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相关论文: Global Alignment of Molecular Sequences via Ancest…

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Phylogenetic inference, the task of reconstructing how related sequences evolved from common ancestors, is a central objective in evolutionary genomics. The current state-of-the-art methods exploit probabilistic models of sequence evolution…

种群与进化 · 定量生物学 2026-02-19 Luc Blassel , Noémie Sauvage , Pierre Barrat-Charlaix , Bastien Boussau , Nicolas Lartillot , Laurent Jacob

In this paper, we consider the problem of reconstructing trees from traces in the tree edit distance model. Previous work by Davies et al. (2019) analyzed special cases of reconstructing labeled trees. In this work, we significantly expand…

计算复杂性 · 计算机科学 2022-01-14 Thomas Maranzatto

Inducing latent tree structures from sequential data is an emerging trend in the NLP research landscape today, largely popularized by recent methods such as Gumbel LSTM and Ordered Neurons (ON-LSTM). This paper proposes FASTTREES, a new…

计算与语言 · 计算机科学 2021-11-30 Bill Tuck Weng Pung , Alvin Chan

The supertree construction problem is about combining several phylogenetic trees with possibly conflicting information into a single tree that has all the leaves of the source trees as its leaves and the relationships between the leaves are…

计算工程、金融与科学 · 计算机科学 2020-02-19 Laura Koponen , Emilia Oikarinen , Tomi Janhunen , Laura Säilä

In creating sentence embeddings for Natural Language Inference (NLI) tasks, using transformer-based models like BERT leads to high accuracy, but require hundreds of millions of parameters. These models take in sentences as a sequence of…

计算与语言 · 计算机科学 2025-12-17 Jason Lunder

Sequences of nucleotides (for DNA and RNA) or amino acids (for proteins) are central objects in biology. Among the most important computational problems is that of sequence alignment, i.e. arranging sequences from different organisms in…

定量方法 · 定量生物学 2020-12-08 Anna Paola Muntoni , Andrea Pagnani , Martin Weigt , Francesco Zamponi

A branching random tessellation (BRT) is a stochastic process that transforms a coarse initial tessellation of $\mathbb{R}^d$ into a finer tessellation by means of random cell divisions in continuous time. This concept generalises the…

概率论 · 数学 2015-09-10 Hans-Otto Georgii , Tomasz Schreiber , Christoph Thäle

Phylogenetic networks are a generalization of phylogenetic trees to leaf-labeled directed acyclic graphs that represent ancestral relationships between species whose past includes non-tree-like events such as hybridization and horizontal…

组合数学 · 数学 2021-04-13 Janosch Döcker , Simone Linz , Charles Semple

In the field of chemistry, there have been many attempts to predict the properties of unknown compounds from statistical models constructed using machine learning. In an area where many known compounds are present (the interpolation area),…

机器学习 · 计算机科学 2020-09-22 Kohei Numata , Kenichi Tanaka

We present an algorithm for learning decision trees using stochastic gradient information as the source of supervision. In contrast to previous approaches to gradient-based tree learning, our method operates in the incremental learning…

机器学习 · 统计学 2019-09-25 Henry Gouk , Bernhard Pfahringer , Eibe Frank

We present methods for repairing traces against specifications given as temporal behavior trees (TBT). TBT are a specification formalism for action sequences in robotics and cyber-physical systems, where specifications of sub-behaviors,…

计算机科学中的逻辑 · 计算机科学 2026-04-21 Sebastian Schirmer , Philipp Schitz , Johann C. Dauer , Bernd Finkbeiner , Sriram Sankaranarayanan

Understanding the evolution of a set of genes or species is a fundamental problem in evolutionary biology. The problem we study here takes as input a set of trees describing {possibly discordant} evolutionary scenarios for a given set of…

数据结构与算法 · 计算机科学 2019-07-10 Cedric Chauve , Mark Jones , Manuel Lafond , Céline Scornavacca , Mathias Weller

We seek to automate the design of molecules based on specific chemical properties. In computational terms, this task involves continuous embedding and generation of molecular graphs. Our primary contribution is the direct realization of…

机器学习 · 计算机科学 2019-04-01 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Phylogenetic networks are leaf-labelled directed acyclic graphs that are used to describe non-treelike evolutionary histories and are thus a generalization of phylogenetic trees. The hybridization number of a phylogenetic network is the sum…

数据结构与算法 · 计算机科学 2016-06-01 Leo van Iersel , Steven Kelk , Nela Lekić , Chris Whidden , Norbert Zeh

Phylogenomics, even more so than traditional phylogenetics, needs to represent the uncertainty in evolutionary trees due to systematic error. Here we illustrate the analysis of genome-scale alignments of yeast, using robust measures of the…

种群与进化 · 定量生物学 2009-12-31 Peter J. Waddell , Ariful Azad

Substring kernels are classical tools for representing biological sequences or text. However, when large amounts of annotated data are available, models that allow end-to-end training such as neural networks are often preferred. Links…

机器学习 · 统计学 2019-10-18 Dexiong Chen , Laurent Jacob , Julien Mairal

The reconstruction of the history of evolutionary genome-wide events among a set of related organisms is of great biological interest. A simplified model that captures only content modifying operations was introduced recently. It allows the…

组合数学 · 数学 2012-08-15 Stefan Canzar , Sandro Andreotti

We observe $n$ sequences at each of $m$ sites, and assume that they have evolved from an ancestral sequence that forms the root of a binary tree of known topology and branch lengths, but the sequence states at internal nodes are unknown.…

统计计算 · 统计学 2014-08-28 Adam Persing , Ajay Jasra , Alexandros Beskos , David Balding , Maria De Iorio

Evolutionary events such as incomplete lineage sorting and lateral gene transfer constitute major problems for inferring species trees from gene trees, as they can sometimes lead to gene trees which conflict with the underlying species…

种群与进化 · 定量生物学 2013-04-23 Andreas Sand , Mike Steel

Generative models reliant on sequential autoregression have been at the forefront of language generation for an extensive period, particularly following the introduction of widely acclaimed transformers. Despite its excellent performance,…

计算与语言 · 计算机科学 2024-06-21 Yaguang Li , Xin Chen