组织与器官
Background: Radiotherapy outcomes are usually predicted using the Linear Quadratic model. However, this model does not integrate complex features of tumor growth, in particular cell cycle regulation. Methods: In this paper, we propose a…
The biochemical changes on normal and degenerated tissues of rotator cuff supraspinatus tendons were probed by FT-Raman spectroscopy. The Raman spectra showed differences on the spectral regions of cysteine, amino acids, nucleic acids,…
The differential Adhesion Hypothesis (DAH) is a theory of the organization of cells within a tissue. In this study we introduce a stochastic model supporting the DAH, that can be seen as a continuous version of a discrete model of Graner…
We model the interaction between the immune system and tumor cells including a time delay to simulate the time needed by the latter to develop a chemical and cell mediated response to the presence of the tumor. The results are compared with…
In its broadest definition, systems biology is the application of a `systems' way of thinking about and doing cell biology. By implication, this also invites us to consider a systems approach in the context of medicine and the treatment of…
Experiments that discuss influence of noise to H. Seidel and H. Herzel dynamics model of human cardiovascular system are presented. Noise is introduced by considering stochastic delays in response to the sympathetic system. It appears that…
Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated activation of the signaling protein phospholipase C gamma plays a critical role in a cancer cell's phenotypic decision to either proliferate or to migrate…
We argue that volumetric growth dynamics of a solid cancer depend on the tumor system's overall surface extension. While this at first may seem evident, to our knowledge, so far no theoretical argument has been presented explaining this…
A complete parametric analysis of dynamic regimes of a conceptual model of anti-tumor virus therapy is presented. The role and limitations of mass-action kinetics are discussed. A functional response, which is a function of the ratio of…
A model is proposed to minimize the total volume of the main distribution networks of fluids in organs such as the kidney and the lung. A consequence of the minimization analysis is that the optimal overall form of the organs is a modified…
Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular…
We investigate a mechanism for the robust identification of the center of a developing biological system. We assume the existence of two morphogen gradients, an activator emanating from the anterior, and a co-repressor from the posterior.…
In comparative and developmental neuroanatomy one encounters questions regarding the deformation of neural tissue under stress. The motivation of this note is an observation (Barbas {\it et al}) that at cortical folds or gyri, the layers of…
A theoretical model based on the molecular interactions between a growing tumor and a dynamically evolving blood vessel network describes the transformation of the regular vasculature in normal tissues into a highly inhomogeneous tumor…
This article describes the application of recently introduced complex networks concepts and methods to the characterization and analysis of cortical bone structure. Three-dimensional reconstructions of the system of channels underlying bone…
Colour parameters of European beech were measured using CIELab system. 103 logs from 87 trees in 9 sites were cut into boards to study the variations of wood colour parameters. Both site and tree effect on colour were observed. Patterns of…
We make comments on the paper by Miller [{\it J. Theor. Biol.} {\bf 234} (2005) 511].
Eyespots are concentric motifs with contrasting colours on butterfly wings. Eyespots have intra- and inter-specific visual signalling functions with adaptive and selective roles. We propose a reaction-diffusion model that accounts for…
We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of…
Most human carcinomas exhibit telomere abnormalities early in the carcinogenesis process suggesting that crisis caused by telomere shortening may be a necessary event leading to human carcinomas. Epidemiological records of the age at which…