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Computational modeling is becoming a widely used methodology in modern neuroscience. However, as the complexity of the phenomena under study increases, the analysis of the results emerging from the simulations concomitantly becomes more…

神经元与认知 · 定量生物学 2020-03-16 Sergio E. Galindo , Pablo Toharia , Oscar D. Robles , Eduardo Ros , Luis Pastor , Jesús A. Garrido

Network control theory has recently emerged as a promising approach for understanding brain function and dynamics. By operationalizing notions of control theory for brain networks, it offers a fundamental explanation for how brain dynamics…

定量方法 · 定量生物学 2020-03-20 Shikuang Deng , Shi Gu

Regulatory networks describe the interactions between molecular or cellular regulators, like transcription factors and genes in gene regulatory networks, kinases and their receptors in signalling networks, or neurons in neural networks. A…

分子网络 · 定量生物学 2022-12-29 Niklas Bonacker , Johannes Berg

Inhibitory interneurons, ubiquitous in the central nervous system, form networks connected through both chemical synapses and gap junctions. These networks are essential for regulating the activity of principal neurons, especially by…

神经元与认知 · 定量生物学 2025-05-09 Hélène Todd , Mathieu Desroches , Alex Cayco-Gajic , Boris Gutkin

The characterization of coordinated activity in neuronal populations has received renewed interest in the light of advancing experimental techniques which allow recordings from multiple units simultaneously. Across both in vitro and in vivo…

神经元与认知 · 定量生物学 2015-06-16 Feraz Azhar , William S. Anderson

Periodic pulse train stimulation is generically used to study the function of the nervous system and to counteract disease-related neuronal activity, e.g., collective periodic neuronal oscillations. The efficient control of neuronal…

适应与自组织系统 · 物理学 2020-08-05 Kestutis Pyragas , Augustinas P. Fedaravičius , Tatjana Pyragienė

Understanding how the brain learns to compute functions reliably, efficiently and robustly with noisy spiking activity is a fundamental challenge in neuroscience. Most sensory and motor tasks can be described as dynamical systems and could…

神经元与认知 · 定量生物学 2017-05-24 Sophie Denève , Alireza Alemi , Ralph Bourdoukan

Connectomics and network neuroscience offer quantitative scientific frameworks for modeling and analyzing networks of structurally and functionally interacting neurons, neuronal populations, and macroscopic brain areas. This shift in…

神经元与认知 · 定量生物学 2020-10-06 Richard Betzel

We study a rate-model neural network composed of excitatory and inhibitory neurons in which neuronal input-output functions are power laws with a power greater than 1, as observed in primary visual cortex. This supralinear input-output…

神经元与认知 · 定量生物学 2015-03-20 Yashar Ahmadian , Daniel B. Rubin , Kenneth D. Miller

There is growing interest in understanding how the structural interconnections among brain regions change with the occurrence of neurological diseases. Diffusion weighted MRI imaging has allowed researchers to non-invasively estimate a…

应用统计 · 统计学 2015-10-20 Daniele Durante , Madelaine Daianu , Neda Jahanshad , Paul M. Thompson , David B. Dunson

Cumulative cultural evolution occurs when adaptive innovations are passed down to consecutive generations through social learning. This process has shaped human technological innovation, but also occurs in non-human species. While it is…

种群与进化 · 定量生物学 2023-07-26 Edwin S. Dalmaijer

We study a standard linear readout model of perceptual integration from a population of sensory neurons. We show that the readout can be associated to a set of characteristic equations which summarize the joint trial-to-trial covariance…

神经元与认知 · 定量生物学 2013-03-11 Adrien Wohrer , Christian K. Machens

Few studies that examine the neurogenesis--behaviour relationship formally establish covariation between neurogenesis and behaviour or rule out competing explanations. The behavioural relevance of neurogenesis might therefore be…

神经元与认知 · 定量生物学 2015-06-19 Stanley E. Lazic , Johannes Fuss , Peter Gass

The neural mechanism of memory has a very close relation with the problem of representation in artificial intelligence. In this paper a computational model was proposed to simulate the network of neurons in brain and how they process…

神经元与认知 · 定量生物学 2020-12-02 Hui Wei

Cells and tissues exert forces and can actively change shape. This strikingly autonomous behavior is powered by the cytoskeleton, which includes an active gel of actin filaments, crosslinks, and myosin molecular motors. Although individual…

软凝聚态物质 · 物理学 2017-07-26 José Alvarado , Misha Sheinman , Abhinav Sharma , Fred C. MacKintosh , Gijsje H. Koenderink

Neurons can code for multiple variables simultaneously and neuroscientists are often interested in classifying neurons based on their receptive field properties. Statistical models provide powerful tools for determining the factors…

神经元与认知 · 定量生物学 2022-10-28 Mehrad Sarmashghi , Shantanu P. Jadhav , Uri T. Eden

Most nervous systems encode information about stimuli in the responding activity of large neuronal networks. This activity often manifests itself as dynamically coordinated sequences of action potentials. Since multiple electrode recordings…

神经元与认知 · 定量生物学 2011-11-09 Kristina Lisa Klinkner , Cosma Rohilla Shalizi , Marcelo F. Camperi

The activity of a neural network is defined by patterns of spiking and silence from the individual neurons. Because spikes are (relatively) sparse, patterns of activity with increasing numbers of spikes are less probable, but with more…

神经元与认知 · 定量生物学 2025-02-13 Gasper Tkacik , Thierry Mora , Olivier Marre , Dario Amodei , Michael J. Berry , William Bialek

Social connectivity is the key process that characterizes the structural properties of social networks and in turn processes such as navigation, influence or information diffusion. Since time, attention and cognition are inelastic…

物理与社会 · 物理学 2013-04-09 Giovanna Miritello , Rubén Lara , Manuel Cebrián , Esteban Moro

Finding the common structural brain connectivity network for a given population is an open problem, crucial for current neuro-science. Recent evidence suggests there's a tightly connected network shared between humans. Obtaining this…

神经元与认知 · 定量生物学 2017-01-10 Nahuel Lascano , Guillermo Gallardo , Rachid Deriche , Dorian Mazauric , Demian Wassermann