相关论文: Gene ranking and biomarker discovery under correla…

Gene expression datasets are usually of high dimensionality and therefore require efficient and effective methods for identifying the relative importance of their attributes. Due to the huge size of the search space of the possible…

This paper proposes integrating semantics-oriented similarity representation into RankingMatch, a recently proposed semi-supervised learning method. Our method, dubbed ReRankMatch, aims to deal with the case in which labeled and unlabeled…

In this paper, we present a generalized estimating equations based estimation approach and a variable selection procedure for single-index models when the observed data are clustered. Unlike the case of independent observations,…

Rapid advancements in genome sequencing have led to the collection of vast amounts of genomics data. Researchers may be interested in using machine learning models on such data to predict the pathogenicity or clinical significance of a…

We present a novel classification-based algorithm called GeneClass for learning to predict gene regulatory response. Our approach is motivated by the hypothesis that in simple organisms such as Saccharomyces cerevisiae, we can learn a…

We propose a generalized Sparse Representation- based Classification (SRC) algorithm for open set recognition where not all classes presented during testing are known during training. The SRC algorithm uses class reconstruction errors for…

Estimating the number of signals embedded in noise is a fundamental problem in array signal processing. The classic RMT estimator based on random matrix theory (RMT) tends to under-estimate the number of signals as it does not consider the…

The choice of crossover and mutation strategies plays a crucial role in the searchability, convergence efficiency and precision of genetic algorithms. In this paper, a novel improved genetic algorithm is proposed by improving the crossover…

Recovering a low-rank signal matrix from its noisy observation, commonly known as matrix denoising, is a fundamental inverse problem in statistical signal processing. Matrix denoising methods are generally based on shrinkage or thresholding…

Fair biometric algorithms have similar verification performance across different demographic groups given a single decision threshold. Unfortunately, for state-of-the-art face recognition networks, score distributions differ between…

Matrices with low-rank structure are ubiquitous in scientific computing. Choosing an appropriate rank is a key step in many computational algorithms that exploit low-rank structure. However, estimating the rank has been done largely in an…

The automatic assignment of species information to the corresponding genes in a research article is a critically important step in the gene normalization task, whereby a gene mention is normalized and linked to a database record or…

Global-local shrinkage hierarchies are an important innovation in Bayesian estimation. We propose the use of log-scale distributions as a novel basis for generating familes of prior distributions for local shrinkage hyperparameters. By…

Identifying significant subsets of the genes, gene shaving is an essential and challenging issue for biomedical research for a huge number of genes and the complex nature of biological networks,. Since positive definite kernel based methods…

Deep learning (DL) has achieved unprecedented success in a variety of tasks. However, DL systems are notoriously difficult to test and debug due to the lack of explainability of DL models and the huge test input space to cover. Generally…

Background: High-throughput techniques bring novel tools but also statistical challenges to genomic research. Identifying genes with differential expression between different species is an effective way to discover evolutionarily conserved…

The alignment of biological sequences such as DNA, RNA, and proteins, is one of the basic tools that allow to detect evolutionary patterns, as well as functional/structural characterizations between homologous sequences in different…

In high-dimensional data analysis, regularization methods pursuing sparsity and/or low rank have received a lot of attention recently. To provide a proper amount of shrinkage, it is typical to use a grid search and a model comparison…

Because of the recent advances of genome sequences, a large number of human genome sequences are available for the study of human genetics. Genome-wide association studies typically focus on associations between single-nucleotide…

Training datasets are crucial for convolutional neural network-based algorithms, which directly impact their overall performance. As such, using a well-structured dataset that has minimum level of bias is always desirable. In this paper, we…