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Converging evidence indicates that the heterogeneity of cognitive profiles may arise through detectable alternations in brain functions. Particularly, brain functional connectivity, measured under resting and cognitive states, characterizes…

应用统计 · 统计学 2023-02-22 Tianqi Chen , Chichun Tan , Hongyu Zhao , Todd Constable , Sarah Yip , Yize Zhao

Reducing the number of false discoveries is presently one of the most pressing issues in the life sciences. It is of especially great importance for many applications in neuroimaging and genomics, where datasets are typically…

统计方法学 · 统计学 2018-06-26 Alexej Gossmann , Pascal Zille , Vince Calhoun , Yu-Ping Wang

Whole-brain network analyses remain the vanguard in neuroimaging research, coming to prominence within the last decade. Network science approaches have facilitated these analyses and allowed examining the brain as an integrated system.…

应用统计 · 统计学 2015-05-04 Sean L. Simpson , Paul J. Laurienti

The use of EEG biometrics, for the purpose of automatic people recognition, has received increasing attention in the recent years. Most of current analysis rely on the extraction of features characterizing the activity of single brain…

Traditional causal connectivity methods in task-based and resting-state functional magnetic resonance imaging (fMRI) face challenges in accurately capturing directed information flow due to their sensitivity to noise and inability to model…

神经元与认知 · 定量生物学 2025-04-03 Boseong Kim , Debashis Das Chakladar , Haejun Chung , Ikbeom Jang

Random Field Theory has been used in the fMRI literature to address the multiple comparisons problem. The method provides an analytical solution for the computation of precise p-values when its assumptions are met. When its assumptions are…

应用统计 · 统计学 2016-07-28 Tim M. Tierney , Christopher A. Clark , David W. Carmichael

The estimation of functional networks through functional covariance and graphical models have recently attracted increasing attention in settings with high dimensional functional data, where the number of functional variables p is…

统计理论 · 数学 2024-09-05 Qin Fang , Qing Jiang , Xinghao Qiao

We discuss observational studies that test many causal hypotheses, either hypotheses about many outcomes or many treatments. To be credible an observational study that tests many causal hypotheses must demonstrate that its conclusions are…

统计方法学 · 统计学 2017-03-08 Qingyuan Zhao , Dylan S. Small , Paul R. Rosenbaum

Inverse inference, or "brain reading", is a recent paradigm for analyzing functional magnetic resonance imaging (fMRI) data, based on pattern recognition and statistical learning. By predicting some cognitive variables related to brain…

We consider functional linear regression models where functional outcomes are associated with scalar predictors by coefficient functions with shape constraints, such as monotonicity and convexity, that apply to sub-domains of interest. To…

统计方法学 · 统计学 2025-05-09 Kyunghee Han , Yeonjoo Park , Soo-Young Kim

Traditional functional connectivity based on functional magnetic resonance imaging (fMRI) can only capture pairwise interactions between brain regions. Hypergraphs, which reveal high-order relationships among multiple brain regions, have…

神经元与认知 · 定量生物学 2025-05-20 Wenqi Hu , Xuerui Su , Guanliang Li , Yidi Pan , Aijing Lin

Covariate adjustment is widely recommended to improve statistical efficiency in randomized clinical trials (RCTs), yet empirical evidence comparing available strategies remains limited. This lack of real-world evaluation leaves unresolved…

应用统计 · 统计学 2026-02-03 Yulin Shao , Liangbo Lyu , Menggang Yu , Bingkai Wang

Clustering analysis is one of the most widely used statistical tools in many emerging areas such as microarray data analysis. For microarray and other high-dimensional data, the presence of many noise variables may mask underlying…

机器学习 · 统计学 2008-03-26 Benhuai Xie , Wei Pan , Xiaotong Shen

In covariate-adaptive or response-adaptive randomization, the treatment assignment and outcome can be correlated. Under this situation, re-randomization tests are a straightforward and attractive method to provide valid statistical…

统计方法学 · 统计学 2023-03-14 Yilong Zhang , Yujie Zhao , Yiwen Luo

Deducing the structure of neural circuits is one of the central problems of modern neuroscience. Recently-introduced calcium fluorescent imaging methods permit experimentalists to observe network activity in large populations of neurons,…

应用统计 · 统计学 2011-07-22 Yuriy Mishchencko , Joshua T. Vogelstein , Liam Paninski

Familywise error rate (FWER) has been a cornerstone in simultaneous inference for decades, and the classical Bonferroni method has been one of the most prominent frequentist approaches for controlling FWER. The present article studies the…

统计理论 · 数学 2021-12-07 Monitirtha Dey , Subir Kumar Bhandari

Graph structure learning aims to learn connectivity in a graph from data. It is particularly important for many computer vision related tasks since no explicit graph structure is available for images for most cases. A natural way to…

计算机视觉与模式识别 · 计算机科学 2022-12-26 Yaohua Wang , FangYi Zhang , Ming Lin , Senzhang Wang , Xiuyu Sun , Rong Jin

The characterisation of the brain as a "connectome", in which the connections are represented by correlational values across timeseries and as summary measures derived from graph theory analyses, has been very popular in the last years.…

机器学习 · 计算机科学 2020-03-13 Tiago Azevedo , Luca Passamonti , Pietro Liò , Nicola Toschi

Action, cognition, emotion and perception can be mapped in the brain by using set of techniques. Translating unimodal concepts from one modality to another is an important step towards understanding the neural mechanisms. This paper…

其他计算机科学 · 计算机科学 2012-12-18 Revati Shriram , Dr. M. Sundhararajan , Nivedita Daimiwal

Brain regions are often topographically connected: nearby locations within one brain area connect with nearby locations in another area. Mapping these connection topographies, or 'connectopies' in short, is crucial for understanding how…

定量方法 · 定量生物学 2017-07-18 Koen V. Haak , Andre F. Marquand , Christian F. Beckmann