相关论文: Asymptotic and bifurcation analysis of wave-pinnin…
We study the mass-conserved reaction-diffusion system known as the wave-pinning model, which serves as a minimal framework for describing cell polarity. In this model, the interplay between reaction kinetics and slow diffusion forms a sharp…
A system of two Schnakenberg-like reaction-diffusion equations is investigated analytically and numerically. The system has previously been used as a minimal model for concentrations of GTPases involved in the process of cell polarisation.…
The bulk-surface wave pinning model is a reaction-diffusion system for studying cell polarisation. It is constituted by a surface reaction-diffusion equation, coupled to a bulk diffusion equation with a non-linear boundary condition. Cell…
We revisit the problem of pinning a reaction-diffusion front by a defect, in particular by a reaction-free region. Using collective variables for the front and numerical simulations, we compare the behaviors of a bistable and monostable…
Eukaryotic cells demonstrate a wide variety of dynamic patterns of filamentous actin (F-actin) and its regulators. Some of these patterns play important roles in cell functions, such as distinct motility modes, which motivate this study. We…
We consider spatially discrete bistable reaction-diffusion equations that admit wave front solutions. Depending on the parameters involved, such wave fronts appear to be pinned or to glide at a certain speed. We study the transition of…
Several cellular activities, such as directed cell migration, are coordinated by an intricate network of biochemical reactions which lead to a polarised state of the cell, in which cellular symmetry is broken, causing the cell to have a…
We investigate the oscillatory dynamics and bifurcation structure of a reaction-diffusion system with bistable nonlinearity and mass conservation, which was proposed by [Otsuji et al, PLoS Comp. Biol. 3 (2007), e108]. The system is a useful…
Some dividing cells sense their shape by becoming polarized along their long axis. Cell polarity is controlled in part by polarity proteins like Rho GTPases cycling between active membrane-bound forms and inactive cytosolic forms, modeled…
Cued and un-cued cell polarization is a fundamental mechanism in cell biology. As an alternative to the classical Turing bifurcation, it has been proposed that the cell polarity might onset by means of the well-known phenomenon of…
We propose a model for cell polarization as a response to an external signal which results in a system of PDEs for different variants of a protein on the cell surface and interior respectively. We study stationary states of this model in…
Traveling fronts and stationary localized patterns in bistable reaction-diffusion systems have been broadly studied for classical continuous media and regular lattices. Analogs of such non-equilibrium patterns are also possible in networks.…
Cell polarization requires redistribution of specific proteins to the nascent front and back of a eukarytotic cell. Among these proteins are Rac and Rho, members of the small GTPase family that regulate the actin cytoskeleton. Rac promotes…
We study analytically and numerically a bistable reaction-diffusion equation on an arbitrary finite network. We prove that stable fixed points (multi-fronts) exist for any configuration as long as the diffusion is small. We also study fold…
Fronts propagating in two-dimensional advection-reaction-diffusion (ARD) systems exhibit rich topological structure. When the underlying fluid flow is periodic in space and time, the reaction front can lock to the driving frequency. We…
This paper studies a bulk-surface reaction-diffusion system for cell polarization in two-dimensional domains. The model describes the formation of localized patterns through the wave-pinning mechanism, while explicitly incorporating the…
We describe various types of traveling fronts of bistable reaction-diffusion cellular automata. These dynamical systems with discrete time, space, and state spaces can be seen as fully discrete versions of widely studied bistable…
We study invasion fronts and spreading speeds in two component reaction-diffusion systems. Using a variation of Lin's method, we construct traveling front solutions and show the existence of a bifurcation to locked fronts where both…
Reaction-diffusion systems have been widely used to study spatio-temporal phenomena in cell biology, such as cell polarization. Coupled bulk-surface models naturally include compartmentalization of cytosolic and membrane-bound polarity…
Cellular differentiation in a developping organism is studied via a discrete bistable reaction-diffusion model. A system of undifferentiated cells is allowed to receive an inductive signal emenating from its environment. Depending on the…