定量生物学
Cancer is a complex genetic disease involving uncontrolled cell growth and proliferation, and necessitates effective targeting of dysregulated cellular pathways underlying cancer progression. Multiple genetic and epigenetic alterations…
Cells of diatoms and related algae with complex plastids of red algal origin are highly compartmentalized. These plastids are surrounded by four envelope membranes, which also define the periplastidic compartment (PPC), the space between…
Structural dynamics of macromolecules is critical to their structural-function relationship. Cryogenic electron microscopy (CryoEM) provides snapshots of vitrified protein at different compositional and conformational states, and the…
Partial differential equation (PDE) models for infectious diseases, while less common than their ordinary differential equation (ODE) counterparts, have found successful applications for many years. Such models are typically of…
Rationale: Transcranial magnetic stimulation (TMS)-based measures such as resting motor threshold (RMT) and short interval intracortical inhibition (SICI) are widely employed to study motor cortical and corticospinal tract function, and…
In the context of global warming, tree populations rely on two primary mechanisms of adaptation: phenotypic plasticity, which enables individuals to adjust their behavior in response to environmental stress, and genetic evolution, driven by…
While large neural nets perform impressively on specific tasks, they are unreliable and unsafe, as is shown by the persistent hallucinations of large language models. This paper shows that large neural nets are intrinsically unreliable,…
Infectious disease superspreading caused by heterogeneity in contact behavior has been observed to be an important determinant of epidemic dynamics and size in both empirical and theoretical settings. However, it has also been observed that…
The incidence of advanced renal cell carcinoma(RCC) has been rising, presenting significant challenges due to the limited efficacy and severe side effects of traditional radiotherapy and chemotherapy. While combination immunotherapies show…
Wolbachia, a maternally transmitted endosymbiont, offers a powerful biological control strategy for mosquito-borne diseases such as dengue, Zika, and malaria. We develop an integro-difference equation (IDE) model that integrates Wolbachia's…
Sleep is thought to support memory consolidation and the recovery of optimal energetic regime by reorganizing synaptic connectivity, yet how plasticity across hierarchical brain circuits contributes to abstraction and energy efficiency…
We suggest a new approach to $\beta$-diversity in ecological systems, based on the energy of the graph sheaf Laplacian associated with the sample data. This scalar quantity is easily computable using methods of linear algebra. We show using…
Motivation: High-throughput sequencing (HTS) enables population-scale genomics but generates massive datasets, creating bottlenecks in storage, transfer, and analysis. FASTQ, the standard format for over two decades, stores one byte per…
The accurate prediction of protein-ligand binding affinity is important for drug discovery yet remains challenging for multi-domain proteins, where inter-domain dynamics and flexible linkers govern molecular recognition. Current geometric…
Long-term evolutionary processes can strongly influence common-pool resource conservation by generating new traits or behaviours that modify the feedback between population strategies and the resource state. Here we develop an…
Tree balance has received considerable attention in recent years, both in phylogenetics and in other areas. Numerous (im)balance indices have been proposed to quantify the (im)balance of rooted trees. A recent comprehensive survey…
Understanding interactions in complex systems requires capturing the relative timing of coupling, not only its strength. Phase synchronization captures this timing, yet most methods either reduce the phase to its cosine or collapse it into…
Understanding how prenatal exposure to psychoactive substances such as cannabis shapes adolescent brain organization remains a critical challenge, complicated by the complexity of multimodal neuroimaging data and the limitations of…
Perfusion imaging is extensively utilized to assess hemodynamic status and tissue perfusion in various organs. Computed tomography perfusion (CTP) imaging plays a key role in the early assessment and planning of stroke treatment. While CTP…
Understanding how microenvironmental heterogeneity influences tumor progression is essential for advancing both cancer biology and therapeutic strategies. In this study, we develop a cellular automata (CA) model to simulate tumor growth…