elger , Klaus Lehnertz

Neural network oscillations are a fundamental mechanism for cognition, perception and consciousness. Consequently, perturbations of network activity play an important role in the pathophysiology of brain disorders. When structural…

神经元与认知 · 定量生物学 2016-04-29 Timothée Proix , Fabrice Bartolomei , Maxime Guye , Viktor K. Jirsa

Epileptic biomarkers play a crucial role in identifying the origin of seizures, an essential aspect of pre-surgical planning for epilepsy treatment. These biomarkers can vary significantly over time. By studying these temporal fluctuations,…

信号处理 · 电气工程与系统科学 2025-11-11 Mehdi Zekriyapanah Gashti , Mostafa Mohammadpour , Hassan Eshkiki , Vahid Ghanbarizadeh

We propose a novel Coupled Hidden Markov Model to detect epileptic seizures in multichannel electroencephalography (EEG) data. Our model defines a network of seizure propagation paths to capture both the temporal and spatial evolution of…

信号处理 · 电气工程与系统科学 2018-08-13 Jeff Craley , Emily Johnson , Archana Venkataraman

Electroencephalography (EEG), as the most common tool for epileptic seizure classification, contains useful information about different physiological states of the brain. Seizure related features in EEG signals can be better identified when…

信号处理 · 电气工程与系统科学 2018-05-15 Amirmasoud Ahmadi , Vahid Shalchyan , Mohammad Reza Daliri