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A Trojan-horse strategy for cancer therapy employing tumor-tropic mesenchymal stem cells transfected with a non-viral nanovector is here presented. In this sense, ultrasound-responsive mesoporous silica nanoparticles were coated with a…

组织与器官 · 定量生物学 2021-03-17 Juan L. Paris , Paz de la Torre , M. Victoria Cabanas , Miguel Manzano , Ana I. Flores , Maria Vallet-Regi

A series of 32 green tea leaves samples from different Asian producers were analyzed by direct {\gamma}-ray spectrometry at the PRISNA facility in Bordeaux. All the samples contain about 500 Bq/kg of 40K and 10 Bq/kg of 210Pb. As expected,…

科普物理 · 物理学 2018-06-27 M. S. Pravikoff , Ph. Hubert , H. Ohsumi

Bremsstrahlung photon beams produced by medical linear accelerators are currently the most commonly used method of radiation therapy for cancerous tumors. Photons with energies greater than 8-10 MeV potentially generate neutrons through…

加速器物理 · 物理学 2013-07-11 Danial Salehi , M. Salehi Jozani , Dariush Sardari

Proton beam therapy can potentially offer improved treatment for cancers of the head and neck and in paediatric patients. There has been a sharp uptake of proton beam therapy in recent years as improved delivery techniques and patient…

In this paper we consider chemotherapy in a spatial model of tumor growth. The model, which is of reaction-diffusion type, takes into account the complex interactions between the tumor and surrounding stromal cells by including densities of…

Tomographic imaging with radionuclides commonly used in nuclear medicine, such as $^{111}$In (171 and 245 keV) and $^{131}$I (364 keV), is in high demand for medical applications and small animal imaging. The Si/CdTe Compton camera with its…

Ion beam therapy has become a frequently applied form of cancer therapy over the last years. The advantage of ion beam therapy over conventional radiotherapy using photons is the strongly localized dose deposition, leading to a reduction of…

仪器与探测器 · 物理学 2020-07-28 F. Ulrich-Pur , T. Bergauer , A. Burker , S. Hatamikia , A. Hirtl , C. Irmler , S. Kaser , P. Paulitsch , F. Pitters , V. Teufelhart

The thick-target ISOL (Isotope mass Separation OnLine) method provides beams of more than 1000 radionuclides of 74 elements. The method is well established for elements with sufficiently high volatility at ca. 2000 {\deg}C. To extract…

Effective education in radiotherapy plan quality review requires a robust, regularly updated set of examples and the flexibility to demonstrate multiple possible planning approaches and their consequences. However, the current clinic-based…

Radiotherapy aims to deliver a prescribed dose to the tumor while sparing neighboring organs at risk (OARs). Increasingly complex treatment techniques such as volumetric modulated arc therapy (VMAT), stereotactic radiosurgery (SRS),…

医学物理 · 物理学 2023-10-23 Elahheh Salari , Jing Wang , Jacob Wynne , Chih-Wei Chang , Xiaofeng Yang

Radiation therapy aims to deliver the prescribed amount of dose to a tumour at the same time as sparing the surrounding tissues as much as possible. In charged particle therapy, delivering the prescribed dose is equivalent to delivering the…

医学物理 · 物理学 2018-03-05 Simona Giordanengo , Marco Donetti

The performance of the energy degrader in terms of beam properties directly impacts the design and cost of cyclotron-based proton therapy centers. The aim of this study is to evaluate the performances of different existing and novel…

Chemotherapy for cancer treatment is costly and accompanied by severe side effects, highlighting the critical need for early prediction of treatment outcomes to improve patient management and informed decision-making. Predictive models for…

Given that there are 94 clinics and more than 200,000 patients treated worldwide, proton and carbon are the most used heavily charged particles in heavy ion therapy. However, there is a recent increasing trend in using new ion beams. Each…

医学物理 · 物理学 2021-01-26 Fatih Ekinci , Erkan Bostanci , Ozlem Dagli , Mehmet Serdar Guzel

Extraction of the light weight radioisotopes (LWR) 89Sr/90Sr, from the expended nuclear bars in the Fukushima reactor, should have decreased the extent of contamination during the course of the accident. 89Sr applications could pay for the…

综合物理 · 物理学 2012-08-20 Alfred Bennun

In the space environment, instruments onboard of spacecrafts can be affected by displacement damage due to radiation. The differential scattering cross section for screened nucleus--nucleus interactions - i.e., including the effects due to…

Radiotherapy treatment for prostate cancer relies on computed tomography (CT) and/or magnetic resonance imaging (MRI) for segmentation of target volumes and organs at risk (OARs). Manual segmentation of these volumes is regarded as the gold…

FLASH radiotherapy (FLASH-RT) has shown the potential to spare normal tissue while seemingly maintaining the effectiveness of conventional radiotherapy (CONV-RT). It has been suggested that the protective effect arises from the radiolytic…

Purpose:Chest X-ray (CXR) is an essential tool and one of the most prescribed imaging to detect pulmonary abnormalities, with a yearly estimate of over 2 billion imaging performed worldwide. However, the accurate and timely diagnosis of TB…

计算机视觉与模式识别 · 计算机科学 2023-07-28 Subhankar Chattoraj , Bhargava Reddy , Manoj Tadepalli , Preetham Putha

Chemotherapy is one of the most important therapeutic options used to treat human cancers, either alone or in combination with radiation therapy and surgery. Recent studies have indicated that intra-tumoural heterogeneity has a significant…

组织与器官 · 定量生物学 2014-07-04 Gibin G Powathil , Mark AJ Chaplain , Maciej Swat