定量方法
Genetic nurture effects and assortative mating (AM) occur across many human behaviors and can bias estimates from traditional genetic models. These influences are typically studied univariately, within the same trait. However, estimation of…
Photoplethysmography (PPG) is a common tool for monitoring cardiopulmonary health. Relying on absorption or reflectance of light by hemoglobin in the blood, the measured PPG waveform can be analyzed per heart beat using physiological…
Medical imaging has revolutionized diagnosis, yet unnecessary procedures are rising, exposing patients to radiation and stress, limiting equitable access, and straining healthcare systems. The American College of Radiology Appropriateness…
Arterial aneurysm (Fig.1) is a bulb-shape local expansion of human arteries, the rupture of which is a leading cause of morbidity and mortality in US. Therefore, the prediction of arterial aneurysm rupture is of great significance for…
Viral infections trigger complex immune responses with heterogeneous outcomes shaped by nonlinear feedbacks. An ordinary differential equation model is developed to investigate immune response dynamics during viral infection, incorporating…
High-resolution imaging provides dense trajectories of migrating cells, flocking animals, and synthetic active particles, from which interaction laws can be determined with a wide variety of methods. Yet, distinguishing whether front-back…
Protein-ligand binding is the process by which a small molecule (drug or inhibitor) attaches to a target protein. Binding affinity, which characterizes the strength of biomolecular interactions, is essential for tackling diverse challenges…
Colorectal cancer (CRC) is highly heterogeneous, with five-year survival rates dropping from $\sim$90% in localized disease to $\sim$15% with distant metastases. Disease progression is shaped not only by tumor-intrinsic alterations but also…
The selection of appropriate medical imaging procedures is a critical and complex clinical decision, guided by extensive evidence-based standards such as the ACR Appropriateness Criteria (ACR-AC). However, the underutilization of these…
Correlated motions of proteins underpin many physiological mechanisms, such as substrate binding, signal transduction, enzymatic activity and allostery. These motions arise from low frequency collective movements of biomolecules and have…
Hidden Markov models (HMMs) have been used increasingly to understand how movement patterns of animals arise from behavioural states. An animal is assumed to transition between behavioural states through time, as described by transition…
Low vision involves a range of visual impairments that significantly impact daily activities, particularly navigation in urban environments. Individuals with low vision often develop adaptive strategies to compensate for visual deficits,…
Objective: To develop an explainable multimodal large language model (MM-LLM) that (1) screens optic nerve head (ONH) OCT circle scans for quality and (2) generates structured clinical reports that include glaucoma diagnosis and sector-wise…
Predicting the future evolutionary trajectory of SARS-CoV-2 remains a critical challenge, particularly due to the pivotal role of spike protein mutations. It is therefore essential to develop evolutionary models capable of continuously…
Background: The existence of different basal cell carcinoma (BCC) clinical criteria cannot be objectively validated. An adequate ground-truth is needed to train an artificial intelligence (AI) tool that explains the BCC diagnosis by…
Bioinformatics tools are essential for complex computational biology tasks, yet their integration with emerging AI-agent frameworks is hindered by incompatible interfaces, heterogeneous input-output formats, and inconsistent parameter…
Automated semantic segmentation of whole-slide images (WSIs) stained with hematoxylin and eosin (H&E) is essential for large-scale artificial intelligence-based biomarker analysis in breast cancer. However, existing public datasets for…
Effective recognition of foreign antigens by the adaptive immune system relies on T cells being activated by antigen-presenting cells (APCs) in lymph nodes. Here, diffusing T cells may encounter cognate APCs that present matching antigen…
The integration of artificial intelligence (AI) in early-stage drug discovery offers unprecedented opportunities for exploring chemical space and accelerating hit-to-lead optimization. However, docking optimization in generative approaches…
Recent advances in large language models (LLMs) and biomedical foundation models (BioFMs) have achieved strong results in biological text reasoning, molecular modeling, and single-cell analysis, yet they remain siloed in disjoint embedding…